DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and phlpp1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_004915365.2	Gene:	phlpp1 / 100497530	XenbaseID:	XB-GENE-6458029	Length:	1533	Species:	Xenopus tropicalis

Alignment Length:	846	Identity:	211/846 - (24%)
Similarity:	372/846 - (43%)	Gaps:	149/846 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            ::|||::.:|::..||:::|:.||.|.|.||:|..|.|:|..|:.|.|..|.|.|:   :.:|.|
Frog   636 HITQLDLRDNKLTDLDVTALSNLEVLHCERNRLRCLKISGFFLKALYASSNELLNL---DVYPNP 697

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLD 198
            ..|..:|||.|....||.|.....:|..::.|||.||.:..  |.:..:.|..|.|.||.|::|.
Frog   698 CYLSYMDISRNCLHSLPEWFSESRNLEVLDVSHNHLNELPD--RLFCTSALRKLLLGYNQLQRLP 760

  Fly   199 QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPR--YEQNNHAALVNLSL 261
            :..|. :.:..|.:|.|:|..||.|.....:: |..||.|.|.|.|||.  ..:.:|:.|..|.|
Frog   761 ELIEN-NQLEVLDVQHNQLLELPANLLLKLNS-LRCLNASANHLETLPATCLSEESHSMLQELYL 823

  Fly   262 AGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQ 326
            ..|:|.|.....|.....|::||:|:|.:...||:.:....|||.:.:|||.|:.:|..:....:
Frog   824 TNNNLTDKCVPLLMGHPHLKILHMAFNHLQTFPASKMAKLEELEEIDISGNKLKAMPTTIMNCRR 888

  Fly   327 LRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQF 391
            :..:...:|.|...|::.:|:.:|.:|||.|.|..:.|...:|.| |:.|||:||.:|.:|.:..
Frog   889 MHTVIAHSNCLEVFPEVMQLSEIKCVDLSCNELTEITLPENLPPR-LQELDLTGNARLLLDHKTL 952

  Fly   392 KVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSG---PWTMGFAETPGSGDCRKLS 453
            ::..|.                 :...|:.|.|...:.::.||   .|:.|:||  .||...||.
Frog   953 ELLNSN-----------------IRFLKVDQPSCGFSGSEASGVPAVWSHGYAE--ASGVKSKLC 998

  Fly   454 VYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMK-------QEQMVKDSAVRDYMKF 511
            |..|...|:..:.||:||:|:.         |.:..||.|::       .:::.|..:..:||..
Frog   999 VASLLVNNFCDNREAVYGVFDG---------ERNVEVPSLLQCTMSDILADELQKTKSEEEYMGN 1054

  Fly   512 TLLAAQQQCGSV-----RSAALFHLTRTRAPSKVRPL-KSKRYVLRMASTGGLDAYLIRRTSQLR 570
            |.|..|::.|:.     .||.|.|:       |..|: .:..:.|..|:.|.....:.|....|.
Frog  1055 TFLVMQRKLGTAGQKLGGSAVLCHI-------KHDPMDPAGCFTLTTANVGKCQTVICRDGKPLN 1112

  Fly   571 LTK----------------PDVIQKDQ----------------IHS--MPDPHVLELILSNDDEY 601
            |:|                ..:|.:|.                :|.  .|.|||..:.|:..||:
Frog  1113 LSKHLTVSCEEELKRIKQHKAIITEDGKVNGVTDSTRILGYTFLHPSVTPRPHVQSVTLTPQDEF 1177

  Fly   602 LVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTD----- 661
            .::|:..||..:.::.|...:|...::|.|:|:|..:|||:..:.||..:||:. ::..|
Frog  1178 FILGSKGLWDSLSMEEAVETVRNVPDALAASKKLCSLAQSYGCSGSLCAVVVQL-NVTEDCICCC 1241

  Fly   662 -----------------VDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAI--- 706
                             |:.:|::      :.|..:.:|.||..:......:.|.:.....:
Frog  1242 ELNGGMPPPSPGIFTPSVNVVIKD------RAPDSLGMPSSSSGLASEISSEISTSEMSSEVGST 1300

  Fly   707 -EQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQE--EQQLEMLDETESVSESVLSEEQFK 768
             ..||.|.....:|........:.:    ...|...|..  ::||.....:.:.|::.|..|..:
Frog  1301 ASDEPPAVSLHENGVGPVGCPTEQR----CTLHPVCLSSSFQRQLSSATFSSAFSDNGLDSEDEE 1361

  Fly   769 CWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAAT----VL----------PERNDFTSNL 819
            ..|.:....:::..:.::: .|::.:..:|||..:..:|    |:          .:|.||:||.
Frog  1362 PIEGVFSNGSRVEVEVDIH-CSRTKSGCQTVPAVLTESTDEGIVINGNEDDMGGPGKRQDFSSNT 1425

  Fly   820 M 820
            :
Frog  1426 L 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	10/18 (56%)
		LRR_8	109..169	CDD:290566	20/59 (34%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	8/21 (38%)
		leucine-rich repeat	159..183	CDD:275380	7/23 (30%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	21/62 (34%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	10/24 (42%)
		LRR_RI	<256..410	CDD:238064	44/153 (29%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	24/79 (30%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	11/43 (26%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		PP2Cc	461..655	CDD:294085	56/240 (23%)
phlpp1	XP_004915365.2	RA_PHLPP1	136..332	CDD:340760
		PH_PHLPP-like	339..435	CDD:270131
		PLN00113	406..>930	CDD:215061	98/300 (33%)
		leucine-rich repeat	443..465	CDD:275380
		leucine-rich repeat	466..496	CDD:275380
		leucine-rich repeat	497..519	CDD:275380
		leucine-rich repeat	520..542	CDD:275380
		leucine-rich repeat	543..565	CDD:275380
		leucine-rich repeat	566..603	CDD:275380
		leucine-rich repeat	614..636	CDD:275380	211/846 (25%)
		leucine-rich repeat	638..657	CDD:275380	7/18 (39%)
		leucine-rich repeat	658..699	CDD:275380	18/43 (42%)
		leucine-rich repeat	700..722	CDD:275380	8/21 (38%)
		leucine-rich repeat	723..745	CDD:275380	7/23 (30%)
		leucine-rich repeat	746..767	CDD:275380	8/21 (38%)
		leucine-rich repeat	768..791	CDD:275380	7/22 (32%)
		leucine-rich repeat	792..815	CDD:275380	9/22 (41%)
		leucine-rich repeat	818..841	CDD:275380	7/22 (32%)
		leucine-rich repeat	842..865	CDD:275380	7/22 (32%)
		leucine-rich repeat	911..933	CDD:275380	8/21 (38%)
		PP2Cc	980..1229	CDD:214625	64/266 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8463
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	1	1.000	-	-		FOG0003647
OrthoInspector	1	1.000	-	-		otm48690
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.020