DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and shoc2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_031761665.1 Gene:shoc2 / 100495610 XenbaseID:XB-GENE-493502 Length:582 Species:Xenopus tropicalis


Alignment Length:631 Identity:135/631 - (21%)
Similarity:222/631 - (35%) Gaps:207/631 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQ----AATFGQTSPQKLSLK------- 54
            |..:..|:.||.:.:.||::            ||.|.|:    |....::..:.|..|       
 Frog     1 MSSSVGKEKDPKEREPKVTS------------TAKEREKEAKAAGLVKESKDKDLKTKVKDAKEG 53

  Fly    55 -----GSQLGGSILI-----------------GNYNYLTQLEVCENEMEV-LDLS--SLAQLETL 94
                 |:|.|.:..:                 .|...:.:|..|..|... |||:  |:..|...
 Frog    54 KRDPIGAQAGVAFSVDNTIKRPNPASGMRKKASNAEVIKELSKCREENATRLDLAKKSIHMLPVS 118

  Fly    95 KCSRNKLMELIINGTNLQTLVADHNYLHN-----ISTTNTHPVP------LKLQRIDISHNNFSE 148
            .....::.||.:.|..||:|.|:...|.|     :|..:...:|      .||..:|:.||...|
 Frog   119 IKDLTQITELYLYGNKLQSLPAEVGCLVNLVKLALSENSLTSLPDSLDNLKKLCMLDLRHNKLRE 183

  Fly   149 LPNWVGACASLTAINASHNRLNNV-----------AVLLRNYRI----------TELVSLDLAYN 192
            :|..|...:|||.:....||:..|           .:.:|..:|          ..|::||:|:|
 Frog   184 IPAVVYRLSSLTTLFLRFNRITAVEKDIKTLSKLTMLSIRENKIKHLPAEIGELCNLITLDVAHN 248

  Fly   193 DLKQLDQFPEGFSSIRSLQLQSNELPSLPD---NFFAVTH------------------ARLETLN 236
            .|:.|.:.....:.|.:|.||.|||..|||   |..:::.                  :.|:.||
 Frog   249 QLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLCSLSRLGLRYNRLSAVPRSLAKCSELDELN 313

  Fly   237 VSCNKLSTLPR---------------------YE---QNNHAALVNLSLAGNHLNDSIFEPLHNA 277
            :..|.:||||.                     |.   .:..:.:.:|::..|.:|...|.....|
 Frog   314 LENNNISTLPEGLLSSLVKVNSLTLARNCFQSYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378

  Fly   278 AKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ 342
            ..|..|::..|::..||.. ...|..:..|.|:.|.|.::||:|:.|..:.||...||||...|.
 Frog   379 KVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSIEVLILSNNLLKKLPH 442

  Fly   343 -LAKLAMLKVLDLSHNHLDRV-----------------NLLALVPS-----RNLKYLDLSGNLQL 384
             :..|..|:.|||..|.|:.:                 |.|..:|.     .||.:|.|..||..
 Frog   443 GIGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT 507

  Fly   385 QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTK-IRQVSAQRNQNKTSGPWTMGFAETPGSGD 448
            .:.|:                         :.|.: :.::....|.|..|.|:.:..        
 Frog   508 HLPEE-------------------------IGTLENLEELYLNDNPNLHSLPFELAL-------- 539

  Fly   449 CRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLM 494
            |.|||:..:...                        .:|||.|.::
 Frog   540 CSKLSIMSIENC------------------------PLSHLPPQIV 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 4/18 (22%)
LRR_8 109..169 CDD:290566 20/70 (29%)
leucine-rich repeat 111..135 CDD:275380 8/34 (24%)
leucine-rich repeat 136..158 CDD:275380 7/21 (33%)
leucine-rich repeat 159..183 CDD:275380 7/44 (16%)
leucine-rich repeat 184..209 CDD:275380 8/24 (33%)
LRR_8 205..266 CDD:290566 22/105 (21%)
leucine-rich repeat 210..230 CDD:275380 10/40 (25%)
leucine-rich repeat 232..255 CDD:275380 9/46 (20%)
LRR_RI <256..410 CDD:238064 43/176 (24%)
leucine-rich repeat 256..276 CDD:275380 4/19 (21%)
LRR_8 279..359 CDD:290566 27/80 (34%)
leucine-rich repeat 280..303 CDD:275380 6/22 (27%)
leucine-rich repeat 304..348 CDD:275380 16/44 (36%)
leucine-rich repeat 349..372 CDD:275380 9/44 (20%)
PP2Cc 461..655 CDD:294085 4/34 (12%)
shoc2XP_031761665.1 leucine-rich repeat 103..124 CDD:275380 5/20 (25%)
PLN00113 115..>535 CDD:215061 102/445 (23%)
leucine-rich repeat 125..147 CDD:275380 8/21 (38%)
leucine-rich repeat 148..170 CDD:275380 2/21 (10%)
leucine-rich repeat 171..193 CDD:275380 7/21 (33%)
leucine-rich repeat 194..216 CDD:275380 5/21 (24%)
leucine-rich repeat 217..239 CDD:275380 2/21 (10%)
leucine-rich repeat 240..262 CDD:275380 7/21 (33%)
leucine-rich repeat 264..285 CDD:275380 10/20 (50%)
leucine-rich repeat 286..308 CDD:275380 0/21 (0%)
leucine-rich repeat 309..335 CDD:275380 8/25 (32%)
leucine-rich repeat 336..380 CDD:275380 6/43 (14%)
leucine-rich repeat 381..403 CDD:275380 6/22 (27%)
leucine-rich repeat 404..426 CDD:275380 8/21 (38%)
leucine-rich repeat 427..449 CDD:275380 8/21 (38%)
leucine-rich repeat 450..472 CDD:275380 6/21 (29%)
leucine-rich repeat 473..495 CDD:275380 3/21 (14%)
leucine-rich repeat 496..519 CDD:275380 7/47 (15%)
leucine-rich repeat 543..563 CDD:275380 6/43 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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