DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and podn

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_031756818.1	Gene:	podn / 101730272	XenbaseID:	XB-GENE-963382	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	113/446 - (25%)
Similarity:	187/446 - (41%)	Gaps:	119/446 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YKSKLKVSASHSGPHPLPVEVTAAE-------EEQAATFGQTSPQKLSLKGSQLGGSILIGNYNY 69
            |.:..|:|.:   |..||..:.:|:       :....|||    .|.:|:...|       :.|.
Frog   144 YLANNKLSLA---PRFLPSSLISADFAANNITKIYEMTFG----HKPNLRSVYL-------HDNK 194

  Fly    70 LTQLEVCE------NEMEVLDLSS-------------LAQLETLKCSRNKLMELIING-----TN 110
            ||...:.:      |.:|.|.|||             |.:|..    :|..:|.|.:|     |:
Frog   195 LTDAGIPDNMFNRSNRVETLILSSNFLKYVPKNLPPALCKLHL----QNNKLESIPSGAFSHLTD 255

  Fly   111 LQTLVADHNYLHNISTTNTHPVPL-KLQRIDISHNNFSELPNWVGACASLTAINASHNRL----N 170
            |:.|...:|.|.|....|.....| ||:.:|:|.||.:::|:  |...::..::...|.:    :
Frog   256 LRELYLLNNRLSNEGMDNETFTKLNKLEYLDLSSNNLTKIPS--GLPRNIVILHLEKNSIRFISD 318

  Fly   171 NVAVLLRNYRITELVSLDL--------------------AYNDLKQLDQFPEGF-SSIRSLQLQS 214
            ||...:||.....|.:..|                    .||:|  |::.|.|. ..:::|.|..
Frog   319 NVLTQIRNLEYLLLHNNKLRAHGIHPGAFVGLKKLHTVHVYNNL--LEKVPPGLPRRVKTLMLLH 381

  Fly   215 NELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAK 279
            |::.|:..|.||.|:. ||.||:|.||:                  ::|| ::...|..|.   .
Frog   382 NQISSISKNDFATTYL-LEDLNLSYNKI------------------MSGN-VHKEAFRKLR---L 423

  Fly   280 LRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVAT-LGQLRVLRCCNNLL----LC 339
            |:.|.|:.|.:..:|....:|   ||||.|..|.:..:|::..| :.:|:.....||.|    ..
Frog   424 LKTLELSGNNLKSVPYGLPKN---LEILRLKDNDISSIPQDSLTGMIKLKEFYLSNNKLKLSSFY 485

  Fly   340 TPQLAKLAMLKVLDLSHNHLDRVNLLALVPS---RNLKYLDLSGNLQLQVDEQQFK 392
            :...|:|:.|::||||.|.      |:.:||   ..|:||.|..|..:.||:..|:
Frog   486 SGAWAELSSLQILDLSGNQ------LSYIPSDLPETLEYLYLQSNKIITVDDSAFE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/23 (22%)
		LRR_8	109..169	CDD:290566	17/60 (28%)
		leucine-rich repeat	111..135	CDD:275380	7/24 (29%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/27 (19%)
		leucine-rich repeat	184..209	CDD:275380	8/45 (18%)
		LRR_8	205..266	CDD:290566	17/60 (28%)
		leucine-rich repeat	210..230	CDD:275380	8/19 (42%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	41/145 (28%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	26/84 (31%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	14/48 (29%)
		leucine-rich repeat	349..372	CDD:275380	9/25 (36%)
		PP2Cc	461..655	CDD:294085
podn	XP_031756818.1	LRRNT	59..87	CDD:396168
		leucine-rich repeat	90..113	CDD:275380
		PLN00113	105..>512	CDD:215061	105/421 (25%)
		leucine-rich repeat	114..139	CDD:275380
		leucine-rich repeat	140..184	CDD:275380	11/46 (24%)
		leucine-rich repeat	185..210	CDD:275380	5/31 (16%)
		leucine-rich repeat	211..231	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	6/26 (23%)
		leucine-rich repeat	256..281	CDD:275380	7/24 (29%)
		leucine-rich repeat	282..302	CDD:275380	7/21 (33%)
		leucine-rich repeat	303..326	CDD:275380	3/22 (14%)
		leucine-rich repeat	327..352	CDD:275380	2/24 (8%)
		leucine-rich repeat	353..373	CDD:275380	6/21 (29%)
		leucine-rich repeat	374..397	CDD:275380	8/22 (36%)
		leucine-rich repeat	398..423	CDD:275380	11/46 (24%)
		leucine-rich repeat	424..445	CDD:275380	6/23 (26%)
		leucine-rich repeat	446..468	CDD:275380	7/21 (33%)
		leucine-rich repeat	469..494	CDD:275380	6/24 (25%)
		leucine-rich repeat	495..515	CDD:275380	9/25 (36%)
		LRR_8	515..575	CDD:404697	8/21 (38%)
		leucine-rich repeat	516..539	CDD:275380	8/20 (40%)
		leucine-rich repeat	540..565	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910