DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and lrrc4c

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002938986.1	Gene:	lrrc4c / 100188921	XenbaseID:	XB-GENE-5772259	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	323	Identity:	79/323 - (24%)
Similarity:	135/323 - (41%)	Gaps:	90/323 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 QLEVCENEMEVLDLSS---LAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            ||.:.||:::::.:.|   |..||.|:.|||.:..:.|..         .|.|.|::|
Frog    80 QLNLHENQIQIIKVDSFKHLRHLEVLQLSRNHIRTIEIGA---------FNGLANLNT------- 128

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNY---RITELVSLDLAYNDLK 195
                 :::..|..:.:||  ||...|:.:.....| ||....:.:|   ||..|..|||  .::|
Frog   129 -----LELFDNRLTTIPN--GAFEYLSKLKELWLR-NNPIESIPSYAFNRIPSLRRLDL--GEMK 183

  Fly   196 QLDQFP----EGFSSIRSLQL---QSNELPSL--------------------PDNFFAVTHARLE 233
            :|....    ||.|:::.|.|   ...::|:|                    |.:|..:||  |:
Frog   184 RLSYISEGAFEGLSNLKYLNLGMCNLRDIPNLTPLVKLDELDLSGNHLSVLRPGSFQGLTH--LQ 246

  Fly   234 TLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLN---DSIFEPLHNAAKLRVLHLAYNRIGVLPA 295
            .|.:..:::..:.|...::..:||.|:||.|:|.   ..:|.||||..::::.|..:|
Frog   247 KLWIMHSQIQVIERNAFDDLQSLVELNLAHNNLTLLPHDLFTPLHNLQRIQLHHNPWN------- 304

  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNH 358
             |     ..:||.||..:     :|:.|.|.....||      .||  ..|....:.:|.||:
Frog   305 -C-----NCDILWLSWWL-----KEIVTTGSTCCARC------STP--PSLKGTHIAELDHNY 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/18 (39%)
		LRR_8	109..169	CDD:290566	10/59 (17%)
		leucine-rich repeat	111..135	CDD:275380	4/23 (17%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	7/26 (27%)
		leucine-rich repeat	184..209	CDD:275380	9/28 (32%)
		LRR_8	205..266	CDD:290566	18/83 (22%)
		leucine-rich repeat	210..230	CDD:275380	7/42 (17%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	30/106 (28%)
		leucine-rich repeat	256..276	CDD:275380	10/22 (45%)
		LRR_8	279..359	CDD:290566	18/80 (23%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	3/10 (30%)
		PP2Cc	461..655	CDD:294085
lrrc4c	XP_002938986.1	LRRNT	47..78	CDD:214470
		LRR	<77..302	CDD:227223	62/249 (25%)
		leucine-rich repeat	78..101	CDD:275380	6/20 (30%)
		leucine-rich repeat	102..125	CDD:275380	9/31 (29%)
		leucine-rich repeat	126..149	CDD:275380	7/36 (19%)
		leucine-rich repeat	150..173	CDD:275380	6/23 (26%)
		leucine-rich repeat	174..198	CDD:275380	8/25 (32%)
		leucine-rich repeat	199..220	CDD:275380	4/20 (20%)
		leucine-rich repeat	221..244	CDD:275380	2/22 (9%)
		leucine-rich repeat	245..268	CDD:275380	3/22 (14%)
		leucine-rich repeat	269..290	CDD:275380	8/20 (40%)
		LRRCT	301..351	CDD:214507	17/74 (23%)
		Ig	354..443	CDD:416386
		Ig strand A	354..357	CDD:409353
		Ig strand A'	361..364	CDD:409353
		Ig strand B	370..377	CDD:409353
		Ig strand C	383..388	CDD:409353
		Ig strand C'	391..393	CDD:409353
		Ig strand D	402..406	CDD:409353
		Ig strand E	409..413	CDD:409353
		Ig strand F	423..430	CDD:409353
		Ig strand G	433..443	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000