DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and chadl

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002934783.2	Gene:	chadl / 100491048	XenbaseID:	XB-GENE-6050564	Length:	721	Species:	Xenopus tropicalis

Alignment Length:	343	Identity:	87/343 - (25%)
Similarity:	149/343 - (43%)	Gaps:	55/343 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNF 146
            ||.|..::.::.|.|.|   ...:....|::|.||..|  .|::...| .:|...|::|:..|:.
Frog     5 VLTLIIMSAVKPLLCDR---CPRVCICDNIRTFVACTN--KNLTEVPT-SIPQYTQKLDLRGNDL 63

  Fly   147 SELPNWVGACASLTAINASHNRLNNVAVLLRNYRITE--------LVSLDLAYNDLKQLDQFP-E 202
            ..:||  ||..|:..:  :|..|....:    .||.|        ||.|:|..|.:..:.|.. :
Frog    64 KVIPN--GAFLSVPYL--THLSLQKCNI----ERIEEGALRGLGRLVYLNLGSNKISFIYQESFD 120

  Fly   203 GFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLN 267
            |.||::.|.|:.|.|..:....|... ..|..|::..|.|..||.........:..:.|:.|.:|
Frog   121 GLSSLQQLVLEKNRLEEIKPGAFGQL-GFLNFLHLGDNFLVYLPDMLFQGLQQVKWIRLSNNMIN 184

  Fly   268 ---DSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRV 329
               :..|..|.|   |:.|.|.:|.:..||...:.....|..|.|..|.:..:.||...:..|:.
Frog   185 VVSNEAFAALPN---LKRLSLDHNELQYLPTDALSRMSGLTRLELGWNPMTFISEEAVQMASLKQ 246

  Fly   330 LRCCNNLLL---------CTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQ 385
            | ..||:.:         .:|||:      ::|||:|.:..:.:||.:  .:|..|:|:|| .::
Frog   247 L-FLNNMAIQDLSFKAFERSPQLS------LIDLSNNQIRTIQVLAGL--EHLNRLNLTGN-AIR 301

  Fly   386 VDEQQFKVCQSQSQRHWS 403
            .|      |:.:|.:.|:
Frog   302 CD------CELRSFKQWA 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	17/59 (29%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	9/25 (36%)
		LRR_8	205..266	CDD:290566	15/60 (25%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	40/160 (25%)
		leucine-rich repeat	256..276	CDD:275380	5/22 (23%)
		LRR_8	279..359	CDD:290566	23/88 (26%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	13/52 (25%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085
chadl	XP_002934783.2	PPP1R42	37..232	CDD:411060	53/209 (25%)
		leucine-rich repeat	53..76	CDD:275380	8/24 (33%)
		leucine-rich repeat	77..100	CDD:275380	5/28 (18%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	5/23 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		leucine-rich repeat	221..243	CDD:275380	6/21 (29%)
		leucine-rich repeat	244..267	CDD:275380	4/23 (17%)
		leucine-rich repeat	268..287	CDD:275380	7/24 (29%)
		PCC	272..>346	CDD:188093	15/51 (29%)
		leucine-rich repeat	290..337	CDD:275380	9/31 (29%)
		inl_like_NEAT_1	<359..>647	CDD:411101
		leucine-rich repeat	399..422	CDD:275380
		LRR_8	422..481	CDD:404697
		leucine-rich repeat	423..446	CDD:275380
		leucine-rich repeat	447..470	CDD:275380
		leucine-rich repeat	471..494	CDD:275380
		leucine-rich repeat	495..518	CDD:275380
		leucine-rich repeat	519..542	CDD:275380
		leucine-rich repeat	543..566	CDD:275380
		leucine-rich repeat	567..591	CDD:275380
		leucine-rich repeat	592..615	CDD:275380
		leucine-rich repeat	617..639	CDD:275380
		leucine-rich repeat	640..651	CDD:275378
		LRRCT	647..693	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000