DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and tril

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002933436.2	Gene:	tril / 100498304	XenbaseID:	XB-GENE-6050227	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	640	Identity:	151/640 - (23%)
Similarity:	245/640 - (38%)	Gaps:	164/640 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 CENEMEVLDLSSLAQLETLKCSRNKLMEL-----IINGTNLQTLVADHNYLHNISTTNTHPVPLK 135
            |:::..||            ||...|:.:     :::.:..:|.....|::.|||..:....| :
Frog    31 CQHQQHVL------------CSNRGLLSVPKSSHMLSSSATKTFSLGGNFIANISALDFVQFP-Q 82

  Fly   136 LQRIDISHNNFSEL-------------------------PNWVGACASLTAINASHNRLNNVA-V 174
            |||:|:.:|....:                         |..:.....|..:|.:.|||:|:: |
Frog    83 LQRLDLQYNRIGSIHPKAFEKLTELEELYLGNNLLATLAPGALAPLRKLKVLNVNGNRLHNISRV 147

  Fly   175 LLRNYRITELVSLDLAYNDLKQLDQFP-EGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVS 238
            ...|  :..|:.|.|..||::.|...| ...|::..|.|::|::.::..|.|... .:|..|::|
Frog   148 SFSN--LAALIKLRLDGNDIQNLQGSPFSALSNLLYLHLENNKITNISKNAFTGL-GKLRLLSLS 209

  Fly   239 CNKLSTLPRYEQNNHAALVNLSLAGNHLND---SIFEPLHNAAKLRVLHLAYNRIGVLPAACVRN 300
            .|..|.|.:.......||..|::|||.|..   |:|..|.   :|..|.|:.|:|.|:.......
Frog   210 GNPQSFLRQPTFLPLRALSTLTMAGNQLQQLGPSLFNGLQ---RLSRLVLSSNQISVIQTKTFLG 271

  Fly   301 WPELEILVLSGNMLQQLPEEV-ATLGQLRVLRCCNNLLL-CTPQLAK-LAMLKVLDLSHNHLDRV 362
            ...|:.|.|.||.|.||||.| ..|..|.||....|.:. ..|:..| |..|:||||.||.|
Frog   272 LDLLQELHLDGNKLVQLPEGVLVPLHNLEVLNLSRNAISHLHPETFKGLMRLRVLDLQHNML--- 333

  Fly   363 NLLALVPSRNLKYLDLSGN---LQLQVDEQQFKV-CQSQSQRHWSLVDVSGNNRAALPTTKIRQV 423
                    |.|.....:||   .:||:|..::.. ||....:||.|..:  ::|:.:.|..::..
Frog   334 --------RYLSGQTFAGNPVLYRLQLDGNRWSCDCQLLDLKHWILGTL--HSRSRMLTVFVQCF 388

  Fly   424 SAQRNQNK------TSGPWTMG---FAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGR 479
            ..|:...|      .|..|.:|   .:.||...:  ::....|...|. |..:|..|..:.:...
Frog   389 EPQKVAGKYLDYLEDSYLWDVGGCRISTTPAGQE--QMMTSTLSDGNI-GVHQARKGDIDLIVVT 450

  Fly   480 GR-------AAQEMSHLVPD------------LMKQEQMV--------KDSAVRDYMKFTLLAAQ 517
            |.       ..:|.|..:|.            .::|:.:|        ||...::.   .|..::
Frog   451 GADNLRVQPKTEEKSLQLPTPPSEVSPALETLALRQQALVTKWPSSTNKDGTAKNR---GLETSR 512

  Fly   518 QQCG-SVRSAA----LFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQL-------- 569
            :..| ||:::|    ..||    ....|.|.:||   ::..|.      ||..:|.|
Frog   513 KGKGKSVKNSAEHSRKLHL----VAQPVHPTQSK---VKQVSV------LIPASSNLPPNSESMH 564

  Fly   570 -----RLTKPDVI-------------QKDQIHSMP----DPHVLELILSNDDEYL 602
                 ||..|.|:             |.|.....|    :|....|.||:.|..|
Frog   565 SEKPVRLDTPSVVPNLEDVRSVFTTLQHDDTTDKPIHHDNPATKTLHLSHSDTLL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/23 (13%)
		LRR_8	109..169	CDD:290566	15/84 (18%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	6/46 (13%)
		leucine-rich repeat	159..183	CDD:275380	8/24 (33%)
		leucine-rich repeat	184..209	CDD:275380	8/25 (32%)
		LRR_8	205..266	CDD:290566	18/60 (30%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	54/163 (33%)
		leucine-rich repeat	256..276	CDD:275380	9/22 (41%)
		LRR_8	279..359	CDD:290566	32/82 (39%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	19/46 (41%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		PP2Cc	461..655	CDD:294085	41/204 (20%)
tril	XP_002933436.2	leucine-rich repeat	35..58	CDD:275378	5/34 (15%)
		leucine-rich repeat	59..82	CDD:275380	6/23 (26%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		internalin_A	84..>375	CDD:380193	87/309 (28%)
		leucine-rich repeat	107..130	CDD:275380	1/22 (5%)
		leucine-rich repeat	131..154	CDD:275380	8/24 (33%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	5/23 (22%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		leucine-rich repeat	227..250	CDD:275380	9/25 (36%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		leucine-rich repeat	275..298	CDD:275380	12/22 (55%)
		leucine-rich repeat	299..320	CDD:275380	6/20 (30%)
		leucine-rich repeat	323..346	CDD:275380	12/33 (36%)
		fn3	662..737	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910