Protein Alignment Acn and ACIN1

DIOPT Version :10

• Sequence 1: NP_609935.1
• Gene: Acn / 35173
• FlyBaseID: FBgn0263198
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_054231585.1
• Gene: ACIN1 / 22985
• HGNCID: 17066
• Length: 1342
• Species: Homo sapiens
• Alignment Length: 871
• Identity: 256/871 - (29%)
• Similarity: 382/871 - (43%)
• Gaps: 229/871 - (26%)

  Fly     6 ERKKSSSPAPVPVAVARRSRRSRKVSENEKTEVETPVVAQNNEAECPKVPPASQE---------- 60
            |..:|:.|.|:                    ::|...:|:....||.|.|...|:
Human   521 ESDRSAQPLPL--------------------KIEELALAKGITEECLKQPSLEQKEGRRASHTLL 565

  Fly    61 ----INEARASSEERAGSGASPVRRSR-------GSRT-TPRKRTESKGGDKKVDTIPEEEPENG 113
                :.::..||..|:.|.:|...|||       |||: :|.:..:......:....|...|:.|
Human   566 PSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMG 630

  Fly   114 KDVEKDAVEEEKTVAPPAANESESEDRAKTEDQQA-QDDESCAEPAVVKDDD---VEKEDLKPQQ 174
            .               .:.:||.|..|:::..:.| .:......|.|.:|..   .|.:|....|
Human   631 S---------------RSTSESRSRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQ 680

  Fly   175 EVPTSTDDDTKQSEPEQEVKVPSPS---------SKDEEHLKTTSDVLDIQTE-------EVDER 223
            ||.|......:..||::.....|.|         ...|:|:...     :|.|       |.:|.
Human   681 EVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQR-----LQPERGSPKKCEAEEA 740

  Fly   224 DEEASAPAERRETKKRH---KEQIKEQQPAEEE---EHKENHKQID--ENPEQIHDEPADLSND- 279
            :..|:...:..||:..|   .|:|......:||   :..||..:.|  |.|..|.|:   :|||
Human   741 EPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQ---VSNDD 802

  Fly   280 ----------KHDPCL------NSSATNTTGAPV----LQQQRSVRKRKWLTNKKSSDRTPPVLA 324
                      |.:..|      ..|..:|.|.|.    .:..:..|||:|..:..::.:.|.: :
Human   803 RPEGSVEDEEKKESSLPKSFKRKISVVSTKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSI-S 866

  Fly   325 ISTDSLKNIIADVVQPVPLSDVQLESSSEEEGLVTSDRDSERSASPAPPSEASKDRDNKGNTANT 389
            |:|:|||::|.| ::|:...:..::..:::..:  |:.::||:.     .:.:.|:..|     .
Human   867 ITTESLKSLIPD-IKPLAGQEAVVDLHADDSRI--SEDETERNG-----DDGTHDKGLK-----I 918

  Fly   390 CDT-TAEASADNEGAG-------------------------AAPPAA---------ADTVSAQ-V 418
            |.| |....|:.:..|                         |.||.|         .||::.: :
Human   919 CRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSI 983

  Fly   419 SLSKATVSTAAPHIVRD---PSPARNRASHVLYITNLVRPFTVLQLKGLLARTGKIVEEDGFWID 480
            |..|:.||......||.   |||.|.:.|::::|:|||||||:.|||.||.|||.:||| .||||
Human   984 SQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEE-AFWID 1047

  Fly   481 RIKSKCYVAYSTEDEAIETRHALHGVRWPVSNPKCLNVDFGSRTDMD--RAIL-----STKDE-- 536
            :|||.|:|.|||.:||:.||.|||||:||.||||.|..|:..:.::|  |.:|     .||.|
Human  1048 KIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQ 1112

  Fly   537 -APRYGQENTRDNQQSGNAWSRLEPSDKKPARPVREWDVGKKEPSDHDK-HSNDRRRDSKDRLDS 599
             .||                    |....|..||        :|..|.: ...::.|..:::...
Human  1113 GIPR--------------------PLHPPPPPPV--------QPPQHPRAEQREQERAVREQWAE 1149

  Fly   600 RSRDAERAGQERKRS-----RD--REG---RGRDRERERLDRNAHARSRSGSPASKTKKENEPPI 654
            |.|:.||  :||.||     ||  |||   |.|.|:|.|.:|   |:|:......|.|.:.|||.
Human  1150 REREMER--RERTRSEREWDRDKVREGPRSRSRSRDRRRKER---AKSKEKKSEKKEKAQEEPPA 1209

  Fly   655 RLLDDLFRKTKGTPCIYWLPLTPEAIAEKEAFRQKRIEEHKLRIKERE-----ERQKEREKDRDR 714
            :||||||||||..|||||||||...|.:|||.|.:|.:|.:.|.||:|     ||:||.|::|:|
Human  1210 KLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNR 1274

  Fly   715 Q--RETRRNRSNERRRSRSRERERRR 738
            |  ||.||..|.||.|.|.|||||.|
Human  1275 QLEREKRREHSRERDRERERERERDR 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acn	NP_609935.1	PTZ00121	<50..>251	CDD:173412	50/245 (20%)
		RRM_ACINU	444..530	CDD:409866	51/87 (59%)
		RSB_motif	599..693	CDD:465085	51/103 (50%)
ACIN1	XP_054231585.1	SAP	72..106	CDD:128789
		PTZ00121	<218..412	CDD:173412
		RRM_ACINU	1012..1098	CDD:409866	50/86 (58%)
		RSB_motif	<1207..1237	CDD:465085	22/29 (76%)