DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn3 and rpn3

DIOPT Version :9

Sequence 1:	NP_001260557.1	Gene:	Rpn3 / 35176	FlyBaseID:	FBgn0261396	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_595282.2	Gene:	rpn3 / 2540109	PomBaseID:	SPBC119.01	Length:	497	Species:	Schizosaccharomyces pombe

Alignment Length:	511	Identity:	211/511 - (41%)
Similarity:	300/511 - (58%)	Gaps:	58/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EMEVDP-TAETLAD--EKKNQDVAAV-----QEIREQIRQIEKGVASKESRFILRVLRNLPNTRR 69
            :|:||. ..|...|  |.|...|..|     |::...|..:.:....::.|.:.|.||...|...
pombe     7 DMQVDSVNQEENVDSGETKQNTVTEVPRTVLQDVEANIAALMQATKQRDPRLVYRSLRTTSNICH 71

  Fly    70 KLNGVVFRNLAQSIYPAGADREAAVALMPAVEKDATELPDVPKKQVATKAPIA---------EVD 125
            :||..|...|.:..|          :...:::.:..||.|:|:....:...|.         |||
pombe    72 RLNADVLGQLIKKYY----------SFDNSLKNELLELIDMPQNGDDSSTSITNGNGNTIFPEVD 126

  Fly   126 AYFYLLLLVKL-------IDASDLKRAGISADALMAKISIQNRRTLDLIGAKSYFYF-------S 176
            .|..|||.:.|       :.|..:|:       ::|::...:|||||.|.||.|||:       :
pombe   127 MYLQLLLSMTLYYNEKYEVGAEYIKK-------VIARLQSYDRRTLDQIAAKLYFYYILFFEKCN 184

  Fly   177 RVAELKNSLEGIRSFLHARLRTATLRNDFEGQAVLINCLLRNYLHYALYDQADKLVKKSVYPESA 241
            |..|.:|:|..:.       |||:||:|.|.||:::..|||||:.:.||||||:||.|:.:..:|
pombe   185 RSVECRNTLLSVH-------RTASLRHDSETQAMVLTLLLRNYIQFNLYDQADRLVSKTSFLTNA 242

  Fly   242 SNNEWARFLYYLGRIKAAKLEYSDAHKHLVQALRKSPQHA-AIGFRQTVQKLIIVVELLLGNIPE 305
            |||...|:.||||||:|.:|:|:.||:|||.|:||:|... |:.|.:.|.||.|||:||:|.|||
pombe   243 SNNLAIRYQYYLGRIRAIQLDYTTAHEHLVSAIRKAPNTVYAVQFLEAVYKLHIVVQLLMGEIPE 307

  Fly   306 RVVFRQAGLRQSLGAYFQLTQAVRLGNLKRFGDVVSQYGPKFQLDHTFTLIIRLRHNVIKTAIRS 370
            |.:|||..|.::|..|.:::||||:|:|..|.|.:|:|..:|:.|..:|||.||||.||||.:|.
pombe   308 RRIFRQKSLEKTLVPYLRISQAVRIGDLCAFTDALSKYEAEFRFDGLYTLICRLRHTVIKTGLRM 372

  Fly   371 IGLSYSRISPQDIAKRLMLDSAEDAEFIVSKAIRDGVIEATLDPAQNFMRSKESTDIYSTREPQL 435
            |.|||||||.:|:..:|.|||.|.||:||:|.||||||:|::|.:..||.|.|:.|||||.:||.
pombe   373 ISLSYSRISLRDVCIKLGLDSEESAEYIVAKGIRDGVIDASIDHSNAFMASNEAMDIYSTEQPQQ 437

  Fly   436 AFHERISFCLNLHNQSVKAMRYPPKSYGKDLESAEERREREQQDLELAKEMAEDDE 491
            ||||||.|||.|||.|:|:||||..::..:||..||.|.|  .|.|:|:...:|||
pombe   438 AFHERIQFCLALHNDSIKSMRYPMDAHKSELEGVEEARRR--MDKEMAEADLDDDE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn3	NP_001260557.1	PCI	320..413	CDD:279707	51/92 (55%)
Rpn3	NP_001260557.1	Rpn3_C	426..484	CDD:285563	33/57 (58%)
rpn3	NP_595282.2	PCI	322..425	CDD:279707	55/102 (54%)
rpn3	NP_595282.2	Rpn3_C	428..483	CDD:285563	33/56 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	170	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E1_KOG2581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2102
Inparanoid	1	1.050	346	1.000	Inparanoid score	I489
OMA	1	1.010	-	-		QHG54652
OrthoFinder	1	1.000	-	-		FOG0004490
OrthoInspector	1	1.000	-	-		oto101732
orthoMCL	1	0.900	-	-		OOG6_101680
Panther	1	1.100	-	-	LDO	PTHR10758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1204
SonicParanoid	1	1.000	-	-		X3183
TreeFam	1	0.960	-	-
	14	13.860