DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Lrriq4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_038959535.1	Gene:	Lrriq4 / 100363341	RGDID:	2323202	Length:	621	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	121/436 - (27%)
Similarity:	181/436 - (41%)	Gaps:	63/436 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IGNYNYLTQLEVCENEME--VLDLSSLAQLETLKCSRNKLM---ELIINGTNLQTLVADHNYLHN 123
            |.|...|.::.:.:|..|  ..||..|..||.:....|||.   |.|.:...||......|:|..
  Rat   222 IVNQTKLREIYLKQNHFENFPCDLCVLCNLEVIDLDDNKLKTIPEDIGHLVRLQKFYVASNHLMG 286

  Fly   124 ISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLD 188
            :..:.:|  ..||..:|::||:...||..:.....||.:..|.|||..|..||.|:     |||.
  Rat   287 LPESLSH--CRKLSVLDLTHNSIHSLPYSLEQLTELTEVGLSGNRLEKVPRLLCNW-----VSLH 344

  Fly   189 LAYNDLKQLDQFPEGFS---SIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQ 250
            |.|.....|......|.   ::|.|.|..|.:...|...  .|...||.|.:..||:..||
  Rat   345 LLYLRNTSLHGLRRSFKHLVNLRFLDLSQNHIDHFPVQI--CTLKDLEILALDDNKVKQLP---- 403

  Fly   251 NNHAALVNLSLAGNHLND--SIFEPLHNAAKLRVLHLAY---NRIGVLPAACVRNWPELEILVLS 310
            ...::|..|.:.|...||  |..|.:.:...|..|::..   :::..||.. ::....|:.|.:.
  Rat   404 PAISSLSKLKILGLTGNDFVSFPEEIFSLVSLEKLYIGQDQGSKLSSLPEN-IKKLTNLKELYIE 467

  Fly   311 GNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRV--NLLALVPSRN 372
            .|.|:|||..:..:..|.||.|.:|||...|. :.:...|:.|.|..|.|.|:  ||..||   |
  Rat   468 NNQLEQLPASLGLMPNLEVLDCRHNLLRQLPDAICQTRDLRELLLEDNLLSRLPENLDHLV---N 529

  Fly   373 LKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWT 437
            ||.|.|:.||   :::...:||:..::..|          ..|...:||:|.|.:.|     .|.
  Rat   530 LKVLTLTDNL---MEDPPMEVCEQGNEAIW----------RHLKENRIRKVMATKIQ-----AWW 576

  Fly   438 MGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAA 483
            .|.....|.|...:|    |:|...|.|...        :.:|:||
  Rat   577 RGIMVRKGYGSYEEL----LKARKKGKSPPK--------DKKGKAA 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	16/59 (27%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	10/23 (43%)
		leucine-rich repeat	184..209	CDD:275380	7/27 (26%)
		LRR_8	205..266	CDD:290566	16/63 (25%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	46/161 (29%)
		leucine-rich repeat	256..276	CDD:275380	7/21 (33%)
		LRR_8	279..359	CDD:290566	23/83 (28%)
		leucine-rich repeat	280..303	CDD:275380	4/25 (16%)
		leucine-rich repeat	304..348	CDD:275380	15/44 (34%)
		leucine-rich repeat	349..372	CDD:275380	10/24 (42%)
		PP2Cc	461..655	CDD:294085	5/23 (22%)
Lrriq4	XP_038959535.1	PLN00113	90..>494	CDD:215061	80/285 (28%)
		leucine-rich repeat	111..133	CDD:275380
		leucine-rich repeat	134..156	CDD:275380
		leucine-rich repeat	157..204	CDD:275380
		leucine-rich repeat	205..250	CDD:275380	8/27 (30%)
		leucine-rich repeat	251..273	CDD:275380	7/21 (33%)
		leucine-rich repeat	274..296	CDD:275380	5/23 (22%)
		leucine-rich repeat	297..319	CDD:275380	6/21 (29%)
		leucine-rich repeat	320..342	CDD:275380	10/26 (38%)
		leucine-rich repeat	343..365	CDD:275380	5/21 (24%)
		leucine-rich repeat	366..388	CDD:275380	6/23 (26%)
		leucine-rich repeat	389..411	CDD:275380	8/25 (32%)
		leucine-rich repeat	412..434	CDD:275380	6/21 (29%)
		leucine-rich repeat	435..460	CDD:275380	4/25 (16%)
		leucine-rich repeat	461..483	CDD:275380	7/21 (33%)
		leucine-rich repeat	484..506	CDD:275380	8/21 (38%)
		Adgb_C_mid-like	<530..>598	CDD:412094	22/89 (25%)
		IQ motif	570..595	CDD:412094	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910