DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and Klc3

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_030098292.1	Gene:	Klc3 / 232943	MGIID:	1277971	Length:	574	Species:	Mus musculus

Alignment Length:	391	Identity:	83/391 - (21%)
Similarity:	144/391 - (36%)	Gaps:	119/391 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NAAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPEEKLIKT--IKRSILCIQREQ 112
            :.|...|..|||   ||:                 |...:...|||.:.:|  :.:.:..::.|.
Mouse     2 HGAAMSVQVAAP---GST-----------------GLGPERLNPEELVRQTRQVVQGLEALRAEH 46

  Fly   113 YDKAEQMLHLALRMA--------QDIQSKDGIT---------------YVFDLMANLAMEREQFK 154
            :..|.   |||..:|        :.::.|..:.               .:..|.|::::     .
Mouse    47 HSLAG---HLAEALAGPGPVAGVELLEEKQQVVNHSLEAIELGLGEAQVLLALSAHVSV-----L 103

  Fly   155 KAEKIFTDVMKRLFAEGHT------EESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQ---- 209
            :|||.......|..|:.:|      ||:.:.|..|.:.  ::||:.  |||...|...|:|
Mouse   104 EAEKQRLRAQARRLAQENTWLREELEETQRRLRASEEA--VAQLEE--EKSHLQFLGQLRQYDPP 164

  Fly   210 --------------LAKLLEKMPDDKD--------------------ILELYGLTKNWFGQLLMK 240
                          ||.|.....::|.                    :..|:.|...:.|
Mouse   165 EESQRPESPPRRDSLASLFPSEEEEKKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAG----- 224

  Fly   241 QGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYAEARETLLEAMELTKELKD 305
            ||:|..|..|.::|.:.|....|..:....|:||.:::.|.:..||.||.|.|.:|:::.::...
Mouse   225 QGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATELLHDALQIREQTLG 289

  Fly   306 ATQEGILQA--NLGLVYLREGLMSQAENACRLAWK-----LGKQHQNPDAVEQ----AEYCLNEI 359
            .....:...  ||.::|.:.|...:||..|:.|.:     ||..|  ||..:|    |..|.|:.
Mouse   290 PEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADH--PDVAKQLNNLALLCQNQG 352

  Fly   360 K 360
            |
Mouse   353 K 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	20/66 (30%)
		TPR repeat	269..299	CDD:276809	11/29 (38%)
		TPR_11	272..339	CDD:290150	18/73 (25%)
		TPR repeat	304..338	CDD:276809	8/35 (23%)
Klc3	XP_030098292.1	SMC_prok_B	26..>153	CDD:274008	27/138 (20%)
		TPR_12	211..286	CDD:315987	22/79 (28%)
		TPR repeat	213..240	CDD:276809	9/31 (29%)
		TPR_12	252..328	CDD:315987	19/75 (25%)
		TPR repeat	254..282	CDD:276809	11/27 (41%)
		TPR_12	295..370	CDD:315987	18/61 (30%)
		TPR repeat	296..324	CDD:276809	8/27 (30%)
		TPR_12	336..407	CDD:315987	6/18 (33%)
		TPR repeat	337..367	CDD:276809	5/17 (29%)
		TPR repeat	380..408	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810