DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and lrrd1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_002934640.2 Gene:lrrd1 / 100490254 XenbaseID:XB-GENE-985410 Length:757 Species:Xenopus tropicalis


Alignment Length:888 Identity:202/888 - (22%)
Similarity:352/888 - (39%) Gaps:229/888 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLG------- 59
            |.:.|:..|..|: |..|.|::.|..:|             .|..|...::|...:|.       
 Frog     9 LTSARQVEDNLKN-LVPSDSNNMPRTVP-------------SGTGSITSINLNSKELTEIPPDVF 59

  Fly    60 -----GSILIGNYNYLTQL--EVCE-NEMEVLDLS------------SLAQLETLKCSRNKLMEL 104
                 ..:|:.| |::|.|  .:|. :::|:|.|.            ||:||..|..:.|::..|
 Frog    60 RCTNLQCLLLSN-NFMTHLPTSLCHLSKLEILSLEGNALVSLPPEICSLSQLTALNVNHNQIAVL 123

  Fly   105 --IING-TNLQTLVADHNYLHNIS------TTNTHPVPLKLQRIDISHNNFSELPNWVGACASLT 160
              .|:| .|::.|.|::|.|..:.      ||        ||.:.||.|:...||:...:..:|.
 Frog   124 PHEISGLKNIKQLFANNNKLSQLPPCLGDLTT--------LQVLCISGNSMKTLPDSTASLKNLH 180

  Fly   161 AINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFF 225
            .:|...|:::  |:....:|:::||.|.|:.|.:|.|.:......::|.|.|.||:|..||...:
 Frog   181 VLNLDGNQIS--ALPKAVFRLSQLVKLCLSGNQIKSLPKEIGDLKNLRELSLSSNQLTFLPVQLY 243

  Fly   226 AVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRI 290
            .:|  .||.|.:..|||:.:....||.....| ||:|.|.|.| |.|.:.....:..|.|..|::
 Frog   244 NLT--SLEELTLDDNKLTAISDKLQNLKQLKV-LSIANNLLTD-ITEKVCWCPAIECLKLNGNQM 304

  Fly   291 GVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTP-QLAKLAMLKVLDL 354
            ..||.. :.|...|:.|.:..|.|:.||:::|.|..|.|:.|.||.||..| :|.....:..|||
 Frog   305 YRLPTK-IHNLRNLKELHIERNALEMLPDQLAHLNNLSVIVCANNNLLWIPIELKNCNQITKLDL 368

  Fly   355 SHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTK 419
            |.|.|..|. .||....:|.||:|:.|   ::.|....:..::...|   :::|||         
 Frog   369 SGNKLSEVP-QALSSMTSLLYLNLNQN---EIHEIANSIIHNRKLEH---LELSGN--------- 417

  Fly   420 IRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQ 484
                                           ||:|:   :.::.|.....|     |:.......
 Frog   418 -------------------------------KLTVF---SVHFCGLHNLAY-----LDLSRNEIN 443

  Fly   485 EMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTR---APSKVRPLKSK 546
            .:...:.:|....:::..|  ..:.:|.:    :.| :::|.....|:..:   .||.:..|:..
 Frog   444 SVPSAISNLESLSELLLHS--NKFRRFPI----ELC-ALKSLQKIDLSGNQIETVPSGISLLEGL 501

  Fly   547 RYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKD--QIHSMPDPHVLELILSNDDEYLVVGNAQL 609
            |||  ..|......:.....|...|....:.|||  ::.|:||    ||             ::|
 Frog   502 RYV--NLSNNSFKVFPRELFSVSSLETLKISQKDGRKLISLPD----EL-------------SKL 547

  Fly   610 WSVMDIDRAAREIRKEENSLLAAKRLVDIA-------------QSFAAAESLSVIVVRFRHLGTD 661
            .::.:::.:...|:....|:...|.||.:.             .|.||.:.||:...:...|.:|
 Frog   548 KNLKELEISDNNIKTLPGSIGEMKNLVQLTATSNQLYHLPASISSLAALQQLSLKGNQLTSLPSD 612

  Fly   662 VDHL--IRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRD 724
            :..|  :||:........:|.||           .||               ..|..|.|   |.
 Frog   613 ISGLQKLREINLDSNPMLRPPSL-----------LCD---------------GKRLYPIG---RY 648

  Fly   725 LLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEE-QFKCWEYMLEQNTQLLFDKELNT 788
            |.:.|..||      ::||:..:|        :|.::.:|: .|.|.:..::       |:|:..
 Frog   649 LQSADLRDE------KILQKTFKL--------ISNNIPAEDFSFFCKKLRIK-------DEEVKG 692

  Fly   789 ISKSFTKQRTVPNAIMAATVL--PERN------DFTSNLMRTV 823
            |.|:.:.|  :|:.|:....:  .||:      |....|:|.:
 Frog   693 IVKNRSLQ--LPDKILQVLNMWKSERHPQTAPEDIAEQLIRVL 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 6/21 (29%)
LRR_8 109..169 CDD:290566 17/65 (26%)
leucine-rich repeat 111..135 CDD:275380 6/29 (21%)
leucine-rich repeat 136..158 CDD:275380 7/21 (33%)
leucine-rich repeat 159..183 CDD:275380 5/23 (22%)
leucine-rich repeat 184..209 CDD:275380 7/24 (29%)
LRR_8 205..266 CDD:290566 22/60 (37%)
leucine-rich repeat 210..230 CDD:275380 8/19 (42%)
leucine-rich repeat 232..255 CDD:275380 8/22 (36%)
LRR_RI <256..410 CDD:238064 49/154 (32%)
leucine-rich repeat 256..276 CDD:275380 9/19 (47%)
LRR_8 279..359 CDD:290566 28/80 (35%)
leucine-rich repeat 280..303 CDD:275380 6/22 (27%)
leucine-rich repeat 304..348 CDD:275380 17/44 (39%)
leucine-rich repeat 349..372 CDD:275380 9/22 (41%)
PP2Cc 461..655 CDD:294085 37/211 (18%)
lrrd1XP_002934640.2 PLN00113 41..>611 CDD:215061 155/666 (23%)
leucine-rich repeat 42..63 CDD:275380 2/20 (10%)
leucine-rich repeat 64..86 CDD:275380 6/22 (27%)
leucine-rich repeat 87..109 CDD:275380 5/21 (24%)
leucine-rich repeat 110..132 CDD:275380 6/21 (29%)
leucine-rich repeat 133..155 CDD:275380 4/21 (19%)
leucine-rich repeat 156..178 CDD:275380 7/21 (33%)
leucine-rich repeat 179..201 CDD:275380 5/23 (22%)
leucine-rich repeat 202..224 CDD:275380 7/21 (33%)
leucine-rich repeat 225..247 CDD:275380 9/23 (39%)
leucine-rich repeat 248..270 CDD:275380 8/21 (38%)
leucine-rich repeat 271..316 CDD:275380 15/47 (32%)
leucine-rich repeat 340..385 CDD:275380 18/45 (40%)
leucine-rich repeat 386..408 CDD:275380 6/24 (25%)
leucine-rich repeat 409..431 CDD:275380 8/67 (12%)
leucine-rich repeat 478..500 CDD:275380 4/21 (19%)
leucine-rich repeat 501..520 CDD:275380 4/20 (20%)
leucine-rich repeat 550..572 CDD:275380 2/21 (10%)
leucine-rich repeat 573..595 CDD:275380 3/21 (14%)
leucine-rich repeat 596..618 CDD:275380 5/21 (24%)
Death 664..744 CDD:260017 17/87 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.