DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrig3

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002940426.3	Gene:	lrig3 / 100151727	XenbaseID:	XB-GENE-1219309	Length:	1109	Species:	Xenopus tropicalis

Alignment Length:	1089	Identity:	214/1089 - (19%)
Similarity:	373/1089 - (34%)	Gaps:	334/1089 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GPHPLPV----EVTAAEEEQAATFGQTSPQ---KLSLKGSQLGGSILIGNYNY---LTQLEVCEN 78
            ||.|.|.    ::......:.|......|:   :|.|..::| .||...:.|:   |.:|.:..|
Frog    39 GPCPSPCRCLGDLLDCSRRKLAVVPANLPEWVVQLDLSHNKL-SSINPSSMNHLHNLRELRLNNN 102

  Fly    79 EMEVL-DLSSLAQLETLKCSRNKLMELIING-----TNLQTLVADHNYLHNISTTNTHPVPLKLQ 137
            |:::: ||..|:...||....|..:|:|:..     .:|:||...:|.:..: ...:.|. |:|:
Frog   103 ELQIVPDLGPLSANITLFSLTNNKIEVILPEHLKPYQSLETLDLSNNLITEL-RAGSFPT-LQLK 165

  Fly   138 RIDISHNNFSELPNWVGA----CASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQ-L 197
            .:.|::|..|.:.:  ||    .|:|..:..:.||::.:.  .:.::::.|..|:|..|.:|: |
Frog   166 YLYINNNRISTMQS--GAFDNLSATLQVLKLNKNRISYIP--SKMFKLSNLQHLELNRNRIKEIL 226

  Fly   198 DQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLA 262
            ....:|..|::||::|.|.:..|.|..|    ..|.|:.:                     |.|.
Frog   227 GLTFQGLDSLKSLRIQRNLITRLMDGAF----WGLSTMEI---------------------LQLD 266

  Fly   263 GNHLNDSIFEPLHNAAKLRVLHLAYNRI-GVLPAACVRNW---PELEILVLSGNMLQQLPE-EVA 322
            .|.|.:.....|:....|:.|||:.|.| .:.|.|    |   .:|..|.|:.|.|.:|.| ..|
Frog   267 HNRLTEITKGWLYGLLMLQKLHLSQNAISSITPDA----WEFCQKLSELDLAFNQLTRLEESSFA 327

  Fly   323 TLGQLRVLRCCNNLL--LCTPQLAKLAMLKVLDLSHNH--------------LDRVNLLALVPSR 371
            .||.|..|...||.:  :.......|:.|..|||..|.              |:|:..|.|..:|
Frog   328 GLGLLGGLYIGNNKINFIADGAFRGLSSLNSLDLKSNEISWTIEDMNGTFSGLERLKRLILQDNR 392

  Fly   372 -------------NLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQV 423
                         .|:|||||.|....:....|...:|..|.:.:...:..:.:.......:.:.
Frog   393 ITSITKKAFSWLDALEYLDLSDNAITSMQTNAFSQMKSLQQLYLNTTSLLCDCQLKWLPKWLAES 457

  Fly   424 SAQRNQNKTSG-PWTMG----FAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGR---- 479
            ..|...|.:.| |..:.    ||.:|....|......|:.......|         |::|.
Frog   458 KFQTFVNASCGHPQILKGKSIFAVSPDDFVCDDFPKPQITVQPETQS---------AIKGSNVTF 513

  Fly   480 --GRAAQEMSHLVPDLMKQEQMVKDSAVRDY----------MKFTLL----------AAQQQCGS 522
              ..|:...|.:.....|..:::.||.:.:|          |::|.:          ..:.||..
Frog   514 ICSAASSSESPMTFAWKKDNELLHDSEIENYAHLRAQGGEVMEYTTILRLRNVEFINEGKYQCVI 578

  Fly   523 VRSAALFHLTRTRAPSKVRPLKSKR---YVLRMASTGGLDAYLI-RRTSQLRLTKP-----DVIQ 578
            .......:..:.:....:.||.:|.   ..:|..||..|:...: ..|.|:...|.     ...:
Frog   579 SNHFGPTYSVKAKLTVNMLPLFTKMPMDLTIRAGSTARLECAAVGHPTPQIAWQKNGGTDFPAAR 643

  Fly   579 KDQIHSMPDPHVLELILSNDDEYLVV----------------------GNAQLWSVMD------- 614
            :.::|.||:          ||.:.:|                      .||.| :|::
Frog   644 ERRMHVMPE----------DDVFFIVNVKTEDIGVYSCTAQNSAGSISANATL-TVLETPSFLRP 697

  Fly   615 -IDRAAREIRKEENSLLAA----------------KRLVDIAQSFAAAESLSVIVVRFRHLGTDV 662
             :||.|   .|.|.::|..                ..||...:.|.||.:..:|:|     .||:
Frog   698 LVDRTA---SKGETTVLQCIAGGSPTPKVNWTKDDSPLVVTERHFFAAGNQHLIIV-----DTDL 754

