DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ttc19 and Nphp3

DIOPT Version :9

Sequence 1:NP_609934.3 Gene:Ttc19 / 35172 FlyBaseID:FBgn0032744 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_001178811.1 Gene:Nphp3 / 363126 RGDID:1563856 Length:1325 Species:Rattus norvegicus


Alignment Length:349 Identity:70/349 - (20%)
Similarity:132/349 - (37%) Gaps:89/349 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LAPL--KRSRYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTL-NLFGGADEK 89
            ||.|  |:::|.|...|..:.:.       :...|....||..|.......|..| .|..|.|:.
  Rat  1028 LATLYHKQNKYEQAERFRKKSVI-------IRQQATRRKGSLYGFALLRRRALQLEELTLGKDKP 1085

  Fly    90 EETPEEKLIKTIKR-SILCIQREQYDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAMERE 151
            |..      :|:.. .:|...:...:.|||.|..:|.|.:.:...|  ......:.:|.|..||:
  Rat  1086 ENA------RTLNELGVLYYLQNNLETAEQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNERK 1144

  Fly   152 QFKKAEKIF---TDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKL 213
            |:.:||:::   .|:.:|..|..|    |.:                        .:|::.||.|
  Rat  1145 QYARAEELYERALDIRRRALAPDH----PSL------------------------AYTVKHLAIL 1181

  Fly   214 LEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISV 278
            .:                        |.|:..:|..|::.|.:.....:|..:.:..|.|.|::|
  Rat  1182 YK------------------------KTGRVDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAV 1222

  Fly   279 AYVNLEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREGLMSQAENACRLAWKLGKQH 343
            .:..::|::||......|::            |.:.:||.::.|.|  ...:|...|:::.|...
  Rat  1223 LHSQMKKHSEALPLYERALK------------IYEDSLGRMHPRVG--ETLKNLAVLSYEEGNFE 1273

  Fly   344 QNPDAVEQAEYCLNEIKTTLNGEK 367
            :..:..::|.. :.|.:|:|.|.|
  Rat  1274 KAAELYKRAME-IKEAETSLLGGK 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ttc19NP_609934.3 TPR_12 235..302 CDD:290160 14/66 (21%)
TPR repeat 269..299 CDD:276809 8/29 (28%)
TPR_11 272..339 CDD:290150 14/66 (21%)
TPR repeat 304..338 CDD:276809 7/33 (21%)
Nphp3NP_001178811.1 Prefoldin 112..207 CDD:298833
OmpH <120..>202 CDD:281871
P-loop_NTPase 502..>556 CDD:304359
TPR_12 937..1012 CDD:290160
TPR_10 937..978 CDD:290111
TPR repeat 938..966 CDD:276809
TPR_12 976..1054 CDD:290160 7/32 (22%)
TPR repeat 976..1009 CDD:276809
TPR_10 979..1020 CDD:290111
TPR repeat 1022..1074 CDD:276809 12/52 (23%)
TPR_12 1085..1162 CDD:290160 18/82 (22%)
TPR_10 1088..1128 CDD:290111 9/45 (20%)
TPR repeat 1088..1116 CDD:276809 6/33 (18%)
TPR_12 1126..1204 CDD:290160 21/129 (16%)
TPR repeat 1129..1164 CDD:276809 9/34 (26%)
TPR_10 1130..1169 CDD:290111 11/42 (26%)
TPR_12 1168..1246 CDD:290160 21/141 (15%)
TPR repeat 1172..1200 CDD:276809 9/51 (18%)
TPR_10 1177..1211 CDD:290111 9/57 (16%)
TPR_12 1210..1288 CDD:290160 17/92 (18%)
TPR_10 1213..1254 CDD:290111 11/52 (21%)
TPR repeat 1213..1243 CDD:276809 8/41 (20%)
TPR repeat 1256..1284 CDD:276809 5/29 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1840
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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