DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and Gucy2e

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_570093.2 Gene:Gucy2e / 113911 RGDID:69322 Length:1123 Species:Rattus norvegicus


Alignment Length:687 Identity:130/687 - (18%)
Similarity:205/687 - (29%) Gaps:231/687 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 NHAALVNLSLAGNHLNDSI-----------------------------------FEPLH----NA 277
            ||:......|:|.||.:.|                                   ..|.|    :.
  Rat   374 NHSEAHGTGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLPQYVILDTNGEGSQLVPTHILDVST 438

  Fly   278 AKLRVLHLAYNRIGVLPAA------------CVRNWPELE---------ILVLSGNMLQQLPEEV 321
            .:::.|..|.:..|..|.|            |:|....|.         :|.|.|..|...    
  Rat   439 QQVQPLGTAVHFPGGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYF---- 499

  Fly   322 ATLG--QLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQL 384
            ..||  |||:||..:.:|| |||                  .:..|...|||...::| ||    
  Rat   500 IRLGLQQLRLLRGPHRILL-TPQ------------------ELTFLQRTPSRRRPHVD-SG---- 540

  Fly   385 QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSA---QRNQNKTSGPWT-MGFAETPG 445
                       |:|:   |:||  |.:..::.....|.|.|   ..|.....|.|. :...|...
  Rat   541 -----------SESR---SVVD--GGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGT 589

  Fly   446 SGDCRKLSVYQLRAANYGGSDE--ALYGMFEALEGRGRAAQEMSHL----VPDLMKQEQMVKDSA 504
            :.|.|..|:..||.......:.  |..|:|   .|...:|..:.|.    :.||::.|.:..|..
  Rat   590 APDLRPSSLSLLRKMREMRHENVTAFLGLF---VGPEVSAMVLEHCARGSLEDLLRNEDLRLDWT 651

  Fly   505 VRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSK------RYVLRMASTGGLDAYLI 563
            .:..:...|:.      .:|.....|....|       |||:      |:||::...|  .|..:
  Rat   652 FKASLLLDLIR------GLRYLHHRHFPHGR-------LKSRNCVVDTRFVLKITDHG--YAEFL 701

  Fly   564 RRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS 628
            ......|               |.|...||               ||:..::.|..|.......:
  Rat   702 ESHCSFR---------------PQPAPEEL---------------LWTAPELLRGPRRPWGPGKA 736

  Fly   629 LLAAKRLVDIAQSFAAAESLSVIVVR---FRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVC 690
            ....    |:   |:....|..::.|   :...|...:.:||::     ..|.|:..||.|....
  Rat   737 TFKG----DV---FSLGIILQEVLTRDPPYCSWGLSAEEIIRKV-----ASPPPLCRPLVSPDQG 789

  Fly   691 KRTCCDRSNACRHRAIEQEPL------------AGRSSPSGQSDRDLLAK----------DKDDE 733
            ...|......|...|.:..|.            .|:.:....|...:|.|          ::.:|
  Rat   790 PLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEE 854

  Fly   734 FVL-----------------AHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLE-----Q 776
            ..|                 |||..:....:.|..|:.......::...........:|     .
  Rat   855 LELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLN 919

  Fly   777 NTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERN 813
            :...:||..|:  |....|..|:.:|.|.|:.||.||
  Rat   920 DLYTMFDAVLD--SHDVYKVETIGDAYMVASGLPRRN 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566 4/13 (31%)
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380 2/2 (100%)
LRR_RI <256..410 CDD:238064 43/215 (20%)
leucine-rich repeat 256..276 CDD:275380 7/58 (12%)
LRR_8 279..359 CDD:290566 24/102 (24%)
leucine-rich repeat 280..303 CDD:275380 7/34 (21%)
leucine-rich repeat 304..348 CDD:275380 17/54 (31%)
leucine-rich repeat 349..372 CDD:275380 3/22 (14%)
PP2Cc 461..655 CDD:294085 35/208 (17%)
Gucy2eNP_570093.2 PBP1_sensory_GC_DEF-like 71..445 CDD:380594 9/70 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..556 12/47 (26%)
PK_GC-2D 554..824 CDD:270945 59/329 (18%)
CYCc 861..1050 CDD:214485 19/96 (20%)
Interaction with NCALD. /evidence=ECO:0000269|PubMed:18178149 880..921 3/40 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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