DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn3 and rpn-3

DIOPT Version :9

Sequence 1:	NP_001260557.1	Gene:	Rpn3 / 35176	FlyBaseID:	FBgn0261396	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_498869.1	Gene:	rpn-3 / 176196	WormBaseID:	WBGene00004460	Length:	504	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	218/515 - (42%)
Similarity:	306/515 - (59%)	Gaps:	36/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ATDIGANDVE-MEVDPTAETL--ADEKKNQDVAAVQEIREQIRQIEKGVASKESRFILRVLRNLP 65
            |...|...|| ||||...:.:  .:..|:.:..||:.|:||:..::||    |...|.|||:.||
Worm     2 APKTGETVVEKMEVDEAKQDVPATEPAKDLNAIAVENIKEQLAALDKG----EEHLITRVLQVLP 62

  Fly    66 NTRRKLNGVVFRNLAQSIYPAGADREAAVALM------PAVEKDATELPDVPKKQVATKAP---- 120
            .||:::|..|...|..|  ...:|.:.|..::      ||.:   ||:..:....|.||:|
Worm    63 KTRKQINDNVLYKLVSS--HLSSDAQFAEGMLKYLHYTPAAD---TEVQPMDTSNVKTKSPKKGV 122

  Fly   121 -----IAEVDAYFYLLLLVKLIDASDLKRAGISADALMAKISIQNRRTLDLIGAKSYFYFSRVAE 180
                 ..|.|.|..||:|:.|........|....:..:..|...:|||||.:.||:.::...:.|
Worm   123 KPVFASPESDCYLRLLVLLHLYAQKKNTEALALGENQLTSIYNFDRRTLDGLAAKTLYFLCVIYE 187

  Fly   181 LKNSLEGIRSFLHARLRTATLRNDFEGQAVLINCLLRNYLHYALYDQADKLVKKSVYPESASNNE 245
            .:..|...:.||::|||||||||..|.|||||..|||.||....|..|..||.|..:|::||||:
Worm   188 REGRLFDHQGFLNSRLRTATLRNFSESQAVLICWLLRCYLINRQYQSAAHLVSKVAFPDNASNND 252

  Fly   246 WARFLYYLGRIKAAKLEYSDAHKHLVQALRKSPQHAAIGFRQTVQKLIIVVELLLGNIPERVVFR 310
            .||::||.|||||.:|:|:.|..:.:||.||:||..||||:|.|||.::|:.||.|.||:|.|||
Worm   253 LARYMYYQGRIKALQLDYNSAAGYFLQAQRKAPQEGAIGFKQAVQKWVVVIGLLQGEIPDRSVFR 317

  Fly   311 QAGLRQSLGAYFQLTQAVRLGNLKRFGDVVSQYGPKFQLDHTFTLIIRLRHNVIKTAIRSIGLSY 375
            |...|:.|..|..|::.||.|::.||...:.|:..:|:.|.|.|||:|||.|||||||:.|.|:|
Worm   318 QPIYRKCLAHYLDLSRGVRDGDVARFNHNLEQFKTQFEADDTLTLIVRLRQNVIKTAIKQISLAY 382

  Fly   376 SRISPQDIAKRLMLDSAEDAEFIVSKAIRDGVIEATLD----PAQNFMRSKESTDIYSTREPQLA 436
            |||..:||||:|.:.:..:.|:||:|||.||.|:|.:.    ....:|:|.|:.|||.|.|||..
Worm   383 SRIYIKDIAKKLYITNETETEYIVAKAIADGAIDAVITSDVRDGPRYMQSSETADIYRTSEPQAH 447

  Fly   437 FHERISFCLNLHNQSVKAMRYPPKSYGKDL--ESAEERREREQQDLELAKEMAEDDEDGF 494
            |..||.:||.||||:|||:|||||   |.:  |:.|:.||||||:||.|||:|::|:|.|
Worm   448 FDTRIRYCLELHNQAVKALRYPPK---KKIAVETIEQAREREQQELEFAKELADEDDDDF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn3	NP_001260557.1	PCI	320..413	CDD:279707	45/92 (49%)
Rpn3	NP_001260557.1	Rpn3_C	426..484	CDD:285563	35/59 (59%)
rpn-3	NP_498869.1	PCI	327..419	CDD:279707	45/91 (49%)
rpn-3	NP_498869.1	Rpn3_C	437..494	CDD:285563	35/59 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156125
Domainoid	1	1.000	185	1.000	Domainoid score	I2024
eggNOG	1	0.900	-	-		E1_KOG2581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2102
Inparanoid	1	1.050	351	1.000	Inparanoid score	I1338
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54652
OrthoDB	1	1.010	-	-		D393895at33208
OrthoFinder	1	1.000	-	-		FOG0004490
OrthoInspector	1	1.000	-	-		oto17957
orthoMCL	1	0.900	-	-		OOG6_101680
Panther	1	1.100	-	-	LDO	PTHR10758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1204
SonicParanoid	1	1.000	-	-		X3183
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840