DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and AgaP_AGAP011356

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_001688175.1	Gene:	AgaP_AGAP011356 / 5668062	VectorBaseID:	AGAP011356	Length:	475	Species:	Anopheles gambiae

Alignment Length:	349	Identity:	61/349 - (17%)
Similarity:	105/349 - (30%)	Gaps:	108/349 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DYC-------HLAPLKRSRYHQRSEFGCRPLCSNAAG---YEVSWA-----------------AP 61
            :||       .:|.|::.....:.....|.|.|...|   ||..|.                 .|
Mosquito   129 NYCDMLRTELRVASLRKGETRDQPRIRARVLESLRFGDYLYEAGWCRCGAEVLALAQDLLGLLVP 193

  Fly    62 PAS-------------GSSGGMFWAFSAAFTLNLFGGADE-KEETPEEKLIKT-IKRSILCIQRE 111
            ||:             ...|....|.::.....|.....: .|..|:..|:|. ::........:
Mosquito   194 PATRALQLECLVRLLRAQIGACLTARASHTVQRLHAFLQQVGESAPQLPLVKAYLQLGSYYYHVQ 258

  Fly   112 QYDKAEQMLHLALRMA---QDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHT 173
            .||:..|....||..|   .|..:|..:..|..|:|...:.:|:...|..:.:..::|...|
Mosquito   259 DYDRCHQWALRALASAADGDDAPAKGDVIDVLQLIALFCVAKERHDLANMLISQAVQRARTE--- 320

  Fly   174 EESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDILELYGLTKNWFGQLL 238
                               .|.|.:.:                    .|:|:.||.       :|
Mosquito   321 -------------------YGGLHRKY--------------------ADVLQQYGF-------VL 339

  Fly   239 MKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTI--------------LNNISVAYVNLEKYAEA 289
            ::....|.|...|.|..|....|||.::..:|.:              .....:|..:.|...|.
Mosquito   340 LRMNAILPAITAFTECLDVTGRVYGLLSPHAVVLEGYLAHCLYLRSHTTGRFDMALRHAETALEL 404

  Fly   290 RETLLEAMELTKELKDATQEGILQ 313
            ...|:.|....:|..:.|::.||:
Mosquito   405 ASQLMPASRRVREQLERTRDLILR 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	15/80 (19%)
		TPR repeat	269..299	CDD:276809	6/43 (14%)
		TPR_11	272..339	CDD:290150	9/56 (16%)
		TPR repeat	304..338	CDD:276809	3/10 (30%)
AgaP_AGAP011356	XP_001688175.1	TPR repeat	244..272	CDD:276809	5/27 (19%)
		TPR_12	285..358	CDD:290160	18/121 (15%)
		TPR repeat	286..324	CDD:276809	8/59 (14%)
		TPR_11	329..405	CDD:290150	17/82 (21%)
		TPR repeat	329..357	CDD:276809	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900