DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AgaP_AGAP012965

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_003436066.1	Gene:	AgaP_AGAP012965 / 11175716	VectorBaseID:	AGAP012965	Length:	555	Species:	Anopheles gambiae

Alignment Length:	215	Identity:	47/215 - (21%)
Similarity:	80/215 - (37%)	Gaps:	59/215 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LSSLAQLETL--KCSRNKLMELII-----------------NGTNLQTLVADHNYLHNIS-TTNT 129
            ||::.:...|  .|.|.|..|..|                 |.|....|..|.|...::: .:|.
Mosquito    37 LSAIYRKSVLFWPCPRMKATEKFIPSYETVSFAVKSIAQQLNWTEAVLLATDANRALSLALASNL 101

  Fly   130 H-PVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVL--LRNYRITELVSLDLA- 190
            | |..:.:....|. ::|::      :...:..|.:|.|....::|:  |:.|..|:::.|||.
Mosquito   102 HIPYTIAMDATSIP-SSFND------SNGKVVIICSSINSPQTISVINQLKQYSRTKILLLDLVG 159

  Fly   191 ---------YNDLKQ--LDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETL------NVS 238
                     |..|.:  .:.|.|.....|:|.:    |..|.:.|.:..| ||..:      ::|
Mosquito   160 TIFNSNNVLYRRLAENGAEPFGEALRHRRNLLV----LTILTEKFRSFLH-RLHGVDLGDYKHIS 219

  Fly   239 CNKL------STLPRYEQNN 252
            .|.|      ..|||...|:
Mosquito   220 ENLLKIRLMDDKLPRDTGND 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/37 (19%)
		LRR_8	109..169	CDD:290566	12/61 (20%)
		leucine-rich repeat	111..135	CDD:275380	6/25 (24%)
		leucine-rich repeat	136..158	CDD:275380	2/21 (10%)
		leucine-rich repeat	159..183	CDD:275380	6/25 (24%)
		leucine-rich repeat	184..209	CDD:275380	7/36 (19%)
		LRR_8	205..266	CDD:290566	15/60 (25%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	8/33 (24%)
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
AgaP_AGAP012965	XP_003436066.1	ANF_receptor	12..>175	CDD:279440	30/144 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900