DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and si:dkey-182i3.11

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_021322095.1	Gene:	si:dkey-182i3.11 / 100334238	ZFINID:	ZDB-GENE-121214-258	Length:	710	Species:	Danio rerio

Alignment Length:	429	Identity:	125/429 - (29%)
Similarity:	193/429 - (44%)	Gaps:	72/429 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QAATFGQTSPQKLSLKGSQ---LGGSILIGNYNYLTQLEVCENEMEVLDLS---SLAQLETLKCS 97
            |...:|..:.|.|:|..:|   |...:|.|.. .||.|::.:|.:::::::   :...|..|..|
Zfish   168 QMFLYGLINLQTLNLNINQILSLSYGVLEGPL-ALTDLQLRDNMIDMIEMNVFENCTYLAKLYLS 231

  Fly    98 RNKLMELIING-----TNLQTLVADHNYLHNIST----TNTHPVPLKLQRIDIS---HNNFSELP 150
            :||| :.:.||     |.|..|....|.|..|.|    ..::...|.||:.||:   .|.|||:
Zfish   232 KNKL-KSVGNGSFKGATGLNHLDLGLNGLAGIPTIVLQETSNLTSLYLQKNDITSIPDNVFSEI- 294

  Fly   151 NWVGACASLTAINASHNRLNNVAVLLRNYR-ITELVSLDLAYNDLKQLDQFP-EGFSSIRSLQLQ 213
                  .||..::.|:|.|  |::...::| :::||.|||::|.|:.|.|.. |....:.:|.|.
Zfish   295 ------LSLKHLDLSYNGL--VSISNGSFRSLSQLVYLDLSFNQLQTLTQHVFEDLGKLENLNLY 351

  Fly   214 SNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHL------------ 266
            .|:|.|||:|.|. ....|:.|.:..|.:|.:|....:..:||.:|.|..||:
Zfish   352 HNKLTSLPNNMFK-NLTMLKELQLDSNNISVIPPDLFHPLSALKDLQLDNNHISKLHSHTFKKLR 415

  Fly   267 ---------NDSIFEPLHNAAK-LRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEV 321
                     ||....|.|...| |:.|:|..|.|..:.....:|...|:.|.||.|.|.:|..|:
Zfish   416 QLKQLDISSNDLTKIPNHLFHKNLKELNLENNHISFISKFSFKNLHRLQSLKLSHNNLSKLYREL 480

  Fly   322 AT-LGQLRVLRCCNNLLLCTPQ--LAKLAMLKVLDLSHNHL-----DRVNLLALVPSRNLKYLDL 378
            .| |.:||.|....|.:...|.  ...|..|:|||||:|.:     |..|.|:.     ||.|||
Zfish   481 LTNLTRLRELLLNENQIETIPVGFFKGLENLRVLDLSNNKMHFILPDAFNDLSA-----LKDLDL 540

  Fly   379 SGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPT 417
            |.|....:.|..|     .|.|:.:.:.:..|....||:
Zfish   541 SFNFLHNLPEDIF-----ASLRNLTKLHLQNNKLRYLPS 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/23 (35%)
		LRR_8	109..169	CDD:290566	20/66 (30%)
		leucine-rich repeat	111..135	CDD:275380	6/27 (22%)
		leucine-rich repeat	136..158	CDD:275380	8/24 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	10/25 (40%)
		LRR_8	205..266	CDD:290566	19/60 (32%)
		leucine-rich repeat	210..230	CDD:275380	9/19 (47%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	53/183 (29%)
		leucine-rich repeat	256..276	CDD:275380	8/40 (20%)
		LRR_8	279..359	CDD:290566	30/83 (36%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	16/46 (35%)
		leucine-rich repeat	349..372	CDD:275380	10/27 (37%)
		PP2Cc	461..655	CDD:294085
si:dkey-182i3.11	XP_021322095.1	PLN00113	97..>617	CDD:331614	125/429 (29%)
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..176	CDD:275380	2/7 (29%)
		leucine-rich repeat	177..200	CDD:275380	7/23 (30%)
		leucine-rich repeat	201..224	CDD:275380	4/22 (18%)
		leucine-rich repeat	225..248	CDD:275380	8/23 (35%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	9/29 (31%)
		leucine-rich repeat	297..320	CDD:275380	6/24 (25%)
		leucine-rich repeat	321..344	CDD:275380	10/22 (45%)
		leucine-rich repeat	345..368	CDD:275380	9/23 (39%)
		leucine-rich repeat	369..392	CDD:275380	5/22 (23%)
		leucine-rich repeat	393..438	CDD:275380	9/44 (20%)
		leucine-rich repeat	417..436	CDD:275380	4/18 (22%)
		leucine-rich repeat	439..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..486	CDD:275380	10/22 (45%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	10/22 (45%)
		leucine-rich repeat	535..558	CDD:275380	10/27 (37%)
		leucine-rich repeat	559..582	CDD:275380	3/16 (19%)
		leucine-rich repeat	583..606	CDD:275380
		leucine-rich repeat	607..628	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910