DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and nphp3

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001189370.1	Gene:	nphp3 / 562601	ZFINID:	ZDB-GENE-091204-117	Length:	1303	Species:	Danio rerio

Alignment Length:	405	Identity:	75/405 - (18%)
Similarity:	135/405 - (33%)	Gaps:	145/405 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LAPLKRS-----------------RYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFS 75
            :|||:||                 ..||            .||..|.|
Zfish   941 VAPLQRSLEIRETALDPDHPSVAQSLHQ------------LAGVYVHW----------------- 976

  Fly    76 AAFTLNLFGGAD----------EKEETPEEKLIKTIKR-----SILCIQREQYDKAEQMLHLALR 125
                 ..||.|:          |....||.   .|:.|     |:|..::.:|::||::...:::
Zfish   977 -----RKFGNAEQLYKQAMEICENAYGPEH---STVARELDSLSLLYQKQNKYEQAEKLRKRSVK 1033

  Fly   126 MAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMS 190
            :.|....:.|..|.|.|:...|::.|:.... |..||..|.|                :::..:.
Zfish  1034 IRQKTARQKGHMYGFALLKRRALQLEELTLG-KDSTDCAKTL----------------NELGVLY 1081

  Fly   191 QLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDIL--------------------ELY-------- 227
            .||.:|:.:....|.:|:...::|.  ||..|..                    |||
Zfish  1082 YLQNNLDAAKLFLTRSLEMRQRVLG--PDHPDCAQSLNNLAALHSERKEYESAEELYERALDIRK 1144

  Fly   228 ----------GLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVN 282
                      ..|......|..::||..:|..|::.|.:.....:|..:.:..|.|.|::|.|..
Zfish  1145 RALAPDHPSLAYTLKHLAMLYKRRGKLEKAVPLYELALEIREKSFGPKHPSVATALVNLAVLYCQ 1209

  Fly   283 LEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREG-------LMSQAENACRLAWKLG 340
            |:::::|......|::            :.:.:||.::.|.|       ::|..|.....|.:|.
Zfish  1210 LKQHSDALPLYERALK------------VYEDSLGRLHPRVGETLKNLAVLSYEEGDFEKAAELY 1262

  Fly   341 KQHQNPDAVEQAEYC 355
            |:.......|.:..|
Zfish  1263 KRAMEIKEAEPSLVC 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	15/66 (23%)
		TPR repeat	269..299	CDD:276809	8/29 (28%)
		TPR_11	272..339	CDD:290150	14/73 (19%)
		TPR repeat	304..338	CDD:276809	7/40 (18%)
nphp3	NP_001189370.1	Uso1_p115_C	90..180	CDD:282695
		OmpH	<101..>186	CDD:281871
		TPR 1	449..482
		TPR 2	802..840
		TPR_12	920..995	CDD:290160	14/87 (16%)
		TPR_10	920..960	CDD:290111	5/18 (28%)
		TPR 3	921..954		5/12 (42%)
		TPR repeat	921..949	CDD:276809	5/7 (71%)
		TPR_12	959..1037	CDD:290160	19/114 (17%)
		TPR_10	962..1001	CDD:290111	11/72 (15%)
		TPR repeat	962..992	CDD:276809	9/63 (14%)
		TPR 4	963..996		10/66 (15%)
		TPR repeat	1005..1057	CDD:276809	12/51 (24%)
		TPR 5	1005..1038		7/32 (22%)
		TPR_12	1069..1145	CDD:290160	15/93 (16%)
		TPR_10	1071..1111	CDD:290111	10/57 (18%)
		TPR 6	1071..1104		7/48 (15%)
		TPR repeat	1071..1099	CDD:276809	6/43 (14%)
		TPR_12	1109..1187	CDD:290160	11/77 (14%)
		TPR_10	1113..1152	CDD:290111	3/38 (8%)
		TPR 7	1113..1146		3/32 (9%)
		TPR repeat	1113..1141	CDD:276809	3/27 (11%)
		TPR_12	1151..1229	CDD:290160	16/89 (18%)
		TPR_10	1154..1194	CDD:290111	8/39 (21%)
		TPR 8	1155..1188		7/32 (22%)
		TPR repeat	1155..1183	CDD:276809	7/27 (26%)
		TPR_12	1193..1271	CDD:290160	17/89 (19%)
		TPR_10	1196..1237	CDD:290111	10/52 (19%)
		TPR repeat	1196..1234	CDD:276809	10/49 (20%)
		TPR 9	1197..1230		8/44 (18%)
		TPR 10	1239..1272		6/32 (19%)
		TPR repeat	1239..1267	CDD:276809	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1276..1303		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900