DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc19 and klc3

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001070646.1	Gene:	klc3 / 569394	ZFINID:	ZDB-GENE-060929-772	Length:	512	Species:	Danio rerio

Alignment Length:	286	Identity:	62/286 - (21%)
Similarity:	114/286 - (39%)	Gaps:	48/286 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ETPEEKLIKTIKRSILCIQ----REQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMANL-AMER 150
            |..::||...::|  ||.:    |::..:|:|.|.   ...|::.:.:........|::: ..:.
Zfish    82 EAEKQKLRAQVRR--LCQENQWLRDELSRAQQQLQ---EREQEVVTLEEQNRHLQFMSSIRKYDH 141

  Fly   151 EQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLE 215
            |:....:|..|...:.|.....|||..:        .||||.......:.|...:.:....:.|.
Zfish   142 EETSLEDKDSTSGKESLDDLFPTEEEEQ--------THMSQPHSSAAAAAQQGGYEIPARLRTLH 198

  Fly   216 KMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAY 280
            .:     :::            ...||:|..|..|.|:|.:.|....|..:....|:||.:::.|
Zfish   199 NL-----VIQ------------YASQGRYEVAVPLCKQALEDLEKSSGHSHPDVATMLNILALVY 246

  Fly   281 VNLEKYAEARETLLEAMELTKELKDATQEGILQA--NLGLVYLREGLMSQAENACRLAWK----- 338
            .:..||.||...|.:|:.:.::........:...  ||.::|.:.|...:||..|:.|.:
Zfish   247 RDQNKYKEAASLLNDALAIREKTLGMDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKV 311

  Fly   339 LGKQHQNPDAVEQ----AEYCLNEIK 360
            ||..|  ||..:|    |..|.|:.|
Zfish   312 LGTDH--PDVAKQLNNLALLCQNQGK 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	19/66 (29%)
		TPR repeat	269..299	CDD:276809	10/29 (34%)
		TPR_11	272..339	CDD:290150	17/73 (23%)
		TPR repeat	304..338	CDD:276809	8/35 (23%)
klc3	NP_001070646.1	TPR_12	191..268	CDD:290160	20/93 (22%)
		TPR_10	194..234	CDD:290111	10/56 (18%)
		TPR repeat	195..222	CDD:276809	8/43 (19%)
		TPR_12	232..310	CDD:290160	18/77 (23%)
		TPR_10	235..275	CDD:290111	10/39 (26%)
		TPR repeat	236..264	CDD:276809	10/27 (37%)
		TPR_12	274..352	CDD:290160	18/64 (28%)
		TPR_10	277..318	CDD:290111	11/42 (26%)
		TPR repeat	278..306	CDD:276809	8/27 (30%)
		TPR_12	316..394	CDD:290160	8/22 (36%)
		TPR_10	319..357	CDD:290111	5/17 (29%)
		TPR repeat	319..349	CDD:276809	5/17 (29%)
		TPR_1	362..394	CDD:278916
		TPR repeat	362..389	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810