DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Adcy4

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001348533.1 Gene:Adcy4 / 104110 MGIID:99674 Length:1077 Species:Mus musculus


Alignment Length:345 Identity:74/345 - (21%)
Similarity:105/345 - (30%) Gaps:133/345 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   560 AYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRK 624
            ||.:.|.             |..|.  ||::.||   .:..|||           ||..|    :
Mouse   421 AYAVERA-------------DTEHR--DPYLREL---GEPTYLV-----------IDPRA----E 452

  Fly   625 EENSLLAAKRLVDIAQSFAAAESLSVIVVR----------FRHLGTDVDHLIRELKQSVRKKPQP 679
            ||:....||.|:...:......||  ::.|          |.||    .||         ..|..
Mouse   453 EEDEKGTAKGLLSSLEGHTMRPSL--LMTRYLESWGAAKPFAHL----SHL---------DSPVS 502

  Fly   680 VSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQE 744
            .|.||...:.                          ||....||....:..|||.....|:..|.
Mouse   503 TSTPLPEKAF--------------------------SPQWSLDRSRTPRGLDDELDTGDAKFFQV 541

  Fly   745 EQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQ---RTVP--NAIM 804
            .:||.             |::|   |:...:.|...|:.:|     |...||   ..:|  ....
Mouse   542 IEQLN-------------SQKQ---WKQSKDFNLLTLYFRE-----KEMEKQYRLSALPAFKYYA 585

  Fly   805 AATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPL----------GSYHQVKQAPPG-- 857
            |.|.|...::||..::       ::|..|.|  .||.|:..          .|.|..|....|  
Mouse   586 ACTFLVFLSNFTIQML-------VTTRPPAL--IITYSITFLLFFLLLFVCFSEHLTKCVQKGPK 641

  Fly   858 --HFGSALSFQQAHSYGYNL 875
              |:..|||...|...|:.:
Mouse   642 MLHWLPALSVLVATRPGFRV 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380
LRR_RI <256..410 CDD:238064
leucine-rich repeat 256..276 CDD:275380
LRR_8 279..359 CDD:290566
leucine-rich repeat 280..303 CDD:275380
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085 23/104 (22%)
Adcy4NP_001348533.1 AC_N <115..246 CDD:318454
Guanylate_cyc 264..418 CDD:306677
DUF1053 479..580 CDD:368844 30/160 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..524 7/47 (15%)
Guanylate_cyc 866..1065 CDD:306677
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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