DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and phlpp1

DIOPT Version :10

Sequence 1:NP_609938.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_004915365.2 Gene:phlpp1 / 100497530 XenbaseID:XB-GENE-6458029 Length:1533 Species:Xenopus tropicalis


Alignment Length:846 Identity:211/846 - (24%)
Similarity:372/846 - (43%) Gaps:149/846 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            ::|||::.:|::..||:::|:.||.|.|.||:|..|.|:|..|:.|.|..|.|.|:   :.:|.|
 Frog   636 HITQLDLRDNKLTDLDVTALSNLEVLHCERNRLRCLKISGFFLKALYASSNELLNL---DVYPNP 697

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLD 198
            ..|..:|||.|....||.|.....:|..::.|||.||.:..  |.:..:.|..|.|.||.|::|.
 Frog   698 CYLSYMDISRNCLHSLPEWFSESRNLEVLDVSHNHLNELPD--RLFCTSALRKLLLGYNQLQRLP 760

  Fly   199 QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPR--YEQNNHAALVNLSL 261
            :..|. :.:..|.:|.|:|..||.|.....:: |..||.|.|.|.|||.  ..:.:|:.|..|.|
 Frog   761 ELIEN-NQLEVLDVQHNQLLELPANLLLKLNS-LRCLNASANHLETLPATCLSEESHSMLQELYL 823

  Fly   262 AGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQ 326
            ..|:|.|.....|.....|::||:|:|.:...||:.:....|||.:.:|||.|:.:|..:....:
 Frog   824 TNNNLTDKCVPLLMGHPHLKILHMAFNHLQTFPASKMAKLEELEEIDISGNKLKAMPTTIMNCRR 888

  Fly   327 LRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQF 391
            :..:...:|.|...|::.:|:.:|.:|||.|.|..:.|...:|.| |:.|||:||.:|.:|.:..
 Frog   889 MHTVIAHSNCLEVFPEVMQLSEIKCVDLSCNELTEITLPENLPPR-LQELDLTGNARLLLDHKTL 952

  Fly   392 KVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSG---PWTMGFAETPGSGDCRKLS 453
            ::..|.                 :...|:.|.|...:.::.||   .|:.|:||  .||...||.
 Frog   953 ELLNSN-----------------IRFLKVDQPSCGFSGSEASGVPAVWSHGYAE--ASGVKSKLC 998

  Fly   454 VYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMK-------QEQMVKDSAVRDYMKF 511
            |..|...|:..:.||:||:|:.         |.:..||.|::       .:::.|..:..:||..
 Frog   999 VASLLVNNFCDNREAVYGVFDG---------ERNVEVPSLLQCTMSDILADELQKTKSEEEYMGN 1054

  Fly   512 TLLAAQQQCGSV-----RSAALFHLTRTRAPSKVRPL-KSKRYVLRMASTGGLDAYLIRRTSQLR 570
            |.|..|::.|:.     .||.|.|:       |..|: .:..:.|..|:.|.....:.|....|.
 Frog  1055 TFLVMQRKLGTAGQKLGGSAVLCHI-------KHDPMDPAGCFTLTTANVGKCQTVICRDGKPLN 1112

  Fly   571 LTK----------------PDVIQKDQ----------------IHS--MPDPHVLELILSNDDEY 601
            |:|                ..:|.:|.                :|.  .|.|||..:.|:..||:
 Frog  1113 LSKHLTVSCEEELKRIKQHKAIITEDGKVNGVTDSTRILGYTFLHPSVTPRPHVQSVTLTPQDEF 1177

  Fly   602 LVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTD----- 661
            .::|:..||..:.::.|...:|...::|.|:|:|..:|||:..:.||..:||:. ::..|     
 Frog  1178 FILGSKGLWDSLSMEEAVETVRNVPDALAASKKLCSLAQSYGCSGSLCAVVVQL-NVTEDCICCC 1241

  Fly   662 -----------------VDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAI--- 706
                             |:.:|::      :.|..:.:|.||..:......:.|.:.....:   
 Frog  1242 ELNGGMPPPSPGIFTPSVNVVIKD------RAPDSLGMPSSSSGLASEISSEISTSEMSSEVGST 1300

  Fly   707 -EQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQE--EQQLEMLDETESVSESVLSEEQFK 768
             ..||.|.....:|........:.:    ...|...|..  ::||.....:.:.|::.|..|..:
 Frog  1301 ASDEPPAVSLHENGVGPVGCPTEQR----CTLHPVCLSSSFQRQLSSATFSSAFSDNGLDSEDEE 1361

  Fly   769 CWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAAT----VL----------PERNDFTSNL 819
            ..|.:....:::..:.::: .|::.:..:|||..:..:|    |:          .:|.||:||.
 Frog  1362 PIEGVFSNGSRVEVEVDIH-CSRTKSGCQTVPAVLTESTDEGIVINGNEDDMGGPGKRQDFSSNT 1425

  Fly   820 M 820
            :
 Frog  1426 L 1426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_609938.1 LRR 82..>381 CDD:443914 100/300 (33%)
leucine-rich repeat 91..110 CDD:275380 10/18 (56%)
leucine-rich repeat 111..135 CDD:275380 8/23 (35%)
leucine-rich repeat 136..158 CDD:275380 8/21 (38%)
leucine-rich repeat 159..183 CDD:275380 7/23 (30%)
leucine-rich repeat 184..209 CDD:275380 8/24 (33%)
leucine-rich repeat 210..230 CDD:275380 7/19 (37%)
leucine-rich repeat 232..255 CDD:275380 10/24 (42%)
leucine-rich repeat 256..276 CDD:275380 7/19 (37%)
leucine-rich repeat 280..303 CDD:275380 7/22 (32%)
leucine-rich repeat 304..348 CDD:275380 11/43 (26%)
leucine-rich repeat 349..372 CDD:275380 8/22 (36%)
PP2Cc 461..655 CDD:469621 56/240 (23%)
phlpp1XP_004915365.2 RA_PHLPP1 136..332 CDD:340760
PH_PHLPP-like 339..435 CDD:270131
leucine-rich repeat 443..465 CDD:275380
LRR <444..773 CDD:443914 49/142 (35%)
leucine-rich repeat 466..496 CDD:275380
leucine-rich repeat 497..519 CDD:275380
leucine-rich repeat 520..542 CDD:275380
leucine-rich repeat 543..565 CDD:275380
leucine-rich repeat 566..603 CDD:275380
leucine-rich repeat 614..636 CDD:275380 211/846 (25%)
leucine-rich repeat 638..657 CDD:275380 7/18 (39%)
leucine-rich repeat 658..699 CDD:275380 18/43 (42%)
leucine-rich repeat 700..722 CDD:275380 8/21 (38%)
LRR <712..>956 CDD:443914 78/248 (31%)
leucine-rich repeat 723..745 CDD:275380 7/23 (30%)
leucine-rich repeat 746..767 CDD:275380 8/21 (38%)
leucine-rich repeat 768..791 CDD:275380 7/22 (32%)
leucine-rich repeat 792..815 CDD:275380 9/22 (41%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
leucine-rich repeat 911..933 CDD:275380 8/21 (38%)
PP2Cc 980..1229 CDD:214625 64/266 (24%)
Blue background indicates that the domain is not in the aligned region.

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