DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and chadlb

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001274009.1	Gene:	chadlb / 100330176	ZFINID:	ZDB-GENE-121205-5	Length:	765	Species:	Danio rerio

Alignment Length:	674	Identity:	156/674 - (23%)
Similarity:	233/674 - (34%)	Gaps:	170/674 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPVEVTAAEEEQAATFGQTS-PQKLSLKGSQLGGSILIGN------------------YNY---- 69
            |.::....||.|...|.|.. ...|||..:||   :.|.|                  .||
Zfish   131 LIIDRNRVEEIQPGAFSQLGFLNLLSLTHNQL---VYIPNMAFQGLQNIKWLRLSHNFINYLATE 192

  Fly    70 -------LTQLEVCENEMEVL---DLSSLAQLETLKCSRNK---LMELIINGTNLQTLVADHNYL 121
                   ||:|.:..||::..   .::.|:::..|:.|.|.   |.|..::...|..|:.|||.|
Zfish   193 AFAGLFTLTRLSLDNNELQFFPTETMTRLSEVTRLELSFNPMTYLGEESVSMLKLTHLLLDHNSL 257

  Fly   122 HNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVL--LRNYRITEL 184
            .:.|.......| :|..:|:|||....|.........||.:|.:.|.:.....|  ||.:...|.
Zfish   258 QDFSNAAILLSP-RLTHLDLSHNQLRILQPMAPGSPKLTRLNLAGNPIYCSCYLRPLREWATRER 321

  Fly   185 VSL--------DLAYNDLK------------------QLDQ------------------------ 199
            |.|        .|:..:|:                  :|::
Zfish   322 VRLGGTCGGPAHLSGENLEVVQPVNLRCLSQEAMLKAELEEQVLPALPTTPSPKKGKCPANCACE 386

  Fly   200 ---------------FPEGFS-SIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRY 248
                           .|.||| ..|.|.|:.|....:|.|.|..| |.:.:|::...|:..:...
Zfish   387 TENRHSSCENKGHTKIPRGFSPDTRLLDLRGNHFHYIPANSFPGT-AEVVSLHLQRCKIHDIEDG 450

  Fly   249 EQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNM 313
            ..:...:||.|.|:.|.|.....|.......|..|||..||....|....:..|.|..|.:..|.
Zfish   451 AFSGMKSLVYLYLSENDLTSLTPEAFKGLPHLTYLHLEKNRFTQFPKGAFKLLPGLLALHMENNA 515

  Fly   314 LQQLPEEVATLGQ-LRVLRCCNN-LLLCTPQLAKLAM-LKVLDLSHNHLDRVNLLALVPSRNLKY 375
            :.:|...:.|..: ||.|...:| :....||....|. |:.|.|..|.|..|...|...:|:|..
Zfish   516 IAKLETGLLTSAEKLRGLYLTSNAITAAAPQAFNPAPDLETLHLGSNKLQEVPTEAFSKARSLAE 580

  Fly   376 LDLSGNLQLQVDEQQFKVCQSQSQR----HWSLVDVSGNNRAALPTTKIRQVSAQRNQ------- 429
            |.||.|....:....|:...:..:.    |..|..||.:..|.| .:.:|.:..:.||
Zfish   581 LKLSHNPIRWIGAGAFQPVGTTLRHLYLDHMGLEKVSTDFLAGL-GSGLRSLLLEGNQLEELPDL 644

  Fly   430 NKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLM 494
            :..:|...:..||.|...||..|               .|....|.:..:.||.  ..| .|:|
Zfish   645 SPLTGLEVINLAENPLLCDCPLL---------------PLRKWIEQVNLKVRAT--CGH-PPEL- 690

  Fly   495 KQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAP----SKVRPLKSKRYVLRMAST 555
             :.|.|||..|           .:.|...:|.:..|...||||    ::|.|.|..:.|.|.| |
Zfish   691 -RGQRVKDVHV-----------FKSCPGGKSPSAQHPKPTRAPKPESARVSPPKIIKRVDRKA-T 742

  Fly   556 GGLDAYLIRRTSQLRLTKPDVIQK 579
            |          ...:..||..:||
Zfish   743 G----------KSRKGAKPHTVQK 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/21 (24%)
		LRR_8	109..169	CDD:290566	18/59 (31%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	7/25 (28%)
		leucine-rich repeat	184..209	CDD:275380	9/90 (10%)
		LRR_8	205..266	CDD:290566	17/61 (28%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	2/22 (9%)
		LRR_RI	<256..410	CDD:238064	45/160 (28%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	24/82 (29%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	11/45 (24%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	31/123 (25%)
chadlb	NP_001274009.1	leucine-rich repeat	58..79	CDD:275380
		LRR_RI	59..307	CDD:238064	44/179 (25%)
		LRR_8	78..138	CDD:290566	1/6 (17%)
		leucine-rich repeat	80..103	CDD:275380
		leucine-rich repeat	104..127	CDD:275380
		LRR_8	126..184	CDD:290566	13/55 (24%)
		leucine-rich repeat	128..151	CDD:275380	6/19 (32%)
		leucine-rich repeat	152..175	CDD:275380	7/25 (28%)
		LRR_8	175..234	CDD:290566	11/58 (19%)
		leucine-rich repeat	176..199	CDD:275380	2/22 (9%)
		leucine-rich repeat	200..223	CDD:275380	6/22 (27%)
		leucine-rich repeat	224..246	CDD:275380	5/21 (24%)
		LRR_8	246..304	CDD:290566	18/58 (31%)
		leucine-rich repeat	247..270	CDD:275380	8/23 (35%)
		TPKR_C2	302..342	CDD:301599	9/39 (23%)
		LRR_RI	408..609	CDD:238064	52/201 (26%)
		leucine-rich repeat	410..433	CDD:275380	8/23 (35%)
		leucine-rich repeat	434..457	CDD:275380	2/22 (9%)
		LRR_8	436..492	CDD:290566	14/55 (25%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		LRR_8	480..540	CDD:290566	17/59 (29%)
		leucine-rich repeat	482..505	CDD:275380	7/22 (32%)
		leucine-rich repeat	506..529	CDD:275380	5/22 (23%)
		LRR_8	529..588	CDD:290566	20/58 (34%)
		leucine-rich repeat	530..553	CDD:275380	7/22 (32%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		leucine-rich repeat	578..602	CDD:275380	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000