DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and KLC4

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_958931.1	Gene:	KLC4 / 89953	HGNCID:	21624	Length:	637	Species:	Homo sapiens

Alignment Length:	279	Identity:	63/279 - (22%)
Similarity:	115/279 - (41%)	Gaps:	48/279 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 IKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAMEREQFKKAEK 158
            :.|:...:..:.|:|  |.:|..:|:.||.:.:.....|  .:....:.:|.|..:|.::|:||.
Human   270 VATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEP 334

  Fly   159 I---FTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKM--P 218
            :   ..::.:::....|    |.:....:.:|.:.|.||..|...:.:    |:...:.|..  |
Human   335 LCQRALEIREKVLGTNH----PDVAKQLNNLALLCQNQGKYEAVERYY----QRALAIYEGQLGP 391

  Fly   219 DDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVNDASVTILNNISVAYVN 282
            |:.::..    |||......:|||||.||:.|:||..... :..:|:|:|....|.
Human   392 DNPNVAR----TKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIW--------- 443

  Fly   283 LEKYAEARETLLEAMELTKELKDATQEGILQA-------------NLGLVYLREGLMSQAENACR 334
              .:||.||.:.::.........|...|..:|             |||.:|.|:|.:..||....
Human   444 --MHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEE 506

  Fly   335 LAWKLGKQHQNPDAVEQAE 353
            .|  |..:.|..|.:.|.:
Human   507 CA--LRSRRQGTDPISQTK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	18/67 (27%)
		TPR repeat	269..299	CDD:276809	5/29 (17%)
		TPR_11	272..339	CDD:290150	17/79 (22%)
		TPR repeat	304..338	CDD:276809	12/46 (26%)
KLC4	NP_958931.1	SMC_N	51..>166	CDD:330553
		TPR_12	228..303	CDD:315987	8/32 (25%)
		TPR repeat	230..257	CDD:276809
		TPR_12	269..345	CDD:315987	15/74 (20%)
		TPR repeat	271..299	CDD:276809	7/27 (26%)
		TPR_12	312..386	CDD:315987	14/81 (17%)
		TPR repeat	313..341	CDD:276809	6/27 (22%)
		TPR_12	353..427	CDD:315987	22/81 (27%)
		TPR repeat	354..384	CDD:276809	6/33 (18%)
		TPR_12	396..514	CDD:315987	34/134 (25%)
		TPR repeat	397..424	CDD:276809	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810