DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrfn2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_031758515.1	Gene:	lrfn2 / 100491687	XenbaseID:	XB-GENE-6035533	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	816	Identity:	176/816 - (21%)
Similarity:	270/816 - (33%)	Gaps:	278/816 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QLGGSILI-------GNYNYLTQLEVCENEMEVLDLSSLAQLETLK---CSRNKLMEL---IING 108
            :|||:.:|       .|...|..|.:..|.:..:...|...||:|:   ...|:|..|   :..|
Frog    57 RLGGNFIISINRQDFANMTGLVDLTLSRNTISYIQPYSFIDLESLRSLHLDSNRLTNLGDDVFRG 121

  Fly   109 -TNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNW--VGACASLTAINASHNRLN 170
             .|||.|:.::|.|::|:......:...|:.:|:|:||...:| |  |....:|..::..||.:
Frog   122 LINLQHLIMNNNQLNSIAEDAFEDLLQTLEDLDLSYNNLKTVP-WDAVRRMVNLHQLSLDHNLI- 184

  Fly   171 NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSL-PDNFFAVTHARLET 234
                    |.|||....||  |.|.:||             |.||.|..| ||..||.:...:.:
Frog   185 --------YYITEGTFQDL--NKLARLD-------------LTSNRLQKLPPDPIFARSQISMTS 226

  Fly   235 LNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIG-------- 291
            .......||               ||..||        |||...:|    |...|:.
Frog   227 ATPFSPPLS---------------LSFGGN--------PLHCNCEL----LWLRRLDREDDMETC 264

  Fly   292 VLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSH 356
            ..|:|            |.|.....:.||........:.:....||:...|.|.|....|.|
Frog   265 ASPSA------------LKGRYFWYVREEEFVCEPPLITQYTQRLLVLEGQTASLKCKAVGD--- 314

  Fly   357 NHLDRVNLLA----LV--PSRNLKY----LDL------------------SGNLQLQVDEQQFKV 393
             .|..::.:|    |:  .||...|    ||:                  :|.|...|:
Frog   315 -PLPVIHWVAPDGRLIGNSSRTTVYDNGTLDILITTSKDYGTFTCIAANAAGELTAPVE------ 372

  Fly   394 CQSQSQRHWSLVDV----SGNNRAALPTTKIRQVSAQRNQN----KTSGPWTMGFAETPGSGDCR 450
                    .|:|.:    :|..|.|.|.:::..:::....|    ||:....:..:|...|....
Frog   373 --------LSIVQIPHVSNGTGRTAPPKSRLSDITSSTKSNRGEVKTAPEKAVVVSEVTSSTALV 429

  Fly   451 KLSV---------YQLRAANYGGSDE--ALYGMFEALEGRGRAAQEMSHLVP----DLMKQEQMV 500
            |.||         |||:   |..||:  .:|.|..|    ...|..:::||.    ||..
Frog   430 KWSVSKAAPKVKMYQLQ---YNCSDDEVLIYRMIPA----SNKAFVVNNLVSGTAYDLCV----- 482

  Fly   501 KDSAVRDYMKFTLLAAQ-------------QQCGSVRSAALFH---------LTRTRAPSKVRPL 543
              .|:.|....||.|..             |||.|:.|..|..         :..|.....|  :
Frog   483 --LAIWDDTATTLTATNIVGCAQFFTQEDYQQCQSMHSQFLGGTMILVIGGIIVATLLVFIV--I 543

  Fly   544 KSKRYVLRMASTGGLDAYLIRRTSQLR-----------LTKPDVIQKDQI--------HSMPDPH 589
            ...||.:...|.|.: |.:....||..           .|.|.|:.::::        ||.....
Frog   544 LMVRYKICNHSQGKM-ANVTNVYSQTNGGNTVQNGAPPQTNPKVVVRNELMEFQCGSAHSSVSSS 607

  Fly   590 VLELILSNDDEYLVVGN----AQLW-----SVMDIDR-----AAREIR--KEENSLLAAKRLVDI 638
            ...:...:.|:|.:..|    :..|     |..:|||     |:.|:|  |:|::       ||.
Frog   608 SSSVNSPDGDDYSLHSNPSTLSNKWRPVSRSKHNIDRLMGAFASLELRCQKKEDT-------VDS 665

  Fly   639 AQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSS----------GSVCKRT 693
            ..|..|.:|             |.:.|:...:..||..   :.|||..          |......
Frog   666 RTSTTAHQS-------------DKEPLLGHHESKVRSL---LMLPLEGKAKRSHSFDMGDFSTTQ 714

  Fly   694 CCDR----SNACRHRAIE---------QEPLAGRSS 716
            ||..    ||....|::.         ...|||.::
Frog   715 CCSYPRKISNIWTRRSLSVNGMLLQYTDSELAGNAT 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/25 (28%)
		LRR_8	109..169	CDD:290566	18/61 (30%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	8/23 (35%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	6/24 (25%)
		LRR_8	205..266	CDD:290566	15/61 (25%)
		leucine-rich repeat	210..230	CDD:275380	9/20 (45%)
		leucine-rich repeat	232..255	CDD:275380	2/22 (9%)
		LRR_RI	<256..410	CDD:238064	36/193 (19%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	16/87 (18%)
		leucine-rich repeat	280..303	CDD:275380	5/30 (17%)
		leucine-rich repeat	304..348	CDD:275380	9/43 (21%)
		leucine-rich repeat	349..372	CDD:275380	6/28 (21%)
		PP2Cc	461..655	CDD:294085	54/256 (21%)
lrfn2	XP_031758515.1	LRR_8	51..111	CDD:404697	13/53 (25%)
		leucine-rich repeat	53..76	CDD:275380	5/18 (28%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..160	CDD:404697	16/59 (27%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	148..208	CDD:404697	24/84 (29%)
		leucine-rich repeat	150..173	CDD:275380	8/23 (35%)
		leucine-rich repeat	174..197	CDD:275380	9/33 (27%)
		LRRCT	241..285	CDD:214507	13/67 (19%)
		Ig	288..375	CDD:416386	18/104 (17%)
		Ig strand A	288..291	CDD:409353	0/2 (0%)
		Ig strand A'	295..298	CDD:409353	0/2 (0%)
		Ig strand B	304..312	CDD:409353	2/7 (29%)
		Ig strand C	318..323	CDD:409353	0/4 (0%)
		Ig strand C'	326..328	CDD:409353	0/1 (0%)
		Ig strand D	334..338	CDD:409353	1/3 (33%)
		Ig strand E	341..345	CDD:409353	1/3 (33%)
		Ig strand F	355..362	CDD:409353	0/6 (0%)
		Ig strand G	365..375	CDD:409353	3/23 (13%)
		fn3	417..485	CDD:394996	19/81 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910