DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and klc1a

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_005156690.1	Gene:	klc1a / 393928	ZFINID:	ZDB-GENE-040426-1599	Length:	647	Species:	Danio rerio

Alignment Length:	283	Identity:	65/283 - (22%)
Similarity:	118/283 - (41%)	Gaps:	57/283 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EKEETPEEKLIKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAM 148
            ||....:...:.|:...:..:.|:|  |.:|..:|:.||.:.:....:|  .:....:.:|.|..
Zfish   249 EKTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYG 313

  Fly   149 EREQFKKAE---KIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQL 210
            :|.::|:||   |...::.:::..:.|    |.:....:.:|.:.|.||..|:    ..:..|:.
Zfish   314 KRGKYKEAEPLCKRALEIREKVLGKDH----PDVAKQLNNLALLCQNQGKYEE----VEYYYQRA 370

  Fly   211 AKLLEKM--PDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVNDASVTI 272
            .::.:..  |||.::.:    |||......:||||:.:|:.|:||..... ...:|:|:|.:..|
Zfish   371 LEIYQTKLGPDDPNVAK----TKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPI 431

  Fly   273 LNNISVAYVNLEKYAEARETLLEAMELTK-ELKDATQEG-----------------ILQANLGLV 319
            .           .:||.||      |.:| :.||.|..|                 ....|||.:
Zfish   432 W-----------MHAEERE------EQSKIKQKDGTPFGEYGGWYKACKVDSPTVTTTLKNLGAL 479

  Fly   320 YLREGLMSQAENACRLAWKLGKQ 342
            |.|:|....||.....|.:..||
Zfish   480 YRRQGKFEAAETLEEAALRSRKQ 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	18/68 (26%)
		TPR repeat	269..299	CDD:276809	5/29 (17%)
		TPR_11	272..339	CDD:290150	20/84 (24%)
		TPR repeat	304..338	CDD:276809	13/50 (26%)
klc1a	XP_005156690.1	TPR_12	215..292	CDD:290160	10/42 (24%)
		TPR_10	218..258	CDD:290111	2/8 (25%)
		TPR repeat	219..246	CDD:276809
		TPR_12	256..334	CDD:290160	16/77 (21%)
		TPR_10	259..299	CDD:290111	9/39 (23%)
		TPR repeat	260..288	CDD:276809	7/27 (26%)
		TPR_12	298..375	CDD:290160	15/84 (18%)
		TPR_10	301..342	CDD:290111	8/44 (18%)
		TPR repeat	302..330	CDD:276809	7/27 (26%)
		TPR_12	340..418	CDD:290160	22/89 (25%)
		TPR_10	343..384	CDD:290111	9/44 (20%)
		TPR repeat	343..373	CDD:276809	6/33 (18%)
		TPR_10	385..422	CDD:290111	11/40 (28%)
		TPR repeat	386..413	CDD:276809	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910