DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn3 and RPN3

DIOPT Version :9

Sequence 1:	NP_001260557.1	Gene:	Rpn3 / 35176	FlyBaseID:	FBgn0261396	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_010938.1	Gene:	RPN3 / 856742	SGDID:	S000000823	Length:	523	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	166/514 - (32%)
Similarity:	283/514 - (55%)	Gaps:	39/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VEMEVDPTA--ETLADEKKNQDVAAVQEIREQIRQIEKGVASKESRFILRVLRNLPNTRRK--LN 72
            |.|:||.:.  :....|||..:...|||:.:.:.:|.|...:.:.|:|.|.|::|.:.|.:  ||
Yeast     6 VMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTTLTLDPRYIWRSLKDLSSLRNQELLN 70

  Fly    73 GVVFRNLAQSIYPAGADREAAV---------ALMPAVEKDATELP------DVPKKQVATKAPIA 122
            ..........:||..:..:..:         :.:|...:.....|      :..||.:..   .|
Yeast    71 AETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSVPGSAELRNSYPASFYSVNTEKKTIEV---TA 132

  Fly   123 EVDAYFYLLLLVKLIDASDLKR-AGISADALMAK-ISIQNRRTLDLIGAKSYFY-------FSRV 178
            |::.:.:||:.:.|.|:.:|:: ...:...::.. :...|.|:|:||.||.:||       .:|.
Yeast   133 EINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRSLNLINAKLWFYIYLSHETLARS 197

  Fly   179 AELKNSLEG---IRSFLHARLRTATLRNDFEGQAVLINCLLRNYLHYALYDQADKLVKKSVYPES 240
            :|..||...   :||.:...|:.|:|::|.|.:|:|||.:||::|:....|.|...:.|..||.:
Yeast   198 SEEINSDNQNIILRSTMMKFLKIASLKHDNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHT 262

  Fly   241 -ASNNEWARFLYYLGRIKAAKLEYSDAHKHLVQALRKSPQHA-AIGFRQTVQKLIIVVELLLGNI 303
             .|::..||:.:||.:|.|.:|:||.|:::::.|:||:|.:: ::||.|...||...::||:|:|
Yeast   263 DVSSSLEARYFFYLSKINAIQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMGDI 327

  Fly   304 PERVVFRQAGLRQSLGAYFQLTQAVRLGNLKRFGDVVSQYGPKFQLDHTFTLIIRLRHNVIKTAI 368
            ||...|.|:.:::||..|:.||:||:||:||:|...:::|......|.|:.|.:|||.|||||.|
Yeast   328 PELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDDTYQLCVRLRSNVIKTGI 392

  Fly   369 RSIGLSYSRISPQDIAKRLMLDSAEDAEFIVSKAIRDGVIEATLDPAQNFMRSKESTDIYSTREP 433
            |.|.|:|.:||.:||..:|.|||.:..|::||:|||||||||.::....|:.:.|..:||.:.:|
Yeast   393 RIISLTYKKISLRDICLKLNLDSEQTVEYMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDP 457

  Fly   434 QLAFHERISFCLNLHNQSVKAMRYPPKSYGKDLESAEERREREQQDLELAKEMAEDDED 492
            |..|.|||.|...||::.:.:||||.   .|..:..|:....|..|..|..::.:|..|
Yeast   458 QQVFDERIKFANQLHDEYLVSMRYPE---DKKTQQNEKSENGENDDDTLDGDLMDDMSD 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn3	NP_001260557.1	PCI	320..413	CDD:279707	47/92 (51%)
Rpn3	NP_001260557.1	Rpn3_C	426..484	CDD:285563	20/57 (35%)
RPN3	NP_010938.1	PCI	343..447	CDD:396121	48/103 (47%)
RPN3	NP_010938.1	Rpn3_C	450..509	CDD:400604	20/61 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341337
Domainoid	1	1.000	116	1.000	Domainoid score	I1311
eggNOG	1	0.900	-	-		E1_KOG2581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2102
Inparanoid	1	1.050	243	1.000	Inparanoid score	I682
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54652
OrthoFinder	1	1.000	-	-		FOG0004490
OrthoInspector	1	1.000	-	-		oto100008
orthoMCL	1	0.900	-	-		OOG6_101680
Panther	1	1.100	-	-	LDO	PTHR10758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1204
SonicParanoid	1	1.000	-	-		X3183
TreeFam	1	0.960	-	-
	15	14.790