DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and phlpp1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_009294739.3 Gene:phlpp1 / 100331906 ZFINID:ZDB-GENE-131127-271 Length:1483 Species:Danio rerio


Alignment Length:985 Identity:247/985 - (25%)
Similarity:400/985 - (40%) Gaps:215/985 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 TFGQTSPQKLSLKGSQLGGSILIGNYNYL---TQLEVCENEMEVLDLSSLAQLETLKCSRNKLME 103
            :|...:.:.:.|:.:|: .|:|.....:|   |||::.:|.::.||.|...:||.|.|.||::.:
Zfish   604 SFRLLTVRHVDLRLNQI-SSVLRDEPEFLRGVTQLDLRDNCLQELDASVFPRLEVLHCQRNRISQ 667

  Fly   104 LIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNR 168
            |.:.|..|:.|.|.:|.|..|..:   |....|..||||.|....||:|:.....|..::.|||:
Zfish   668 LRVCGAALKALHASNNELQEILVS---PAASNLTYIDISRNCMKALPDWLSDSRKLEVLDISHNQ 729

  Fly   169 LNNVAV-LLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARL 232
            :..:.. ||.:..:.::::   .:|.||:|.:..|. ..:..|.||.|:|..||.|.|..|.: |
Zfish   730 MTELPPWLLCSSSLRKILA---GHNQLKRLSERVER-PLVEVLDLQHNQLEELPCNLFLKTDS-L 789

  Fly   233 ETLNVSCNKLSTLP--RYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPA 295
            ..||||.|||.:||  ...:.:.:.|..|.|..|.|.|.....|.....||:||:|||::...||
Zfish   790 RCLNVSANKLESLPASSLSEESSSILQELYLTNNLLTDKCVPQLTGHTHLRILHMAYNQLQTFPA 854

  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRC---CNNLLLCTPQLAKLAMLKVLDLSHN 357
            :......:.....||| ||...   |.....:.|..|   |..:.:|   :.....::.:|||.|
Zfish   855 SHFVGKHQSFEFDLSGXMLMFC---VCVCVCVCVCVCVCVCVCVCVC---VCVCVCVQCVDLSCN 913

  Fly   358 HLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQ 422
            .|..:.|...:|.: |:.|||:|||:|.:|             |.:|..:  ||   :...:|..
Zfish   914 ELSDITLPETLPPK-LQELDLTGNLRLNLD-------------HKTLEQL--NN---IRCFRIDP 959

  Fly   423 VSAQRNQNKTSG---PWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQ 484
            ..:..:.|:.||   .|:.|:.|  .||...||.|..|...::.||.|||||:|:     |....
Zfish   960 PPSSFSANEASGGPAVWSHGYTE--ASGVKNKLCVAALSVNSFCGSREALYGVFD-----GDRNV 1017

  Fly   485 EMSHLVPDLMKQ---EQMVKDSAVRDYMKFTLLAAQQQCGSV-----RSAALFHLTRTRAPSKVR 541
            |:.:|:...|..   |::.:..:..|||..|.|..|::.|:.     .||.|.|:...  |:.  
Zfish  1018 EVPYLLQCTMNDILAEELHRTKSEEDYMTNTFLVMQRKLGTAGQKLGGSAVLCHIRHD--PTD-- 1078

  Fly   542 PLKSKRYVLRMASTGGLDAYLIR-----------------RTSQLRLTKPDVIQKDQIHS----- 584
              ....:.|..|:.|...|.|.|                 ..|::|..|..:.:.::::.     
Zfish  1079 --PGGCFTLTAANVGKCQAVLCRDGKALPLSLLHNISIPEEYSRIRQHKAIITEDNKVNGVTDST 1141

  Fly   585 ------------MPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVD 637
                        :|.|:|..|.|:..||:.::|:..|:..::...|...:||..::|.|||:|..
Zfish  1142 RIMGYSFLYPAVLPRPYVTTLPLTPRDEFFILGSRGLFEALEPSEAVEAVRKVPDALAAAKKLCT 1206

  Fly   638 IAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACR 702
            :|||:...:|||.:||:                             ||....|...||....|..
Zfish  1207 LAQSYGCTDSLSAVVVQ-----------------------------LSVAEDCCCCCCSTHTASA 1242

