DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and LRRC70

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_852607.3	Gene:	LRRC70 / 100130733	HGNCID:	35155	Length:	622	Species:	Homo sapiens

Alignment Length:	369	Identity:	99/369 - (26%)
Similarity:	161/369 - (43%)	Gaps:	48/369 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNN 145
            |:|..||:.||    |:..:     ||..||.......|:..:       .|.|.|...:||:.|
Human    28 EILGCSSVCQL----CTGRQ-----INCRNLGLSSIPKNFPES-------TVFLYLTGNNISYIN 76

  Fly   146 FSELPNWVGACASLTAINASHNRLNNV----AVLLRNYRITELVSLDLAYNDLKQLDQFP---EG 203
            .|||.    ...||.|:...::.:..|    .|.||:     |..|.|..|.:|:||  |   :|
Human    77 ESELT----GLHSLVALYLDNSNILYVYPKAFVQLRH-----LYFLFLNNNFIKRLD--PGIFKG 130

  Fly   204 FSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNH--- 265
            ..::|:|.||.|::..:|...|. ....::.||:..|:|:.|.........||..|.|:.|:
Human   131 LLNLRNLYLQYNQVSFVPRGVFN-DLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR 194

  Fly   266 LNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQL-PEEVATLGQLRV 329
            :::|.|:.|.|   |..|:|..|.:..:|:........|..|.||.|.::.: |.....|..|..
Human   195 ISESGFQHLEN---LACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEY 256

  Fly   330 LRCCNNLL--LCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFK 392
            |...|:.:  :.....:.:..||.|.||||.|:.:|.......:||.||.|..|..:.:|...|:
Human   257 LLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFE 321

  Fly   393 VCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPW 436
            ...:..:    ::::|.||..||....::.:|:..:....|.||
Human   322 NMGASLK----ILNLSFNNLTALHPRVLKPLSSLIHLQANSNPW 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	15/59 (25%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/27 (22%)
		leucine-rich repeat	184..209	CDD:275380	9/27 (33%)
		LRR_8	205..266	CDD:290566	17/63 (27%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	41/159 (26%)
		leucine-rich repeat	256..276	CDD:275380	7/22 (32%)
		LRR_8	279..359	CDD:290566	22/82 (27%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	10/46 (22%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085
LRRC70	NP_852607.3	LRRNT	31..62	CDD:214470	10/46 (22%)
		LRR 1	61..82		9/31 (29%)
		leucine-rich repeat	65..85	CDD:275380	8/23 (35%)
		LRR_8	85..144	CDD:290566	21/65 (32%)
		LRR 2	85..106		4/20 (20%)
		leucine-rich repeat	86..109	CDD:275380	5/22 (23%)
		LRR 3	109..130		8/27 (30%)
		leucine-rich repeat	110..133	CDD:275380	9/24 (38%)
		LRR_8	133..192	CDD:290566	17/59 (29%)
		LRR 4	133..154		7/21 (33%)
		leucine-rich repeat	134..157	CDD:275380	7/23 (30%)
		LRR 5	157..178		5/20 (25%)
		leucine-rich repeat	158..181	CDD:275380	5/22 (23%)
		LRR_RI	<159..340	CDD:238064	49/187 (26%)
		LRR 6	181..202		7/20 (35%)
		LRR_8	182..240	CDD:290566	18/60 (30%)
		leucine-rich repeat	182..205	CDD:275380	7/22 (32%)
		LRR 7	205..226		6/23 (26%)
		leucine-rich repeat	206..229	CDD:275380	5/22 (23%)
		LRR_8	228..288	CDD:290566	17/59 (29%)
		LRR 8	229..250		6/20 (30%)
		leucine-rich repeat	230..253	CDD:275380	7/22 (32%)
		LRR 9	253..274		3/20 (15%)
		leucine-rich repeat	254..277	CDD:275380	3/22 (14%)
		LRR_8	277..337	CDD:290566	19/63 (30%)
		LRR 10	277..298		9/20 (45%)
		leucine-rich repeat	278..301	CDD:275380	9/22 (41%)
		LRR 11	301..322		8/20 (40%)
		leucine-rich repeat	302..326	CDD:275380	7/23 (30%)
		LRR 12	326..347		5/24 (21%)
		leucine-rich repeat	327..348	CDD:275380	5/24 (21%)
		LRRCT	359..398	CDD:214507	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000