DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and ADCY8

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001106.1	Gene:	ADCY8 / 114	HGNCID:	239	Length:	1251	Species:	Homo sapiens

Alignment Length:	605	Identity:	117/605 - (19%)
Similarity:	195/605 - (32%)	Gaps:	207/605 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SGPHPLPVEVTAAEEEQAATFG-QTSPQKL---SLKGSQLGGSI---------------LIGNYN 68
            ||...||:......|...:|.| :..|::.   |..||..||.:               |.|.|:
Human    84 SGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYS 148

  Fly    69 YLTQL-EVCENEMEVLDLSSLAQLETLKCSRNKLMELIING----TNLQTLVADHNYLHNISTTN 128
            |...: ....|..:..||..|.|...|  .:.:..|:::|.    |.|..||     || :|..:
Human   149 YRGVIFPTLRNSFKSRDLERLYQRYFL--GQRRKSEVVMNVLDVLTKLTLLV-----LH-LSLAS 205

  Fly   129 THPVPLK-------------------LQRIDISHN--NFSELPNWVGACASLTAINASHNRLNNV 172
            ....|||                   :::...||.  .:|.:..||.....:.|....:..|.:.
Human   206 APMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDG 270

  Fly   173 A--VLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSI---------RSLQLQSNELPSLPDNFFA 226
            .  ||...:....::.|.|.:..|..|     |.|.:         |...:..|::.:....|..
Human   271 IGYVLFTLFATYSMLPLPLTWAILAGL-----GTSLLQVILQVVIPRLAVISINQVVAQAVLFMC 330

  Fly   227 VTHA---------------------------RLETLNVSCNK--LSTLPRYEQNNHAALVNLSLA 262
            :..|                           ||||.|....:  ||.|||:        |.|.:.
Human   331 MNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRF--------VVLEMI 387

  Fly   263 GNHLN---DSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATL 324
            .:..|   :.:....|     |:....|..:.:| .|.|:.:..|...:.:..:::.|.|..|..
Human   388 NDMTNVEDEHLQHQFH-----RIYIHRYENVSIL-FADVKGFTNLSTTLSAQELVRMLNELFARF 446

  Fly   325 GQL---------RVLRCCNNLLLCTPQLAKLAMLKVLDLSHNH------LDRVNLLALVPSRNLK 374
            .:|         ::|..|...:...|:..:         .|.|      |..:..:..|.||...
Human   447 DRLAHEHHCLRIKILGDCYYCVSGLPEPRQ---------DHAHCCVEMGLSMIKTIRYVRSRTKH 502

  Fly   375 YLDL-----SGNL---QLQVDEQQFKVCQSQSQRHWSL-VDVSGNNRAALPTTKIRQVSAQRNQN 430
            .:|:     ||::   .|.:.:.||.|        ||. ||::                   |:.
Human   503 DVDMRIGIHSGSVLCGVLGLRKWQFDV--------WSWDVDIA-------------------NKL 540

  Fly   431 KTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEM--SHLVPD- 492
            ::.|        .||.....|.::            :.|.|.:...||.|:...|.  .|.:..
Human   541 ESGG--------IPGRIHISKATL------------DCLNGDYNVEEGHGKERNEFLRKHNIETY 585

  Fly   493 LMKQ---------EQMVKDS 503
            |:||         |.:||:|
Human   586 LIKQPEDSLLSLPEDIVKES 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/22 (14%)
		LRR_8	109..169	CDD:290566	16/80 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	5/23 (22%)
		leucine-rich repeat	159..183	CDD:275380	4/25 (16%)
		leucine-rich repeat	184..209	CDD:275380	6/33 (18%)
		LRR_8	205..266	CDD:290566	17/98 (17%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	9/24 (38%)
		LRR_RI	<256..410	CDD:238064	34/180 (19%)
		leucine-rich repeat	256..276	CDD:275380	3/22 (14%)
		LRR_8	279..359	CDD:290566	15/94 (16%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	8/52 (15%)
		leucine-rich repeat	349..372	CDD:275380	5/28 (18%)
		PP2Cc	461..655	CDD:294085	14/55 (25%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..182		23/99 (23%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..109		7/24 (29%)
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..92		4/7 (57%)
		AC_N	<161..400	CDD:292831	49/259 (19%)
		CYCc	366..564	CDD:214485	47/267 (18%)
		Guanylate_cyc	405..589	CDD:278633	42/240 (18%)
		DUF1053	617..711	CDD:283888
		CYCc	944..1148	CDD:214485
		Guanylate_cyc	973..1172	CDD:278633
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1109..1251
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1200..1215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900