DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn3 and psmd3

DIOPT Version :9

Sequence 1:	NP_001260557.1	Gene:	Rpn3 / 35176	FlyBaseID:	FBgn0261396	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_956866.1	Gene:	psmd3 / 393544	ZFINID:	ZDB-GENE-040426-1444	Length:	503	Species:	Danio rerio

Alignment Length:	489	Identity:	287/489 - (58%)
Similarity:	356/489 - (72%)	Gaps:	13/489 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DVEMEVDPTAETLADEKKNQ---DVAAVQEIREQIRQIEKGVASKESRFILRVLRNLPNTRRKLN 72
            ||||:        .:|::..   |...:.:|||.::||||.|:.||.||:||.||.||:|.|:||
Zfish    22 DVEMK--------EEEQRGARELDQTTLDDIREHVKQIEKAVSGKEPRFVLRALRALPSTSRRLN 78

  Fly    73 GVVFRNLAQSIYPA-GADREAAVALMPAVEKDATELPDVPKKQVATKAP-IAEVDAYFYLLLLVK 135
            ..|........:.| .|.:|..:..:....:...::|..|:...|...| |.||:||..||.:|.
Zfish    79 TNVLHKAVSGFFTANAAGKEFLLGFLEQPVEIEGDVPFRPRTGKAAAVPLIPEVEAYLQLLTVVY 143

  Fly   136 LIDASDLKRAGISADALMAKISIQNRRTLDLIGAKSYFYFSRVAELKNSLEGIRSFLHARLRTAT 200
            |.:......|...:|.|:.||..||||.|||:.||.|:|.|||.|..|.|:.:|||||.||||||
Zfish   144 LTNNKHYTEAQKVSDDLLQKIGSQNRRALDLVAAKCYYYHSRVYEFLNQLDVVRSFLHTRLRTAT 208

  Fly   201 LRNDFEGQAVLINCLLRNYLHYALYDQADKLVKKSVYPESASNNEWARFLYYLGRIKAAKLEYSD 265
            ||:|.:|||.|:|.||||||.|.|||||:|||.|||:||.|:||||||:|||.|||||.:||||:
Zfish   209 LRHDADGQATLLNLLLRNYLQYNLYDQAEKLVSKSVFPELANNNEWARYLYYTGRIKAIQLEYSE 273

  Fly   266 AHKHLVQALRKSPQHAAIGFRQTVQKLIIVVELLLGNIPERVVFRQAGLRQSLGAYFQLTQAVRL 330
            |.:.|..||||:|||.|:||:|||.||:||||||||.||:|:.|||..|::||..||.||||||.
Zfish   274 ARRTLTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRT 338

  Fly   331 GNLKRFGDVVSQYGPKFQLDHTFTLIIRLRHNVIKTAIRSIGLSYSRISPQDIAKRLMLDSAEDA 395
            |||.:|..|:.|:|.|||.|.|:|||||||||||||.:|.|.|||||||..|||::|.|||.|||
Zfish   339 GNLAKFNQVLDQFGEKFQTDGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDA 403

  Fly   396 EFIVSKAIRDGVIEATLDPAQNFMRSKESTDIYSTREPQLAFHERISFCLNLHNQSVKAMRYPPK 460
            ||||:||||||||||:::..:.|::|||:.|||||||||||||:||:|||::||.||||||:|||
Zfish   404 EFIVAKAIRDGVIEASINHEKGFVQSKETMDIYSTREPQLAFHQRIAFCLDIHNMSVKAMRFPPK 468

  Fly   461 SYGKDLESAEERREREQQDLELAKEMAEDDEDGF 494
            :|.||||||||||||||||||.||||||||:|.|
Zfish   469 AYNKDLESAEERREREQQDLEFAKEMAEDDDDSF 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn3	NP_001260557.1	PCI	320..413	CDD:279707	66/92 (72%)
Rpn3	NP_001260557.1	Rpn3_C	426..484	CDD:285563	48/57 (84%)
psmd3	NP_956866.1	PCI	327..431	CDD:279707	68/103 (66%)
psmd3	NP_956866.1	Rpn3_C	434..492	CDD:285563	48/57 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1544
eggNOG	1	0.900	-	-		E1_KOG2581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2102
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1142
OMA	1	1.010	-	-		QHG54652
OrthoDB	1	1.010	-	-		D393895at33208
OrthoFinder	1	1.000	-	-		FOG0004490
OrthoInspector	1	1.000	-	-		oto39373
orthoMCL	1	0.900	-	-		OOG6_101680
Panther	1	1.100	-	-	LDO	PTHR10758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1204
SonicParanoid	1	1.000	-	-		X3183
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870