DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc19 and Ttc19

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_006246592.1	Gene:	Ttc19 / 691506	RGDID:	1582808	Length:	365	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	76/320 - (23%)
Similarity:	140/320 - (43%)	Gaps:	70/320 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PASGSS-----GGMFWAFSAAFTLNLFGGADEKEETPEEKLIKTIKRSILCIQREQYDKAEQMLH 121
            ||.|..     ..:.| ||.........|.|..:|. |.::|:.:||:.|.|.:::.:.||.:||
  Rat    49 PARGHRVLPLLAALAW-FSRTAAAEEQPGEDATDEA-EAEIIQLLKRAKLSIMKDEPEAAELILH 111

  Fly   122 LALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKI 186
            .|||:|.:..:|..|||.:|||||||..|.|.:.||::|...|..|...|..:|...|:.||.|:
  Rat   112 DALRLAYESDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAIVEISLKL 176

  Fly   187 AHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDILE------------LYGLTKNWFGQLLM 239
            |::...|...|.:..|:.:.:..|...:|:   :|::.|            |.|:..:...:.|:
  Rat   177 ANIYAAQNKQEFALAGYEFCISTLEGKIER---EKELAEDIMSEERANTYLLLGMCLDSCARYLL 238

  Fly   240 KQGKYLEAKNLFKEAFD---------------------TLINVYGAVNDASV------------- 270
            ...:..:|:.::::|..                     |.::..|..:||.:
  Rat   239 FSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATALDAQGHFDDAYIYMQRASDLAREIN 303

  Fly   271 -----TILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREGL 325
                 .:|:|::...::.|:|.:|:|...||::..:..:|         ...:.::||.|
  Rat   304 HPELHMVLSNLAAILIHRERYTQAKEIYQEALKQAELKRD---------EFSVQHIREEL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	15/105 (14%)
		TPR repeat	269..299	CDD:276809	8/47 (17%)
		TPR_11	272..339	CDD:290150	12/54 (22%)
		TPR repeat	304..338	CDD:276809	4/22 (18%)
Ttc19	XP_006246592.1	TPR repeat	220..255	CDD:276809	5/55 (9%)
		TPR_12	224..301	CDD:290160	16/115 (14%)
		BRO1_Alix_like	<231..339	CDD:301330	18/121 (15%)
		TPR_12	265..339	CDD:290160	10/48 (21%)
		TPR repeat	268..298	CDD:276809	7/29 (24%)
		TPR repeat	308..336	CDD:276809	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353850
Domainoid	1	1.000	82	1.000	Domainoid score	I8258
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9831
Inparanoid	1	1.050	95	1.000	Inparanoid score	I4968
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369100at33208
OrthoFinder	1	1.000	-	-		FOG0007221
OrthoInspector	1	1.000	-	-		oto96328
orthoMCL	1	0.900	-	-		OOG6_107899
Panther	1	1.100	-	-	LDO	PTHR13143
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800