  Fly   703 HRAIEQEPLAGRS---------SPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVS 758
            ....:..|..|.|         .||..|:                  :..|....||..|..|.:
Zfish  1243 SIHPQPPPSPGPSLYPATSSGAPPSSCSE------------------ISSEVSASEMSSEVGSTA 1289

  Fly   759 ES----VLSEE----------QFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVL 809
            .|    :|.::          :.:|....|..||...|.::|:  |.:|:...: .|.:.:....
Zfish  1290 SSDEPPLLLQDAHLHLHPHPPRVQCCSLHLAPNTSGSFQRQLS--SATFSSALS-DNGLDSEDEE 1351

  Fly   810 PERNDFTSNLMRTVTNKFI-------STSTPQLPQ------PITTSVPLGSYHQVKQAPPGHFGS 861
            |....| ||..|......:       ..|||:||:      |...|..||...       |: ||
Zfish  1352 PIAGVF-SNGSRVEVEADVHCLGLLPPPSTPELPELDADKSPDAWSKTLGKRR-------GN-GS 1407

  Fly   862 ALSFQQAHSYGYNLFD-AKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAVTQERERNI 925
            ....:::|    ||.: |...|.      |:|.|    ||.:..:..|   :..|.:..|.|..:
Zfish  1408 VAPQERSH----NLIEVAADAPS------KKSGG----YFTAPAQPDP---DDQFIIPPELEEEV 1455

  Fly   926 LD-EEEHDDD 934
            .: .::|..|
Zfish  1456 KEIMKQHQQD 1465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 8/18 (44%)
LRR_8 109..169 CDD:290566 20/59 (34%)
leucine-rich repeat 111..135 CDD:275380 7/23 (30%)
leucine-rich repeat 136..158 CDD:275380 9/21 (43%)
leucine-rich repeat 159..183 CDD:275380 6/24 (25%)
leucine-rich repeat 184..209 CDD:275380 5/24 (21%)
LRR_8 205..266 CDD:290566 24/62 (39%)
leucine-rich repeat 210..230 CDD:275380 10/19 (53%)
leucine-rich repeat 232..255 CDD:275380 10/24 (42%)
LRR_RI <256..410 CDD:238064 44/156 (28%)
leucine-rich repeat 256..276 CDD:275380 7/19 (37%)
LRR_8 279..359 CDD:290566 23/82 (28%)
leucine-rich repeat 280..303 CDD:275380 9/22 (41%)
leucine-rich repeat 304..348 CDD:275380 10/46 (22%)
leucine-rich repeat 349..372 CDD:275380 7/22 (32%)
PP2Cc 461..655 CDD:294085 59/235 (25%)
phlpp1XP_009294739.3 PH-like 343..439 CDD:327399
LRR_8 446..505 CDD:316378
leucine-rich repeat 470..494 CDD:275380
LRR_8 493..551 CDD:316378
leucine-rich repeat 495..517 CDD:275380
leucine-rich repeat 518..540 CDD:275380
leucine-rich repeat 541..563 CDD:275380
leucine-rich repeat 564..586 CDD:275380
NEL 569..>860 CDD:330839 84/264 (32%)
leucine-rich repeat 587..608 CDD:275380 1/3 (33%)
leucine-rich repeat 610..633 CDD:275380 5/23 (22%)
leucine-rich repeat 634..674 CDD:275380 15/39 (38%)
leucine-rich repeat 675..696 CDD:275380 7/23 (30%)
leucine-rich repeat 697..719 CDD:275380 9/21 (43%)
leucine-rich repeat 720..742 CDD:275380 6/21 (29%)
leucine-rich repeat 743..764 CDD:275380 5/24 (21%)
leucine-rich repeat 766..788 CDD:275380 10/21 (48%)
leucine-rich repeat 789..812 CDD:275380 10/22 (45%)
leucine-rich repeat 815..838 CDD:275380 7/22 (32%)
leucine-rich repeat 839..859 CDD:275380 9/19 (47%)
PP2Cc 970..1222 CDD:214625 68/264 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172467at2759
OrthoFinder 1 1.000 - - FOG0003647
OrthoInspector 1 1.000 - - oto41212
orthoMCL 1 0.900 - - OOG6_102913
Panther 1 1.100 - - O PTHR45752
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.920

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