DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and tlr3

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002934448.3	Gene:	tlr3 / 100486223	XenbaseID:	XB-GENE-491049	Length:	897	Species:	Xenopus tropicalis

Alignment Length:	502	Identity:	115/502 - (22%)
Similarity:	194/502 - (38%)	Gaps:	144/502 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YLTQLEVCENEMEVLDLSSLAQLET---LKCSRNKLMELIING----TNLQTLVADHNYLHNIS- 125
            :|::|.:..|.:..:|.:...:||.   |..|.||::...:..    .||:.|..:.|.:..::
Frog   122 HLSELHLASNGISNIDGNPFEKLENLLFLDMSHNKMISTALGNKQQLNNLKELYLNSNKISKLNK 186

  Fly   126 -----TTNTHPVPLKLQRIDISHNNFSEL-PNW---VGACASLTAINA--------------SHN 167
                 ..||     .||::|:|.|..:|: |..   :|:.|:|...|.              :|.
Frog   187 EAFEFLANT-----SLQKLDLSSNPLTEINPGCFQAIGSFAALVIQNTQLDPQRTEQVCSELAHT 246

  Fly   168 RLNNVAVLLRNYRI-------------TELVSLDLAYNDLKQLDQFPEGFSSIRSLQ---LQSNE 216
            .:.|:.  |.|.|:             |.|..|||:.|.|.|:|.  :.|.|:.:|:   |::|:
Frog   247 GVRNLT--LNNIRLSKIRNTTFKGLADTNLTVLDLSGNSLSQIDN--DSFVSLGALEILNLENND 307

  Fly   217 LPSL-PDNFFAVTHAR------------------------LETLNVSCNKLSTLPRYEQNNHAAL 256
            :..: |..|..::..|                        ::.||:..||:.::..:......:|
Frog   308 ISHVNPKTFNGLSKVRVLNLRKSLSSNLKLDDLSFQSLHNVQYLNMEANKIISITEHTFIGLTSL 372

  Fly   257 VNLSLAGN---------------------HLN--DSIFEPLHNAAKLRVLHLAYNRIGVLPAACV 298
            .||||:.:                     |||  .:....:.|.|.|.:.||....:|:
Frog   373 TNLSLSDSTLQQHTLTNRTFLSLSKSPLYHLNLTKTGLTKIENGAFLCLKHLQLLDMGL------ 431

  Fly   299 RNWPELEILVLSGNMLQQLPE-EVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRV 362
             |..:.|:   |||.|:.|.. |:..|...|.:...:|..:..|.|:||.:.|.. |:...|:
Frog   432 -NQIDQEV---SGNELEGLANIEMIYLSYNRRITLTSNSFIFAPSLSKLYLRKTA-LTFRDLN-- 489

  Fly   363 NLLALVPS-----RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAAL-----PT 417
                  ||     :||..||||.|....:.|..|     :|..:..::....||.|.|     |.
Frog   490 ------PSPFKVLQNLTVLDLSNNNIANIQEDVF-----ESLSNLRILSFEHNNLARLWKEANPG 543

  Fly   418 TKIRQVSAQRNQNKTSGPWTMGFAETPGS---GDCRKLSVYQLRAAN 461
            ..:..:...:|..|.| ..:.||.|.|.:   |.| ||.|..:...|
Frog   544 GPVLFLKGLKNLEKLS-LLSNGFDEIPANAFKGLC-KLKVLDIGENN 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/25 (24%)
		LRR_8	109..169	CDD:290566	18/83 (22%)
		leucine-rich repeat	111..135	CDD:275380	5/29 (17%)
		leucine-rich repeat	136..158	CDD:275380	8/25 (32%)
		leucine-rich repeat	159..183	CDD:275380	7/50 (14%)
		leucine-rich repeat	184..209	CDD:275380	10/24 (42%)
		LRR_8	205..266	CDD:290566	16/109 (15%)
		leucine-rich repeat	210..230	CDD:275380	5/23 (22%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	44/182 (24%)
		leucine-rich repeat	256..276	CDD:275380	8/42 (19%)
		LRR_8	279..359	CDD:290566	21/80 (26%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	14/44 (32%)
		leucine-rich repeat	349..372	CDD:275380	5/27 (19%)
		PP2Cc	461..655	CDD:294085	1/1 (100%)
tlr3	XP_002934448.3	PLN00113	26..>507	CDD:215061	93/412 (23%)
		leucine-rich repeat	54..74	CDD:275380
		leucine-rich repeat	75..98	CDD:275380
		leucine-rich repeat	99..122	CDD:275380	115/502 (23%)
		leucine-rich repeat	123..146	CDD:275380	5/22 (23%)
		leucine-rich repeat	147..170	CDD:275380	4/22 (18%)
		leucine-rich repeat	171..196	CDD:275380	5/29 (17%)
		leucine-rich repeat	197..230	CDD:275380	11/32 (34%)
		leucine-rich repeat	231..273	CDD:275380	5/43 (12%)
		leucine-rich repeat	274..297	CDD:275380	10/24 (42%)
		leucine-rich repeat	298..319	CDD:275380	5/20 (25%)
		leucine-rich repeat	322..347	CDD:275380	1/24 (4%)
		leucine-rich repeat	348..371	CDD:275380	4/22 (18%)
		leucine-rich repeat	424..448	CDD:275380	9/33 (27%)
		PPP1R42	446..637	CDD:411060	42/159 (26%)
		leucine-rich repeat	449..472	CDD:275380	4/22 (18%)
		leucine-rich repeat	473..498	CDD:275380	8/33 (24%)
		leucine-rich repeat	499..522	CDD:275380	9/27 (33%)
		leucine-rich repeat	523..554	CDD:275380	5/30 (17%)
		leucine-rich repeat	555..578	CDD:275380	8/24 (33%)
		leucine-rich repeat	579..602	CDD:275380	3/10 (30%)
		leucine-rich repeat	603..623	CDD:275380
		PCC	607..>689	CDD:188093
		Tlr3_TMD	691..720	CDD:407816
		TIR	746..890	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910