Protein Alignment Ttc19 and Klc2

DIOPT Version :10

• Sequence 1: NP_609934.3
• Gene: Ttc19 / 35172
• FlyBaseID: FBgn0032744
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_001356290.1
• Gene: Klc2 / 16594
• MGIID: 107953
• Length: 636
• Species: Mus musculus
• Alignment Length: 284
• Identity: 66/284 - (23%)
• Similarity: 123/284 - (43%)
• Gaps: 35/284 - (12%)

  Fly    88 EKEETPEEKLIKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAM 148
            ||....:...:.|:...:..:.|:|  |..|..:|:.||.:.:....||  .:....:.:|.|..
Mouse   229 EKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYG 293

  Fly   149 EREQFKKAE---KIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQL 210
            :|.::|:||   |...::.:::..:.|    |.:....|.:|.:.|.||..|:....:...|:..
Mouse   294 KRGKYKEAEPLCKRALEIREKVLGKFH----PDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIY 354

  Fly   211 AKLLEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVN---DASV- 270
            |..|.  |||.::.:    |||......:|||||.:|:.|:||..... ...:|:||   :.||
Mouse   355 ATRLG--PDDPNVAK----TKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNARLERSVW 413

  Fly   271 ------TILNNISVAYVNLEKYAEARETLLEAM------ELTKELK-DATQEGILQANLGLVYLR 322
                  ::|......:::.|:..|:::...::.      ...|..| |:........:||.:|.|
Mouse   414 QAGDSPSLLGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRR 478

  Fly   323 EGLMSQAENACRLAWKLGKQHQNP 346
            :|.:..|......|.:..||..:|
Mouse   479 QGKLEAAHTLEDCASRSRKQGLDP 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	LapB	108..>350	CDD:442196	63/264 (24%)
		TPR repeat	269..299	CDD:276809	5/42 (12%)
		TPR repeat	304..338	CDD:276809	9/34 (26%)
Klc2	NP_001356290.1	Crescentin	26..>132	CDD:437057
		TPR	195..437	CDD:440225	52/217 (24%)
		TPR repeat	199..226	CDD:276809
		TPR repeat	240..268	CDD:276809	7/27 (26%)
		TPR repeat	282..310	CDD:276809	7/27 (26%)
		TPR repeat	323..353	CDD:276809	7/29 (24%)
		TPR repeat	366..393	CDD:276809	12/30 (40%)