DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acn and acin1a

DIOPT Version :9

Sequence 1:	NP_001260556.1	Gene:	Acn / 35173	FlyBaseID:	FBgn0263198	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_021326935.1	Gene:	acin1a / 368893	ZFINID:	ZDB-GENE-030616-583	Length:	1951	Species:	Danio rerio

Alignment Length:	853	Identity:	254/853 - (29%)
Similarity:	385/853 - (45%)	Gaps:	182/853 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRRRSERKKS----SSP--APVPVAVARRSRRSRKVSENEK-------TEVETPVVAQNNEAECP 52
            :..:|..|||    .:|  ||:|.:|....:|.|..|::.:       |:.::....|.:.|:.|
Zfish  1128 LSHQSSSKKSRFLRDAPVMAPLPSSVGSVLKRPRTFSDSPQPRAPSIPTDSKSKEPVQEDAAQAP 1192

  Fly    53 KVPPASQEINEARASSEERAGSGASPVRR------SRGSRTTPRKRTESKGGDKKVDTIPEEEPE 111
            :....:...::....:.|.|...:.|...      |..|:.|..| |.:...|.|..:.||||.:
Zfish  1193 QTSVLTSGPHDLERKTPEVAVKQSVPQENIQTSEDSEASKDTKHK-TLTGVEDVKKSSTPEEEKK 1256

  Fly   112 NGKDVEKDAVEEEKTVAPPAANESESE-------------DRAKTEDQQAQDDESCAEPAVVKDD 163
            .|:..|| .||:::..:..::|.|.|:             ..:.:....:::::||:.....:.:
Zfish  1257 RGRAREK-KVEKKERKSSSSSNTSSSDSDSGSSSSRSSSSSSSSSSSSSSEEEKSCSASGGRRSE 1320

  Fly   164 DVEKEDLKPQQEVPTSTDDDTKQSEPEQEVKVPSPSSK------------DEEHLKTTSDVLDIQ 216
            :| |.|...|   ||.....|....|      |:|..|            :.|.::.....||:|
Zfish  1321 EV-KRDSSSQ---PTEKVCQTVAENP------PAPQRKKRVFTEKEEKDVNNEVIQNKKPCLDLQ 1375

  Fly   217 TEEVDERDEEASAPAERRETKKRHKEQIKEQQPAEEEEHKENHKQIDENPEQIHDEPADLSNDKH 281
            ..:..:.|.|..|...:..|:...||.:..:.....|..:|:......:..:|     .:|:.|.
Zfish  1376 DGKETKEDIEEDADTNKDTTRSEVKEAVMSEPEKVSESGEESTMAKTFSARRI-----SISSSKA 1435

  Fly   282 DPCLNSS-----ATNTTGAPVLQQQRSVRKRKW-----LTNKKSSDRTPPVLAISTDSLKNIIAD 336
            .|.:.||     ..::.||.        |||:|     :|.||      |.::|:|||||::|.|
Zfish  1436 SPGVGSSEGEAETASSAGAG--------RKRRWGSSTAVTAKK------PSISITTDSLKSLIPD 1486

  Fly   337 VVQPV------PLSDVQLESSSEEEGLVTSDRDSE--RSASPAPPSEA-------SKDRDNKGNT 386
            :...|      .|...::..|.||||...||.|.:  |:.:...|||.       ||..|::...
Zfish  1487 IKPSVGQEAVLDLHPEEMHLSGEEEGGERSDHDLKIRRTVTQIVPSETQENGQKESKRSDHEDEE 1551

  Fly   387 ANT-----------CDTTAEASADNEGAGAAPPAAADTVS-------AQVSLSKATVSTAAPHIV 433
            ..|           .:.:.:.|.:.|.:.........|||       ..:|..|:.||......|
Zfish  1552 ETTEERDRISPEEKTEGSLQVSMETEPSSPGRDVDMKTVSPSDTRIRRSISQQKSGVSITIDDPV 1616

  Fly   434 R---DPSPARNRASHVLYITNLVRPFTVLQLKGLLARTGKIVEEDGFWIDRIKSKCYVAYSTEDE 495
            |   .|||.|.:.|:::::.|||||||:.|||.||.|||.:||| .||||:|||.|||.||:.:|
Zfish  1617 RTAKQPSPPRGKLSNIVHVCNLVRPFTLGQLKELLNRTGTVVEE-SFWIDKIKSHCYVTYSSAEE 1680

  Fly   496 AIETRHALHGVRWPVSNPKCLNVDFGSRTDMD--RAILSTKDEAPRYGQENTRDNQQSG------ 552
            |:.||.|||||:||.||||.|:|||.::.::|  |.:....::.|    |:.|....:|
Zfish  1681 AMATRTALHGVKWPQSNPKFLSVDFCTQDELDFHRGLGPAGEKPP----EDARGAAAAGPGRPMP 1741

  Fly   553 -------NAWS--RLEPSDKKPARPVREWDVGKKEPSDHDKHSNDRRRDSKDRLDSRSRDAERAG 608
                   :.|:  ..|...::.||..||||                 ||       :.||..:.|
Zfish  1742 VPLLPERDQWAEREREMERRERARAEREWD-----------------RD-------KVRDFSKPG 1782

  Fly   609 QERKRSRDREGRGRDRERERLDRNAHARSRSGSPASKTKKENEPPIRLLDDLFRKTKGTPCIYWL 673
            ::|:... |..|.|||||.|.:|   .:|:......|.|...|||.:||||||||||..||||||
Zfish  1783 EDREPGA-RRSRSRDRERRRKER---GKSKERKADKKEKGPEEPPAKLLDDLFRKTKAAPCIYWL 1843

  Fly   674 PLTPEAIAEKEAFRQKRIEEHKLRIKEREERQ-KEREKDRDRQR---------ETRRNRSNERRR 728
            |||.|..|::.|.|.:|:.|.:.||||.||.: |:||::| |:|         |..|.|..||.|
Zfish  1844 PLTEEQAAQRAAARAERMREREKRIKEMEEEEGKKREEER-RERMKPSGTAGGEGERGRDRERER 1907

  Fly   729 SRSRERER 736
            .|.|||||
Zfish  1908 DRGRERER 1915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acn	NP_001260556.1	RRM_ACINU	444..530	CDD:240878	52/87 (60%)
Acn	NP_001260556.1	RSB_motif	600..691	CDD:292910	42/90 (47%)
acin1a	XP_021326935.1	SAP	32..66	CDD:307935
		PARP_reg	34..>173	CDD:332154
		Pkinase	<449..>523	CDD:330832
		Neuromodulin_N	<662..1417	CDD:331332	62/300 (21%)
		RRM_ACINU	1630..1718	CDD:240878	52/88 (59%)
		RSB_motif	1771..1846	CDD:318514	39/102 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596490
Domainoid	1	1.000	165	1.000	Domainoid score	I3864
eggNOG	1	0.900	-	-		E1_KOG2416
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3001
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005012
OrthoInspector	1	1.000	-	-		otm24718
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46589
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5471
SonicParanoid	1	1.000	-	-		X3543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.010