DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and XB964897

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001123809.1	Gene:	XB964897 / 100170560	XenbaseID:	XB-GENE-964898	Length:	798	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	112/491 - (22%)
Similarity:	186/491 - (37%)	Gaps:	144/491 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EVCENEMEVLDLSS-------LAQLETLKCSRNKLMELIING--------TNLQTL--------- 114
            |..||:::.|:|::       ..:|:|...:|.:|..|.:.|        |.||:|
Frog   386 EASENKLKQLNLNNEWTVEKLRLKLQTNASNRLELHLLKLPGLPDTVFEITELQSLKLESIPNVM 450

  Fly   115 ----VADHNYLHNIS----------------TTNTHPVPLKLQRIDISHNNFSELPNWVGACASL 159
                :|..|.|..:|                ..|.|.:.:|.  :...|     :|.|:....||
Frog   451 IPAAIAQLNNLQELSLWTCPAKIHSAALAFLKENVHSLSVKF--VGSPH-----IPQWMCDLGSL 508

  Fly   160 TAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNF 224
            ..:|.:......::....||...:|                    .|::.|.:.|| |.|:|.
Frog   509 EELNLTGLFTPEISKHFPNYSFKKL--------------------KSLKHLVINSN-LTSIPQ-- 550

  Fly   225 FAV-THARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYN 288
            :|| ..|:|:.|::..|::..:.|....|.|.|:.|.|....| |.|...:.:...|:.|.|..|
Frog   551 YAVDISAQLQKLSIDNNEIKLVTRNSLKNMANLMTLELVNCKL-DQIPNSIFSLLALKELDLKNN 614

  Fly   289 RI-GVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNN--------LLLCTPQLA 344
            .: .:...|..:|..:|.||.|..|.:.::|:.::.|..|..|...:|        |.||
Frog   615 NLKSIQEIASFQNLQKLSILKLWHNSITKIPDHISKLANLEQLYISHNNIGDLPHDLFLC----- 674

  Fly   345 KLAMLKVLDLSHNHLDRV-----NLLALVPSRNLKYLDLSGN-LQLQVDEQQFKVCQSQSQRHWS 403
              ..|:.|:||:|::..:     ||      .||||..:|.| ::...||..|  ||.
Frog   675 --CKLRHLELSNNNIRSIPHIIRNL------SNLKYFSVSYNRIETIPDELYF--CQK------- 722

  Fly   404 LVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEA 468
                       |.|..:|    ..|.|..|          |..|:..:||...:: .|..||...
Frog   723 -----------LETLNLR----HNNINTLS----------PNIGNLAQLSCLDVK-ENPIGSLPL 761

  Fly   469 LYGMFEALEGRGRAAQE-MSHLVP----DLMKQEQM 499
            ..|..:||:..|.:.:: :...:|    |.|.:||:
Frog   762 ELGSCQALKRNGLSVEDRLFETLPFDIRDKMTKEQI 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/26 (23%)
		LRR_8	109..169	CDD:290566	17/88 (19%)
		leucine-rich repeat	111..135	CDD:275380	9/52 (17%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	2/24 (8%)
		LRR_8	205..266	CDD:290566	19/61 (31%)
		leucine-rich repeat	210..230	CDD:275380	8/20 (40%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	43/168 (26%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	24/88 (27%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	13/51 (25%)
		leucine-rich repeat	349..372	CDD:275380	7/27 (26%)
		PP2Cc	461..655	CDD:294085	12/44 (27%)
XB964897	NP_001123809.1	leucine-rich repeat	606..630	CDD:275380	6/23 (26%)
		leucine-rich repeat	631..653	CDD:275380	7/21 (33%)
		leucine-rich repeat	654..676	CDD:275380	6/28 (21%)
		LRR_8	676..733	CDD:290566	21/86 (24%)
		leucine-rich repeat	677..699	CDD:275380	7/27 (26%)
		leucine-rich repeat	700..722	CDD:275380	9/23 (39%)
		leucine-rich repeat	723..745	CDD:275380	8/35 (23%)
		leucine-rich repeat	746..766	CDD:275380	6/20 (30%)
		Pannexin_like	1..330	CDD:289311
		leucine-rich repeat	392..437	CDD:275380	8/44 (18%)
		leucine-rich repeat	488..504	CDD:275380	4/22 (18%)
		LRR_RI	534..767	CDD:238064	73/284 (26%)
		leucine-rich repeat	536..558	CDD:275380	8/24 (33%)
		LRR_8	558..616	CDD:290566	16/58 (28%)
		leucine-rich repeat	559..582	CDD:275380	5/22 (23%)
		leucine-rich repeat	583..605	CDD:275380	6/22 (27%)
		LRR_8	606..664	CDD:290566	16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010