DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrfn5

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002941802.2	Gene:	lrfn5 / 100495182	XenbaseID:	XB-GENE-923445	Length:	775	Species:	Xenopus tropicalis

Alignment Length:	963	Identity:	191/963 - (19%)
Similarity:	314/963 - (32%)	Gaps:	323/963 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EVCENEMEVLDLSSLAQLETLKCSRNKLMEL--IINGTNLQTLVADHNYLHNISTTN----THPV 132
            |:|.......:||  ..|.|| |.:..|:.:  .||...::..:|| |::.:|...:    |..|
Frog    18 EICPKRCACQNLS--PNLATL-CDKKGLLFVPPNINRKTVELRLAD-NFVTSIKRKDFANMTSLV 78

  Fly   133 PLKLQRIDISH---NNFSELPNWVGACASLTAINASHNRLNNVA------------VLLRNYRIT 182
            .|.|.|..||:   :.||:|.|       |.|::.:.|||..||            ::|.|.::|
Frog    79 DLTLSRNTISYITPHAFSDLRN-------LRALHLNSNRLTRVANDMFSGLLNLHHLILNNNQLT 136

  Fly   183 -----------ELVSLDLAYNDLKQLD-QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETL 235
                       .|..|||:||:|:.:. ...|...|:.:|.|..|.:..:|...|:..| :|..|
Frog   137 LISSTAFDDVLALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIEHIPKGTFSHLH-KLNRL 200

  Fly   236 NVSCNKLSTLP------RYEQNNHAALVN-----LSLAGNHLNDSIFEPLHNAAKLRVLHLAYNR 289
            :|:.|||..||      |.:....:.:::     ||..||        |||...:|..|......
Frog   201 DVTSNKLQKLPPDPLFQRAQVLVTSGIISSSTFALSFGGN--------PLHCNCELLWLRRLLRE 257

  Fly   290 IGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAK--LAMLKVL 352
            ..:...|.    |.|    |||.....:.||.               .||.|.|..  ...|:||
Frog   258 DDLETCAS----PPL----LSGRYFWSITEEE---------------FLCEPPLITRYTQELRVL 299

  Fly   353 DLSHNHLDRVNLLA--------LVPSRNLKYLDLSGNLQLQV-DEQQFKVCQSQSQRHWSLVDVS 408
            :.....| |...|.        :.|...|    :|...::.| |.....:..:..:...|...::
Frog   300 EGQRATL-RCKALGDPEPAIHWISPESKL----ISNGTRILVYDNGTLDILITTVKDTGSFSCIA 359

  Fly   409 GNNRAALPTTK------IRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDE 467
            .|  .|..|||      |:......:.|....|       .|||.|        :..:...||:.
Frog   360 SN--PAGETTKTSVLHIIKLPHLVNSTNHIQEP-------DPGSSD--------ISTSTKSGSNA 407

  Fly   468 ALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLT 532
            :      :..|..:..|:...:|.:......::|.:..|:.....:...|.. |:...:.::.:.
Frog   408 S------SSNGDTKITQDKKVVVAEATSSTVLIKFNFQRNIPGIRMFQIQYN-GTYDDSLVYRMI 465

  Fly   533 RTRAPSKVRPLKSKRYVLRMASTGGL-DAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILS 596
                     |..||.:.:...:.|.| |..::            .|..|.|.|:....
Frog   466 ---------PPTSKTFRVNNLAAGTLYDLCVL------------AIYDDGITSLTATR------- 502

  Fly   597 NDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFR----- 656
                  |||..|..:..|..|.    ...::..|....::.|.....|:..:.:|::..|
Frog   503 ------VVGCIQFTTEQDYVRC----HFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCN 557

  Fly   657 ----HLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSP 717
                |..|.|.::..:                ::||        ::.:|           ..|.|
Frog   558 GNGHHKATKVSNVYSQ----------------TNGS--------QNQSC-----------SSSVP 587

  Fly   718 SGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLS-EEQFKCWEYMLEQNTQLL 781
            |                                     |||:.|:. ||..:|.:...|...|
Frog   588 S-------------------------------------SVSKQVVGHEESSQCCKVSAESGAQ-- 613

  Fly   782 FDKELNTISKSFTKQRTVPNAIMA-----------------ATVL---PERNDFTSNLMRTVTNK 826
                    |......:.||:...|                 .|||   ..:.|...|:....||:
Frog   614 --------SSDTCPSQDVPSTTSALSHTWTASTSASLKQKRKTVLKPMDSQTDTVLNIESQNTNR 670

  Fly   827 FISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFD-------AKPRPKF 884
            ..||:. :||     :.|.||   :|:||        .:::|.|.......       ||.|..|
Frog   671 NNSTAL-RLP-----TCPYGS---IKEAP--------VYKRAQSKPSKFLTLPAETSRAKRRYSF 718

  Fly   885 HGGTVKRSAGPNSAYFGSL--QRLMPYNFEYDFAVTQERERNILDEEEHDDDD 935
            :|..::.....|:...|.|  :|.|..|             .||.:.::.|.|
Frog   719 NGEVMEYHCYVNTYNTGGLWSKRSMSMN-------------GILVQSDNSDMD 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/20 (35%)
		LRR_8	109..169	CDD:290566	18/66 (27%)
		leucine-rich repeat	111..135	CDD:275380	6/27 (22%)
		leucine-rich repeat	136..158	CDD:275380	8/24 (33%)
		leucine-rich repeat	159..183	CDD:275380	10/46 (22%)
		leucine-rich repeat	184..209	CDD:275380	9/25 (36%)
		LRR_8	205..266	CDD:290566	20/71 (28%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	9/28 (32%)
		LRR_RI	<256..410	CDD:238064	33/169 (20%)
		leucine-rich repeat	256..276	CDD:275380	6/24 (25%)
		LRR_8	279..359	CDD:290566	17/81 (21%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	10/45 (22%)
		leucine-rich repeat	349..372	CDD:275380	7/30 (23%)
		PP2Cc	461..655	CDD:294085	29/194 (15%)
lrfn5	XP_002941802.2	leucine-rich repeat	53..76	CDD:275380	4/23 (17%)
		LRR_8	55..111	CDD:404697	18/63 (29%)
		leucine-rich repeat	77..100	CDD:275380	9/22 (41%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	3/22 (14%)
		LRR_8	149..207	CDD:404697	19/58 (33%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	6/23 (26%)
		leucine-rich repeat	197..215	CDD:275380	8/17 (47%)
		leucine-rich repeat	222..244	CDD:275378	6/29 (21%)
		Ig	287..374	CDD:416386	18/93 (19%)
		Ig strand A	287..290	CDD:409353	1/2 (50%)
		Ig strand A'	294..297	CDD:409353	0/2 (0%)
		Ig strand B	303..311	CDD:409353	2/8 (25%)
		Ig strand C	317..322	CDD:409353	0/4 (0%)
		Ig strand C'	325..327	CDD:409353	0/1 (0%)
		Ig strand D	333..337	CDD:409353	0/3 (0%)
		Ig strand E	340..344	CDD:409353	0/3 (0%)
		Ig strand F	354..361	CDD:409353	1/6 (17%)
		Ig strand G	364..374	CDD:409353	3/9 (33%)
		FN3	422..495	CDD:419708	13/94 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910