DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrfn3

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_017951836.1	Gene:	lrfn3 / 100497711	XenbaseID:	XB-GENE-923381	Length:	632	Species:	Xenopus tropicalis

Alignment Length:	779	Identity:	144/779 - (18%)
Similarity:	242/779 - (31%)	Gaps:	289/779 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 QLEVCENEMEVL---DLSSLAQLETLKCSRNKLMELI---------------------------I 106
            :|.:.:|.:..|   |.:::..|..|..|||.:.:::                           :
Frog    55 ELRLMDNFITTLRRRDFANMTDLIHLTLSRNTISQIMPYAFVDLKGLHALHLDSNRLTSVSEEHL 119

  Fly   107 NG-TNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNW--VGACASLTAINASHNR 168
            .| .||:.|:..:|.||.|:..:.......|:.:|:|:||..::| |  :|..:|:..:...||
Frog   120 RGLINLRHLILSNNQLHYIAPGSFDDFVDTLEDLDLSYNNLVDIP-WETIGRLSSVNTVGLDHN- 182

  Fly   169 LNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEG-FSSIRS---LQLQSNELPSL-PDNFFAVT 228
                                       .:|..||| ||::..   |.:.||:|..: ||..|
Frog   183 ---------------------------LIDYVPEGIFSNLHKLARLDMTSNKLKKIPPDPLF--- 217

  Fly   229 HARLETLNVSCNKLSTLPRYEQNNHAALVN--LSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIG 291
                          |.:|.|.::..:.|.:  ||..||        |||
Frog   218 --------------SRIPVYAKSKGSPLTSLVLSFGGN--------PLH---------------- 244

  Fly   292 VLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSH 356
               ..|...|            |::|..|             ::|..|..
Frog   245 ---CNCELMW------------LRRLTRE-------------DDLETCAS--------------- 266

  Fly   357 NHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQ--SQRHWSLVDVSGNNRAAL---- 415
                        |:      :|.|.....:.|::| ||:..  :.|...||.:.|.: |:|
Frog   267 ------------PA------ELMGKYFWSIKEEEF-VCEPPMITHRTSKLVIMEGQS-ASLKCKS 311

  Fly   416 ---PTTKIRQVSAQ----RNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYG-----GSDEA 468
               |...:|.:|..    .|.::|.            |.|...|.:.....|:.|     .|:.|
Frog   312 VGDPDPYVRWISPDGKLVSNTSRTM------------SYDNGTLDIITTIYADRGNFTCIASNAA 364

  Fly   469 LYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHL-- 531
                     |...|..|::                    ...|..||....|.....:.|..:
Frog   365 ---------GESTANVELT--------------------VNPFPNLANSTNCDKETESGLSDILT 400

  Fly   532 -TRTRAP-SKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELI 594
             .::..| |:.:.|..|:.|:...::   .:.||:...|..:....:.|.....|..|..:..:|
Frog   401 PAKSSIPSSETKALNDKKVVVAELTS---SSALIQWPPQSHIPGIRMYQIQYNSSSDDILIYRMI 462

  Fly   595 LSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIA-----QSFAAAESL------ 648
            .|:...:.:   :.|.|..:.|.....:..:..:.|.|.|::...     |.:....||
Frog   463 PSSSKSFFL---SDLVSSRNYDLCVLAVYDDGTTALTATRVIGCVQFTTEQEYKQCRSLHAQFLG 524

  Fly   649 -------------SVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNA 700
                         ||:|..|          |..:|..|... .|.|.|....:||.:|....|..
Frog   525 GTMIIIIGGIIVASVLVFIF----------ILLMKYKVYNN-HPKSKPAKVTNVCSQTNGSHSGT 578

  Fly   701 CRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARV-LQEEQQLEMLDETESVSESVLS 763
                       .||||......||.|.:|.....|.....| |..:.:...|.:|..::..|||
Frog   579 -----------MGRSSSKLTERRDSLLQDISGTSVKGKTIVDLSPDGERVTLSDTTFITNDVLS 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/46 (13%)
		LRR_8	109..169	CDD:290566	18/61 (30%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	8/23 (35%)
		leucine-rich repeat	159..183	CDD:275380	2/23 (9%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	16/66 (24%)
		leucine-rich repeat	210..230	CDD:275380	7/20 (35%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	25/157 (16%)
		leucine-rich repeat	256..276	CDD:275380	7/21 (33%)
		LRR_8	279..359	CDD:290566	7/79 (9%)
		leucine-rich repeat	280..303	CDD:275380	2/22 (9%)
		leucine-rich repeat	304..348	CDD:275380	5/43 (12%)
		leucine-rich repeat	349..372	CDD:275380	1/22 (5%)
		PP2Cc	461..655	CDD:294085	36/226 (16%)
lrfn3	XP_017951836.1	LRR_8	55..111	CDD:338972	9/55 (16%)
		leucine-rich repeat	55..76	CDD:275380	4/20 (20%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..160	CDD:338972	12/59 (20%)
		leucine-rich repeat	101..124	CDD:275380	1/22 (5%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	149..208	CDD:338972	20/87 (23%)
		leucine-rich repeat	150..173	CDD:275380	8/23 (35%)
		leucine-rich repeat	174..197	CDD:275380	8/50 (16%)
		leucine-rich repeat	198..233	CDD:275380	11/51 (22%)
		TPKR_C2	241..>270	CDD:387596	12/113 (11%)
		Ig	302..375	CDD:386229	18/114 (16%)
		fn3	419..491	CDD:365830	12/77 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910