DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10492 and ZCCHC2

DIOPT Version :9

Sequence 1:	NP_001097179.1	Gene:	CG10492 / 35177	FlyBaseID:	FBgn0032748	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_060212.4	Gene:	ZCCHC2 / 54877	HGNCID:	22916	Length:	1178	Species:	Homo sapiens

Alignment Length:	1174	Identity:	242/1174 - (20%)
Similarity:	372/1174 - (31%)	Gaps:	486/1174 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KQDVLQWFE-KLESYNRIETMYALLTACLPFELRFLGTLLEEQGRCDSETLRGMELRAN---NPH 64
            ::.|.:||. .|.|..|:|.|..||..|.|.||||||:.||:..|.|...||..|.:||   :|.
Human    95 QERVYEWFGLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPG 159

  Fly    65 ELAADMVNCQKGDPTDRKIRRKMALYLALIRACNRNCVSEIYRTL-----------ECWGECDFS 118
            .||         |..:..:|.::.:||||:.:.||.....::|.|           ...||....
Human   160 PLA---------DFREPAVRSRLIVYLALLGSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRG 215

  Fly   119 CIND---------QD------------------------TLLELLLVYTMAAIHPVFSMEEQKKI 150
            ...|         ||                        ...||||::|||::||.||..::..:
Human   216 GAEDERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHPAFSFHQRVTL 280

  Fly   151 FGILAKIK----------ENKLVAERFA-PQMQRQTQTPVLQHPHPPSPHDLVIQQQPPHVIHQI 204
            ...|.:::          |.::...:|| |:.|..            |.|...:|.....:|.|.
Human   281 REHLERLRAALRGGPEDAEVEVEPCKFAGPRAQNN------------SAHGDYMQNNESSLIEQA 333

  Fly   205 PGPQQ---APPHPQHPQMVQVLQTPQGNIPMIFPQHFQKLLPS-------------------SD- 246
            |.||.   ..||....:.|                |.:|::..                   ||
Human   334 PIPQDGLTVAPHRAQREAV----------------HIEKIMLKGVQRKRADKYWEYTFKVNWSDL 382

  Fly   247 ------GTHQISVDGMPHLMQPNITIPADTSA------IISHQNTGWTMRHYVPQPPHQQPALQQ 299
                  .|||       .|.:..:.:|.:.|:      |:...|.| :::....:.|..:|.|:|
Human   383 SVTTVTKTHQ-------ELQEFLLKLPKELSSETFDKTILRALNQG-SLKREERRHPDLEPILRQ 439

  Fly   300 ---------QQPQSLDHQVPPASSPMLSQQSSPSSSRTTSPQRDRSLINVPLQAQQQPHQQQQMR 355
                     .|.|.:.......||..|...::..||..||    :.|.::...:.:...|::.:
Human   440 LFSSSSQAFLQSQKVHSFFQSISSDSLHSINNLQSSLKTS----KILEHLKEDSSEASSQEEDV- 499

  Fly   356 GMSQRMADQKNTRRPSAETTPPPTSIGGEQQHDSVNEGGSSNS--SGTSLHRLIRNGFPRLGHNH 418
             :...:..:|:|.:...                 ||..|:|.|  .|.::....:||..    :.
Human   500 -LQHAIIHKKHTGKSPI-----------------VNNIGTSCSPLDGLTMQYSEQNGIV----DW 542

  Fly   419 RVKANTFI--PQH------QQQQQQHHFQNPNYNM---NVMMQSMNINDDGSGSMMNSMN-STKS 471
            |.::.|.|  |:|      |...::....:.|...   ....:.:...|:...|.:|.:. ||..
Human   543 RKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQ 607

  Fly   472 AATTGS------ESGSSNGSCGDLSPSETPTPTQLSLPLH------------------NSVDAG- 511
            .|..|:      :.||.:.:||:.|.....:|   |.|.|                  ||.|:|
Human   608 HAHGGTVKDVNLDIGSGHDTCGETSSESYSSP---SSPRHDGRESFESEEEKDRDTDSNSEDSGN 669

  Fly   512 -----------MGMITTVLP----TGLGN----------YQPKPHHFSYKQQQQQMNLQQRLNGR 551
                       :....||.|    ..|||          ..||..|.|:......:.       .
Human   670 PSTTRFTGYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVM-------H 727

  Fly   552 NGMDKTYQQV--------YTTG--TPSIVSDAQTISSASL-------------QQQQPQTLLISQ 593
            ||..|:...|        .|.|  .||.|:.:....||:.             :.::...||.|.
Human   728 NGAQKSEVVVPAPKPADGKTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASP 792

  Fly   594 SPV--------STPTTTVLLQ------------------PQQPPPT----TYNTSY-PYHQRGPP 627
            .|:        |||...:.:|                  |||||.:    :.||:: |.|..|..
Human   793 LPIPSTFLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQPPGSLSIASPNTAFIPIHNPGSF 857

  Fly   628 P----------------------------------PQQTIFQA-------HSAPPPQTVRGGFRY 651
            |                                  ||.|..:.       .:|.||.:      |
Human   858 PGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPAS------Y 916

  Fly   652 PM--GP------PHNGELIYPTFHTSLAFLPMTAG------GTPTAV-----------TPAQLQS 691
            |:  .|      |.....:..|..||..  |.:||      ..|.||           :||...|
Human   917 PLPGSPLAAGVLPSQNSSVLSTAATSPQ--PASAGISQAQATVPPAVPTHTPGPAPSPSPALTHS 979

  Fly   692 TAAVVSTNAVSV-------QTVPTPQQQ------------------------------------Q 713
            ||...||:.:|.       .||..|||.                                    :
Human   980 TAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSCGRRCSCGTNGNLQLNSYYYPNPMPGPMYR 1044

  Fly   714 VPS-----------------------------TTPY-SALTVCPITG----------AGGG---- 734
            |||                             .||| :.|...|:.|          ||.|
Human  1045 VPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDPVMGSQANYGMQQMAGFGRFYP 1109

  Fly   735 ------------GTAPKV---ISCYNCGSQTHSGRECQEASMEDVTRSASYKLDY------SETS 778
                        |:.||.   :||||||...|..::|:::||| ..:..:|:|.|      |..:
Human  1110 VYPAPNVVANTSGSGPKKNGNVSCYNCGVSGHYAQDCKQSSME-ANQQGTYRLRYAPPLPPSNDT 1173

  Fly   779 MDSS 782
            :||:
Human  1174 LDSA 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10492	NP_001097179.1	PAT1	<164..>268	CDD:286811	23/133 (17%)
CG10492	NP_001097179.1	PHA03247	<591..702	CDD:223021	43/207 (21%)
ZCCHC2	NP_060212.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..249		5/41 (12%)
		PX_domain	363..461	CDD:295365	17/105 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..683		22/128 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..986		14/51 (27%)
		zf-CCHC	1133..1148	CDD:278525	7/14 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003742
OrthoInspector	1	1.000	-	-		oto88981
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5470
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.870