  Fly   663 DHLIRELKQSVRKKPQPVSLPLSSGSVCKRTC-------CDRSNACRHRAIEQEPLAGRSSPSGQ 720
            :                     .:|   |.||       .:|.|.  |       |:...:|:..
Frog   755 E---------------------DAG---KYTCEVSNILGTERGNI--H-------LSVLPNPTCD 786

  Fly   721 SDRDLLAKDKDDEF-----------------------VLAHARVLQEEQQLEMLDETE------- 755
            |..:.:...:||.:                       ::.|.|...|:..:...|||.
Frog   787 SPVNTIQTAEDDGWATAGIVIIAVVCCVVGTSLVWVVIIYHTRRKNEDCSVTNTDETNLPVDTPS 851

  Fly   756 -SVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNL 819
             ..|:..|:|.|.   .|...:|....|      |:.|           |:...|.:|::...:|
Frog   852 YLSSQGTLAERQD---GYGSSENGSHQF------ITSS-----------MSGYFLQQRDNGACHL 896

  Fly   820 MRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKF 884
                      .:..:....:.|...|.:|..|    ||..     :.:.::|..:.::.     |
Frog   897 ----------DNGSEADMEVATDPLLFNYTGV----PGSL-----YLRGNTYDPDAYEI-----F 937

  Fly   885 HGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAVTQERERNILDEEEHDD 933
            |.|.......||...:.|     .|..:.||.         |...:|||
Frog   938 HAGYGMDRRTPNMNLYES-----EYLKQKDFG---------LYGHQHDD 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/23 (22%)
		LRR_8	109..169	CDD:290566	15/63 (24%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	6/25 (24%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	8/25 (32%)
		LRR_8	205..266	CDD:290566	13/60 (22%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	2/22 (9%)
		LRR_RI	<256..410	CDD:238064	49/187 (26%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	29/100 (29%)
		leucine-rich repeat	280..303	CDD:275380	9/26 (35%)
		leucine-rich repeat	304..348	CDD:275380	15/46 (33%)
		leucine-rich repeat	349..372	CDD:275380	10/49 (20%)
		PP2Cc	461..655	CDD:294085	46/274 (17%)
lrig3	XP_002940426.3	LRRNT	40..67	CDD:214470	4/26 (15%)
		leucine-rich repeat	52..69	CDD:275380	2/16 (13%)
		LRR	<58..>243	CDD:227223	46/191 (24%)
		internalin_A	70..>437	CDD:380193	100/402 (25%)
		leucine-rich repeat	73..93	CDD:275380	6/20 (30%)
		leucine-rich repeat	94..140	CDD:275380	12/45 (27%)
		leucine-rich repeat	141..163	CDD:275380	5/23 (22%)
		leucine-rich repeat	164..187	CDD:275380	6/24 (25%)
		leucine-rich repeat	189..211	CDD:275380	3/23 (13%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	8/26 (31%)
		leucine-rich repeat	260..283	CDD:275380	5/43 (12%)
		leucine-rich repeat	284..307	CDD:275380	9/26 (35%)
		leucine-rich repeat	308..331	CDD:275380	9/22 (41%)
		leucine-rich repeat	332..355	CDD:275380	5/22 (23%)
		leucine-rich repeat	356..380	CDD:275380	5/23 (22%)
		leucine-rich repeat	383..406	CDD:275380	3/22 (14%)
		leucine-rich repeat	407..428	CDD:275380	8/20 (40%)
		PCC	411..>489	CDD:188093	14/77 (18%)
		Ig_3	493..580	CDD:404760	14/95 (15%)
		Ig strand A	494..497	CDD:409353	1/2 (50%)
		Ig strand A'	500..505	CDD:409353	1/13 (8%)
		Ig strand B	511..519	CDD:409353	0/7 (0%)
		Ig strand C	526..531	CDD:409353	0/4 (0%)
		Ig strand C'	533..535	CDD:409353	0/1 (0%)
		Ig strand D	552..555	CDD:409353	0/2 (0%)
		Ig strand E	559..565	CDD:409353	0/5 (0%)
		Ig strand F	572..579	CDD:409353	2/6 (33%)
		Ig strand G	586..594	CDD:409353	0/7 (0%)
		IgI_LRIG1-like	600..689	CDD:409420	17/99 (17%)
		Ig strand B	615..619	CDD:409420	1/3 (33%)
		Ig strand C	628..632	CDD:409420	1/3 (33%)
		Ig strand E	654..658	CDD:409420	1/3 (33%)
		Ig strand F	668..673	CDD:409420	0/4 (0%)
		Ig strand G	681..684	CDD:409420	0/2 (0%)
		I-set	692..779	CDD:400151	23/127 (18%)
		Ig strand A	693..695	CDD:409353	0/1 (0%)
		Ig strand A'	700..704	CDD:409353	3/6 (50%)
		Ig strand B	707..714	CDD:409353	2/6 (33%)
		Ig strand C	721..727	CDD:409353	0/5 (0%)
		Ig strand C'	728..730	CDD:409353	0/1 (0%)
		Ig strand D	737..740	CDD:409353	0/2 (0%)
		Ig strand E	743..751	CDD:409353	2/12 (17%)
		Ig strand F	758..766	CDD:409353	4/10 (40%)
		Ig strand G	770..779	CDD:409353	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910