DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and Klc1

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_006240683.1	Gene:	Klc1 / 171041	RGDID:	621411	Length:	615	Species:	Rattus norvegicus

Alignment Length:	309	Identity:	69/309 - (22%)
Similarity:	127/309 - (41%)	Gaps:	59/309 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EKEETPEEKLIKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAM 148
            ||....:...:.|:...:..:.|:|  |..|..:|:.||.:.:....:|  .:....:.:|.|..
  Rat   244 EKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYG 308

  Fly   149 EREQFKKAE---KIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQL 210
            :|.::|:||   |...::.:::..:.|    |.:....:.:|.:.|.||..|:    ..:..|:.
  Rat   309 KRGKYKEAEPLCKRALEIREKVLGKDH----PDVAKQLNNLALLCQNQGKYEE----VEYYYQRA 365

  Fly   211 AKLLEKM--PDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVNDASVTI 272
            .::.:..  |||.::.:    |||......:||||:.:|:.|:||..... ...:|:|:|.:..|
  Rat   366 LEIYQTKLGPDDPNVAK----TKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPI 426

  Fly   273 LNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEG-----------------ILQANLGLVY 320
            .           .:||.||      |...:.||.:..|                 ....|||.:|
  Rat   427 W-----------MHAEERE------ECKGKQKDGSSFGEYGGWYKACKVDSPTVTTTLKNLGALY 474

  Fly   321 LREGLMSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIKTTLNGEKRQ 369
            .|:|....||.....|.:..||..:....::....||:.:   |.|||:
  Rat   475 RRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAEVLNDPE---NVEKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	17/67 (25%)
		TPR repeat	269..299	CDD:276809	5/29 (17%)
		TPR_11	272..339	CDD:290150	18/83 (22%)
		TPR repeat	304..338	CDD:276809	12/50 (24%)
Klc1	XP_006240683.1	TPR_12	210..287	CDD:290160	10/42 (24%)
		TPR_10	213..253	CDD:290111	2/8 (25%)
		TPR repeat	214..241	CDD:276809
		TPR_12	251..329	CDD:290160	16/77 (21%)
		TPR_10	254..294	CDD:290111	9/39 (23%)
		TPR repeat	255..283	CDD:276809	7/27 (26%)
		TPR_12	293..370	CDD:290160	15/84 (18%)
		TPR_10	296..337	CDD:290111	8/44 (18%)
		TPR repeat	297..325	CDD:276809	7/27 (26%)
		TPR_12	335..413	CDD:290160	22/89 (25%)
		TPR_10	338..379	CDD:290111	9/44 (20%)
		TPR repeat	338..368	CDD:276809	6/33 (18%)
		TPR_10	380..417	CDD:290111	11/40 (28%)
		TPR repeat	381..408	CDD:276809	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810