DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and lrriq4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_031758114.1	Gene:	lrriq4 / 108644471	XenbaseID:	XB-GENE-948455	Length:	596	Species:	Xenopus tropicalis

Alignment Length:	402	Identity:	106/402 - (26%)
Similarity:	170/402 - (42%)	Gaps:	90/402 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QKLSLKGSQLGGSIL--IGNYNYLTQLEVCENEMEVLDL---SSLAQLETLKCSRNKLMEL---I 105
            |:|.|..:.|....|  :....:|.:|.:....:|.|.:   :||..||.|..|.|.||.|   .
Frog   133 QRLDLSFNPLEYDSLNIVSKVQHLRELRLYSANLEELPVAICNSLQCLELLGLSNNHLMSLPEET 197

  Fly   106 INGTNLQTLVADHNYLHNI-----------------STTNTHPVPL----KLQRIDISHNNFSEL 149
            :....|:.:...:|.|.|.                 :.....|..:    ||.::.:..|:.|.:
Frog   198 VKLVQLKEIYLQNNKLENFPMELCLLPNLEIIDLERNALKAIPAEIGSLSKLLKLFLGFNSISVI 262

  Fly   150 PNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPE---GFSSIRSLQ 211
            |..:..|..|:|::||:|.|.|:...||  ::|||..|.|:.|   :|.:||.   ..||:..|.
Frog   263 PKSLSRCTKLSALDASNNCLQNIIPHLR--KLTELNELALSGN---ELGEFPSKLCKLSSLSVLY 322

  Fly   212 LQSNELPSLPDNFFAVTHARLETLNVSCNKLS-------TLPRYE----QNNHAALV-------- 257
            |::..:..||.:...:::.|:  |::|.|.|:       ||.:.|    .:||.:|:
Frog   323 LKNTAIKMLPSDLSNLSYIRV--LDLSQNLLTEIPPVICTLKQLEILSLDDNHISLIIPEIKELT 385

  Fly   258 ---NLSLAGNHLND-----SIFEPLHNA-----AKLRVLHLAYNRIGVLPAACVRNWPELEILVL 309
               .|.|.||....     .:.|.|...     ...|:.||:.|      ...::|..||.|
Frog   386 QLNYLGLTGNRFTGFPEEICLLESLERLYIGQDQGTRLAHLSEN------ICMLKNLKELYI--- 441

  Fly   310 SGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHL----DRVNLLALVP 369
            ..|.|:.||..::.|..|.:|.|.||||...|: :..|..|:.|.|.:|.|    |:::||.
Frog   442 ENNNLECLPSNISCLQNLIILDCRNNLLKQLPEGICSLQALQKLLLQNNRLSVLPDKLDLLP--- 503

  Fly   370 SRNLKYLDLSGN 381
              .|:.|.|.||
Frog   504 --KLELLALEGN 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/21 (38%)
		LRR_8	109..169	CDD:290566	16/80 (20%)
		leucine-rich repeat	111..135	CDD:275380	5/44 (11%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	9/23 (39%)
		leucine-rich repeat	184..209	CDD:275380	9/27 (33%)
		LRR_8	205..266	CDD:290566	21/82 (26%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	9/33 (27%)
		LRR_RI	<256..410	CDD:238064	42/152 (28%)
		leucine-rich repeat	256..276	CDD:275380	7/35 (20%)
		LRR_8	279..359	CDD:290566	26/80 (33%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	16/44 (36%)
		leucine-rich repeat	349..372	CDD:275380	8/26 (31%)
		PP2Cc	461..655	CDD:294085
lrriq4	XP_031758114.1	PLN00113	76..>469	CDD:215061	89/351 (25%)
		leucine-rich repeat	86..108	CDD:275380
		leucine-rich repeat	109..131	CDD:275380
		leucine-rich repeat	132..155	CDD:275380	5/21 (24%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..225	CDD:275380	12/44 (27%)
		leucine-rich repeat	226..271	CDD:275380	7/44 (16%)
		leucine-rich repeat	272..294	CDD:275380	9/23 (39%)
		leucine-rich repeat	295..317	CDD:275380	7/24 (29%)
		leucine-rich repeat	318..340	CDD:275380	4/21 (19%)
		leucine-rich repeat	364..386	CDD:275380	4/21 (19%)
		leucine-rich repeat	387..409	CDD:275380	4/21 (19%)
		leucine-rich repeat	410..435	CDD:275380	5/30 (17%)
		leucine-rich repeat	436..458	CDD:275380	8/24 (33%)
		leucine-rich repeat	459..481	CDD:275380	9/21 (43%)
		IQ	539..558	CDD:197470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910