DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc19 and NPHP3

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_694972.3	Gene:	NPHP3 / 27031	HGNCID:	7907	Length:	1330	Species:	Homo sapiens

Alignment Length:	349	Identity:	72/349 - (20%)
Similarity:	133/349 - (38%)	Gaps:	89/349 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LAPL--KRSRYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTL-NLFGGADEK 89
            ||.|  |:::|.|...|       ....:::...|....|:..|.......|..| .|..|.|
Human  1033 LATLYQKQNKYEQAEHF-------RKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKD-- 1088

  Fly    90 EETPEEKLIKTIKR-SILCIQREQYDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAMERE 151
              ||:.  .:|:.. .:|...:...:.|:|.|..:|.|.:.:...|  ......:.:|.|..|::
Human  1089 --TPDN--ARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKK 1149

  Fly   152 QFKKAEKIF---TDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKL 213
            |:.|||:::   .|:.:|..|..|    |.:                        .:|::.||.|
Human  1150 QYDKAEELYERALDIRRRALAPDH----PSL------------------------AYTVKHLAIL 1186

  Fly   214 LEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISV 278
            .:||                        ||..:|..|::.|.:.....:|..:.:..|.|.|::|
Human  1187 YKKM------------------------GKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAV 1227

  Fly   279 AYVNLEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREGLMSQAENACRLAWKLGKQH 343
            .|..::|:.||......|::            |.:.:||.::.|.|  ...:|...|:::.|...
Human  1228 LYSQMKKHVEALPLYERALK------------IYEDSLGRMHPRVG--ETLKNLAVLSYEGGDFE 1278

  Fly   344 QNPDAVEQAEYCLNEIKTTLNGEK 367
            :..:..::|.. :.|.:|:|.|.|
Human  1279 KAAELYKRAME-IKEAETSLLGGK 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	15/66 (23%)
		TPR repeat	269..299	CDD:276809	9/29 (31%)
		TPR_11	272..339	CDD:290150	15/66 (23%)
		TPR repeat	304..338	CDD:276809	7/33 (21%)
NPHP3	NP_694972.3	Kinesin-relat_1	80..149	CDD:289481
		Uso1_p115_C	117..203	CDD:282695
		OmpH	<124..>206	CDD:281871
		TPR 1	471..504
		TPR 2	885..918
		TPR 3	920..942
		TPR_12	942..1017	CDD:290160
		TPR_10	942..983	CDD:290111
		TPR 4	943..976
		TPR repeat	943..971	CDD:276809
		TPR_12	981..1059	CDD:290160	7/32 (22%)
		TPR_10	984..1025	CDD:290111
		TPR 5	985..1018
		TPR repeat	985..1013	CDD:276809
		TPR repeat	1027..1079	CDD:276809	11/52 (21%)
		TPR 6	1027..1060		7/33 (21%)
		TPR_12	1090..1167	CDD:290160	17/78 (22%)
		TPR_10	1093..1133	CDD:290111	8/39 (21%)
		TPR 7	1093..1126		7/32 (22%)
		TPR repeat	1093..1121	CDD:276809	5/27 (19%)
		TPR_12	1131..1209	CDD:290160	23/129 (18%)
		TPR_10	1135..1174	CDD:290111	11/42 (26%)
		TPR 8	1135..1168		8/32 (25%)
		TPR repeat	1135..1163	CDD:276809	7/27 (26%)
		TPR_12	1173..1251	CDD:290160	24/141 (17%)
		TPR repeat	1173..1206	CDD:276809	13/84 (15%)
		TPR 9	1177..1210		11/56 (20%)
		TPR_10	1182..1216	CDD:290111	11/57 (19%)
		TPR_12	1215..1293	CDD:290160	18/92 (20%)
		TPR_10	1218..1259	CDD:290111	12/52 (23%)
		TPR 10	1219..1252		10/44 (23%)
		TPR repeat	1219..1247	CDD:276809	9/27 (33%)
		TPR 11	1261..1294		6/35 (17%)
		TPR repeat	1261..1289	CDD:276809	5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1330		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810