DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ttc19 and Klc4

DIOPT Version :9

Sequence 1:NP_609934.3 Gene:Ttc19 / 35172 FlyBaseID:FBgn0032744 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_001009601.1 Gene:Klc4 / 316226 RGDID:1306555 Length:619 Species:Rattus norvegicus


Alignment Length:284 Identity:64/284 - (22%)
Similarity:118/284 - (41%) Gaps:46/284 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 IKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAMEREQFKKAEK 158
            :.|:...:..:.|:|  |.:|..:|:.||.:.:....:|  .:....:.:|.|..:|.::|:||.
  Rat   252 VATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGRDHPAVAATLNNLAVLYGKRGKYKEAEP 316

  Fly   159 I---FTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKM--P 218
            :   ..::.:::....|    |.:....:.:|.:.|.||..|...:.:    |:...:.|:.  |
  Rat   317 LCQRALEIREKVLGTDH----PDVAKQLNNLALLCQNQGKYEAVERYY----QRALAIYERQLGP 373

  Fly   219 DDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVNDASVTILNNISVAYVN 282
            |:.::..    |||......:|||||.||:.|:||..... :..:|:|:|....|.         
  Rat   374 DNPNVAR----TKNNLASCYLKQGKYSEAETLYKEILTRAHVQEFGSVDDDHKPIW--------- 425

  Fly   283 LEKYAEARETLLEAMELTKELKDATQEGILQA-------------NLGLVYLREGLMSQAENACR 334
              .:||.||.:..:.........|...|..:|             |||.:|.|:|.:..||....
  Rat   426 --MHAEEREEMSRSRSRESGTPYAEYGGWYKACRVSSPTVNTTLRNLGALYRRQGKLEAAETLEE 488

  Fly   335 LAWKLGKQHQNPDAVEQAEYCLNE 358
            .|.:..||..:|.:..:....|.|
  Rat   489 CALRSRKQGTDPISQTKVAELLGE 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ttc19NP_609934.3 TPR_12 235..302 CDD:290160 18/67 (27%)
TPR repeat 269..299 CDD:276809 5/29 (17%)
TPR_11 272..339 CDD:290150 17/79 (22%)
TPR repeat 304..338 CDD:276809 12/46 (26%)
Klc4NP_001009601.1 SMC_prok_B 33..>148 CDD:274008
TPR 1 55..88
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..200
TPR_12 210..285 CDD:315987 8/32 (25%)
TPR 2 211..244
TPR repeat 212..239 CDD:276809
TPR_12 251..327 CDD:315987 15/74 (20%)
TPR 3 253..286 8/32 (25%)
TPR repeat 253..281 CDD:276809 7/27 (26%)
TPR_12 294..369 CDD:315987 14/82 (17%)
TPR 4 295..328 6/32 (19%)
TPR repeat 295..323 CDD:276809 6/27 (22%)
TPR_12 335..409 CDD:315987 22/81 (27%)
TPR repeat 336..366 CDD:276809 6/33 (18%)
TPR 5 337..370 7/36 (19%)
TPR_12 378..496 CDD:315987 33/132 (25%)
TPR 6 379..412 13/36 (36%)
TPR repeat 379..406 CDD:276809 13/30 (43%)
TPR 7 464..497 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 571..619
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1840
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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