DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and TTC19

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_060245.3	Gene:	TTC19 / 54902	HGNCID:	26006	Length:	380	Species:	Homo sapiens

Alignment Length:	348	Identity:	86/348 - (24%)
Similarity:	151/348 - (43%)	Gaps:	78/348 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PLKRSRYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPE 94
            |..|...|.|.. |..||.:     .::|.:.||:........|..||..    .||||    .|
Human    43 PPSRVAPHGRGP-GLLPLLA-----ALAWFSRPAAAEEEEQQGADGAAAE----DGADE----AE 93

  Fly    95 EKLIKTIKRSILCIQREQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKI 159
            .::|:.:||:.|.|.:::.::||.:||.|||:|....:|..|||.:|||||||..|.|.:.||::
Human    94 AEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQL 158

  Fly   160 FTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDIL 224
            |...|..|...|..:|...|:.||.|:|.:...|...|.:..|:.:.:..|.   ||:..:|::.
Human   159 FKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLE---EKIEREKELA 220

  Fly   225 E-------------LYGLTKNWFGQLLMKQGKYLEAKNLFKEAFD-------------------- 256
            |             |.|:..:...:.|:...:..:|:.::::|..
Human   221 EDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDL 285

  Fly   257 -TLINVYGAVNDASV------------------TILNNISVAYVNLEKYAEARETLLEAMELTKE 302
             |.::..|..::|.:                  .:|:|::...::.|:|.:|:|...||::..|.
Human   286 ATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKL 350

  Fly   303 LKDATQEGILQANLGLVYLREGL 325
            .||         .:.:.::||.|
Human   351 KKD---------EISVQHIREEL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	14/105 (13%)
		TPR repeat	269..299	CDD:276809	8/47 (17%)
		TPR_11	272..339	CDD:290150	14/54 (26%)
		TPR repeat	304..338	CDD:276809	5/22 (23%)
TTC19	NP_060245.3	TPR 1	136..169		16/32 (50%)
		TPR 2	179..212		8/35 (23%)
		TPR_12	233..311	CDD:290160	8/77 (10%)
		TPR 3	237..270		4/32 (13%)
		TPR_12	275..349	CDD:290160	11/73 (15%)
		TPR repeat	278..308	CDD:276809	3/29 (10%)
		TPR 4	279..312		3/32 (9%)
		TPR 5	318..351		9/32 (28%)
		TPR repeat	318..346	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159787
Domainoid	1	1.000	84	1.000	Domainoid score	I8293
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9831
Inparanoid	1	1.050	98	1.000	Inparanoid score	I5032
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007221
OrthoInspector	1	1.000	-	-		oto89208
orthoMCL	1	0.900	-	-		OOG6_107899
Panther	1	1.100	-	-	LDO	PTHR13143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.750