DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Chadl

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_038936217.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	747	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	99/360 - (27%)
Similarity:	140/360 - (38%)	Gaps:	87/360 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QTLVADHNYLH------NISTTNTHPVPLKLQRIDISHN--------NFSELPNWVGACASLTAI 162
            ||.|.|::..|      |: |.....:|...||:|:..|        .|.:||       .||.:
  Rat    39 QTCVCDNSRRHVTCQHQNL-TEVPDTIPELTQRLDLQGNMLKVIPPAAFQDLP-------YLTHL 95

  Fly   163 NASHNRLNNVAV-LLRNYRITELVSLDLAYNDLKQLDQFP-EGFSSIRSLQLQSNELPSL-PDNF 224
            :..|.::..||. ..|.  :..|:.|:||.|.|..|.|.. :|..|:|.|:|:.|.|..| |..|
  Rat    96 DLQHCQVEQVAEGAFRG--LGRLLFLNLASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGTF 158

  Fly   225 FAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNR 289
            .|:  ..|.|||::.|.|..||             ::|        |:.|   .:.|.|.|::|.
  Rat   159 GAL--GSLATLNLAHNALVYLP-------------AMA--------FQGL---MRTRWLQLSHNA 197

  Fly   290 IGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRV---LRCCNNLLLCTPQLAKLAM--L 349
            :.||....:...|.|..|.|..|.||.||.  |.|.|.|.   |...:|.|..|.:...||:  |
  Rat   198 LSVLAPEALAGLPVLRRLSLHHNELQALPG--AALSQARSLARLELGHNPLTYTGEEDGLALPGL 260

  Fly   350 KVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNL-----QLQVDEQQFKV----------CQSQSQ 399
            :.|.|.|..|..:...|......|..|||.||.     .|||..|..::          |.::..
  Rat   261 RELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLPPLQVPGQLRRLRLQGNPLWCACHARPL 325

  Fly   400 RHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSG 434
            ..|            |...::|...|.|...:..|
  Rat   326 LEW------------LVRARVRSDGACRGPRRLRG 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	18/70 (26%)
		leucine-rich repeat	111..135	CDD:275380	8/28 (29%)
		leucine-rich repeat	136..158	CDD:275380	7/29 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	10/25 (40%)
		LRR_8	205..266	CDD:290566	19/61 (31%)
		leucine-rich repeat	210..230	CDD:275380	8/20 (40%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		LRR_RI	<256..410	CDD:238064	46/173 (27%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	29/84 (35%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	17/46 (37%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085
Chadl	XP_038936217.1	PLN00113	30..>555	CDD:215061	99/360 (28%)
		leucine-rich repeat	48..66	CDD:275380	3/18 (17%)
		leucine-rich repeat	68..91	CDD:275380	7/29 (24%)
		leucine-rich repeat	92..115	CDD:275380	6/24 (25%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		leucine-rich repeat	140..163	CDD:275380	9/24 (38%)
		leucine-rich repeat	164..187	CDD:275380	11/46 (24%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		leucine-rich repeat	212..235	CDD:275380	11/24 (46%)
		leucine-rich repeat	236..259	CDD:275380	6/22 (27%)
		leucine-rich repeat	260..283	CDD:275380	6/22 (27%)
		leucine-rich repeat	306..345	CDD:275380	6/50 (12%)
		leucine-rich repeat	425..448	CDD:275380
		PPP1R42	446..603	CDD:411060
		leucine-rich repeat	449..472	CDD:275380
		leucine-rich repeat	473..496	CDD:275380
		leucine-rich repeat	497..520	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..568	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		LRR_8	591..653	CDD:404697
		leucine-rich repeat	593..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	643..665	CDD:275380
		leucine-rich repeat	666..677	CDD:275378
		LRRCT	673..721	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000