DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and Klc

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	69/304 - (22%)
Similarity:	130/304 - (42%)	Gaps:	72/304 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 IKTIKRSILCIQREQ--YDKAEQMLH--LALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAE- 157
            :.|:...:..:.|:|  |.:|..:|:  |::|.....::...:....:.:|.|..:|.::|.||
  Fly   227 VATMLNILALVYRDQNKYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEP 291

  Fly   158 --KIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQG---DLEKSFQGFTWTLQQLAKLLEKM 217
              |...::.:::..:.|    |.:....:.:|.:.|.||   ::||.:|      :.|.....|:
  Fly   292 LCKRALEIREKVLGKDH----PDVAKQLNNLALLCQNQGKYDEVEKYYQ------RALDIYESKL 346

  Fly   218 -PDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVNDASVTILNNISVAY 280
             |||.::.:    |||......:|||:|.||:.|:|:..... ...:||::..:..|.   .||.
  Fly   347 GPDDPNVAK----TKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFGAIDSKNKPIW---QVAE 404

  Fly   281 VNLEKYAEARETL-------------LEAMELTKELKDATQEGILQANLGLVYLREGLMSQAENA 332
            ...|...:.||..             :::..:|..||          |||.:|.|:|:...||..
  Fly   405 EREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLK----------NLGALYRRQGMFEAAETL 459

  Fly   333 --CRL-----AWKLGKQHQNPDAVEQAEYCLNEIKTTLNGEKRQ 369
              |.:     |:.|.||.:           |:::.|  :.|||:
  Fly   460 EDCAMRSKKEAYDLAKQTK-----------LSQLLT--SNEKRR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	17/80 (21%)
		TPR repeat	269..299	CDD:276809	6/42 (14%)
		TPR_11	272..339	CDD:290150	19/86 (22%)
		TPR repeat	304..338	CDD:276809	11/40 (28%)
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	7/30 (23%)
		TPR repeat	187..214	CDD:276809
		TPR_12	226..302	CDD:315987	15/74 (20%)
		TPR repeat	228..256	CDD:276809	6/27 (22%)
		TPR_12	269..344	CDD:315987	17/84 (20%)
		TPR repeat	270..298	CDD:276809	7/27 (26%)
		TPR_12	310..384	CDD:315987	23/83 (28%)
		TPR repeat	311..341	CDD:276809	8/35 (23%)
		TPR_12	353..469	CDD:315987	31/132 (23%)
		TPR repeat	354..381	CDD:276809	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810