Protein Alignment Phlpp and shoc2

DIOPT Version :9

• Sequence 1: NP_001260558.1
• Gene: Phlpp / 35178
• FlyBaseID: FBgn0032749
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_031761665.1
• Gene: shoc2 / 100495610
• XenbaseID: XB-GENE-493502
• Length: 582
• Species: Xenopus tropicalis
• Alignment Length: 631
• Identity: 135/631 - (21%)
• Similarity: 222/631 - (35%)
• Gaps: 207/631 - (32%)

  Fly     1 MLKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQ----AATFGQTSPQKLSLK------- 54
            |..:..|:.||.:.:.||::            ||.|.|:    |....::..:.|..|
 Frog     1 MSSSVGKEKDPKEREPKVTS------------TAKEREKEAKAAGLVKESKDKDLKTKVKDAKEG 53

  Fly    55 -----GSQLGGSILI-----------------GNYNYLTQLEVCENEMEV-LDLS--SLAQLETL 94
                 |:|.|.:..:                 .|...:.:|..|..|... |||:  |:..|...
 Frog    54 KRDPIGAQAGVAFSVDNTIKRPNPASGMRKKASNAEVIKELSKCREENATRLDLAKKSIHMLPVS 118

  Fly    95 KCSRNKLMELIINGTNLQTLVADHNYLHN-----ISTTNTHPVP------LKLQRIDISHNNFSE 148
            .....::.||.:.|..||:|.|:...|.|     :|..:...:|      .||..:|:.||...|
 Frog   119 IKDLTQITELYLYGNKLQSLPAEVGCLVNLVKLALSENSLTSLPDSLDNLKKLCMLDLRHNKLRE 183

  Fly   149 LPNWVGACASLTAINASHNRLNNV-----------AVLLRNYRI----------TELVSLDLAYN 192
            :|..|...:|||.:....||:..|           .:.:|..:|          ..|::||:|:|
 Frog   184 IPAVVYRLSSLTTLFLRFNRITAVEKDIKTLSKLTMLSIRENKIKHLPAEIGELCNLITLDVAHN 248

  Fly   193 DLKQLDQFPEGFSSIRSLQLQSNELPSLPD---NFFAVTH------------------ARLETLN 236
            .|:.|.:.....:.|.:|.||.|||..|||   |..:::.                  :.|:.||
 Frog   249 QLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLCSLSRLGLRYNRLSAVPRSLAKCSELDELN 313

  Fly   237 VSCNKLSTLPR---------------------YE---QNNHAALVNLSLAGNHLNDSIFEPLHNA 277
            :..|.:||||.                     |.   .:..:.:.:|::..|.:|...|.....|
 Frog   314 LENNNISTLPEGLLSSLVKVNSLTLARNCFQSYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378

  Fly   278 AKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ 342
            ..|..|::..|::..||.. ...|..:..|.|:.|.|.::||:|:.|..:.||...||||...|.
 Frog   379 KVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSIEVLILSNNLLKKLPH 442

  Fly   343 -LAKLAMLKVLDLSHNHLDRV-----------------NLLALVPS-----RNLKYLDLSGNLQL 384
             :..|..|:.|||..|.|:.:                 |.|..:|.     .||.:|.|..||..
 Frog   443 GIGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT 507

  Fly   385 QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTK-IRQVSAQRNQNKTSGPWTMGFAETPGSGD 448
            .:.|:                         :.|.: :.::....|.|..|.|:.:..
 Frog   508 HLPEE-------------------------IGTLENLEELYLNDNPNLHSLPFELAL-------- 539

  Fly   449 CRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLM 494
            |.|||:..:...                        .:|||.|.::
 Frog   540 CSKLSIMSIENC------------------------PLSHLPPQIV 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	20/70 (29%)
		leucine-rich repeat	111..135	CDD:275380	8/34 (24%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	7/44 (16%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	22/105 (21%)
		leucine-rich repeat	210..230	CDD:275380	10/40 (25%)
		leucine-rich repeat	232..255	CDD:275380	9/46 (20%)
		LRR_RI	<256..410	CDD:238064	43/176 (24%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	27/80 (34%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	16/44 (36%)
		leucine-rich repeat	349..372	CDD:275380	9/44 (20%)
		PP2Cc	461..655	CDD:294085	4/34 (12%)
shoc2	XP_031761665.1	leucine-rich repeat	103..124	CDD:275380	5/20 (25%)
		PLN00113	115..>535	CDD:215061	102/445 (23%)
		leucine-rich repeat	125..147	CDD:275380	8/21 (38%)
		leucine-rich repeat	148..170	CDD:275380	2/21 (10%)
		leucine-rich repeat	171..193	CDD:275380	7/21 (33%)
		leucine-rich repeat	194..216	CDD:275380	5/21 (24%)
		leucine-rich repeat	217..239	CDD:275380	2/21 (10%)
		leucine-rich repeat	240..262	CDD:275380	7/21 (33%)
		leucine-rich repeat	264..285	CDD:275380	10/20 (50%)
		leucine-rich repeat	286..308	CDD:275380	0/21 (0%)
		leucine-rich repeat	309..335	CDD:275380	8/25 (32%)
		leucine-rich repeat	336..380	CDD:275380	6/43 (14%)
		leucine-rich repeat	381..403	CDD:275380	6/22 (27%)
		leucine-rich repeat	404..426	CDD:275380	8/21 (38%)
		leucine-rich repeat	427..449	CDD:275380	8/21 (38%)
		leucine-rich repeat	450..472	CDD:275380	6/21 (29%)
		leucine-rich repeat	473..495	CDD:275380	3/21 (14%)
		leucine-rich repeat	496..519	CDD:275380	7/47 (15%)
		leucine-rich repeat	543..563	CDD:275380	6/43 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910