DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrfn4b

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_021333806.1	Gene:	lrfn4b / 100149980	ZFINID:	ZDB-GENE-070705-473	Length:	1131	Species:	Danio rerio

Alignment Length:	735	Identity:	131/735 - (17%)
Similarity:	221/735 - (30%)	Gaps:	303/735 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 DHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRI 181
            |:..|:.|:..|.:|:||.....        ||.........|...||.|        |:|
Zfish   281 DYRGLNKITIRNRYPLPLMATAF--------ELLQGASIFTKLDLRNAYH--------LVR---- 325

  Fly   182 TELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP 246
                        ::|.|::...|::    .....|...:|   |.:|:|               |
Zfish   326 ------------IRQGDEWKTAFNT----PTGHYEYLVMP---FGLTNA---------------P 356

  Fly   247 RYEQNNHAALVNLSLAGNHLNDSIFEPL------------HNAAKLRVL-HLAYNRIGVLPAAC- 297
            ...|    ||:| .:..:.||..:|..|            |.....||| .|..|.:.|.|..|
Zfish   357 AVFQ----ALIN-DVLRDMLNIFVFVYLDDILIFSKSMEEHEGHVSRVLQRLLENHLFVKPEKCE 416

  Fly   298 ---------------------------VRNWP------ELEILVLSGNMLQQLPEEVATLGQLRV 329
                                       |.|||      |::..|...|..:            :.
Zfish   417 FHVSLTKFLGYIVTPGHLEMDPSKIKAVLNWPIPTTVKEVQRFVGFANFYR------------KF 469

  Fly   330 LRCCNNLLLCTPQLAKLAMLKV----------LDLSHNHLDRVNLLAL--VPSRNLKYLDLSGNL 382
            :|..::::.....|.|...:|:          .||.    ||.....:  :|:.::.::
Zfish   470 IRNFSSVVAPLTALTKGGGVKIEWGPKAAAAFQDLK----DRFTSAPILSIPNPDIPFM------ 524

  Fly   383 QLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSG 447
             ::||..                ||.           :..:.:|||::....|
Zfish   525 -VEVDAS----------------DVG-----------VGAILSQRNEDGKLHP------------ 549

  Fly   448 DC----RKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDY 508
             |    |:||..:   .||...|..|..:..|||       |..|.:.......|::.|....:|
Zfish   550 -CAFMSRRLSNAE---RNYHVGDRELLAVKLALE-------EWRHWLEGARHPFQVLTDHKNLEY 603

  Fly   509 MKFTLLAAQQQCGSVRSAALFH-------------------LTRTRAP-SKVRPLKSKRYVLRMA 553
            ::   .|.|......|.:..|:                   |:|..:| :..:|:.|   ::..:
Zfish   604 LQ---QAKQLNPRQARWSLFFNRFQFILTYRPGSKNLKPDALSRAYSPETHEKPVSS---IIPSS 662

  Fly   554 STGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRA 618
                      |..:.||.....|::|.|... |||                ||..| ..:.:.||
Zfish   663 ----------RIVAPLRWDLEQVVRKAQTKE-PDP----------------GNGPL-GALYVPRA 699

  Fly   619 ARE--IRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRF--RHLGTDVDHLIRELK-----QSVR 674
            .|.  ::....|:|....        .::.:|..:..||  ..:..||...:...:     :|..
Zfish   700 VRAQVLQWGHESVLTCHP--------GSSRTLEFLRRRFWWPSIKEDVKGYVEACQVCCQGKSSH 756

  Fly   675 KKPQ------PV--------------SLPLSSGSVCKRTCCDR-SNACRHRAIEQEPLAGRSSPS 718
            ::||      ||              .||||.|:.......|| |.|.|...:.:.|.|..::
Zfish   757 QRPQGLLHPLPVPHRPWSHLSLDFITGLPLSQGNTVILVVVDRFSKAARFIPLPKLPSAKETA-- 819

  Fly   719 GQSDRDLLAKDKDDEFVLAH 738
                          |.:::|
Zfish   820 --------------ELIISH 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	13/51 (25%)
		leucine-rich repeat	111..135	CDD:275380	6/17 (35%)
		leucine-rich repeat	136..158	CDD:275380	2/21 (10%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	10/60 (17%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	2/22 (9%)
		LRR_RI	<256..410	CDD:238064	35/212 (17%)
		leucine-rich repeat	256..276	CDD:275380	6/31 (19%)
		LRR_8	279..359	CDD:290566	21/124 (17%)
		leucine-rich repeat	280..303	CDD:275380	12/57 (21%)
		leucine-rich repeat	304..348	CDD:275380	5/43 (12%)
		leucine-rich repeat	349..372	CDD:275380	6/34 (18%)
		PP2Cc	461..655	CDD:294085	39/215 (18%)
lrfn4b	XP_021333806.1	retropepsin_like	58..144	CDD:133136
		RT_LTR	253..429	CDD:238825	41/206 (20%)
		RNase_HI_RT_Ty3	525..646	CDD:260006	30/173 (17%)
		zf-H2C2	716..749	CDD:324145	5/40 (13%)
		rve	772..885	CDD:307008	14/70 (20%)
		Chromo	1069..1116	CDD:306815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000