DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc19 and Ttc19

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_082636.3	Gene:	Ttc19 / 72795	MGIID:	1920045	Length:	365	Species:	Mus musculus

Alignment Length:	344	Identity:	76/344 - (22%)
Similarity:	150/344 - (43%)	Gaps:	84/344 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPEEKLIKTIKRSILC 107
            |..||.:     .::|.:.||:.:..               .|.|..:|. |.::|:.:|::.|.
Mouse    54 GVLPLLA-----ALAWFSRPAATAEQ---------------PGEDASDEA-EAEIIQLLKQAKLS 97

  Fly   108 IQREQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGH 172
            |.:::.:.||.:||.|||:|.:..::..|||.:|||||||..|.|.:.||::|...|..|...|.
Mouse    98 IMKDEPEAAELILHDALRLAYESDNRKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGM 162

  Fly   173 TEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDILE------------ 225
            .:|...|:.||.|:|::...|...|.:..|:.:.:..|...:|:   :|::.|
Mouse   163 KQEDNAIIEISLKLANIYAAQNKQEFALAGYEFCISTLEGKIER---EKELAEDIMSEETANTYL 224

  Fly   226 LYGLTKNWFGQLLMKQGKYLEAKNLFKEAFD---------------------TLINVYGAVNDAS 269
            |.|:..:...:.|:...:..:|:.::::|..                     |.::..|..:||.
Mouse   225 LLGMCLDSCARYLLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDDAY 289

  Fly   270 V------------------TILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEGILQANL 316
            :                  .:|:|::...::.|:|.:|:|...||::..:..:|         .:
Mouse   290 IYMQRASDLAREINHPELHMVLSNLAAILIHRERYTQAKEIYQEALKRAELKRD---------EV 345

  Fly   317 GLVYLREGLMSQAENACRL 335
            .:.::||.|...:..:.||
Mouse   346 SVQHIREELAELSRKSRRL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	15/105 (14%)
		TPR repeat	269..299	CDD:276809	8/47 (17%)
		TPR_11	272..339	CDD:290150	14/64 (22%)
		TPR repeat	304..338	CDD:276809	6/32 (19%)
Ttc19	NP_082636.3	TPR 1	127..160		18/32 (56%)
		TPR_12	217..301	CDD:290160	17/134 (13%)
		TPR 2	220..260		8/51 (16%)
		TPR repeat	220..255	CDD:276809	7/46 (15%)
		TPR_12	265..339	CDD:290160	17/112 (15%)
		TPR repeat	268..298	CDD:276809	7/47 (15%)
		TPR 3	269..302		8/50 (16%)
		TPR 4	308..341		4/32 (13%)
		TPR repeat	308..336	CDD:276809	3/27 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850157
Domainoid	1	1.000	81	1.000	Domainoid score	I8502
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9831
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5077
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007221
OrthoInspector	1	1.000	-	-		oto92775
orthoMCL	1	0.900	-	-		OOG6_107899
Panther	1	1.100	-	-	LDO	PTHR13143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750