DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and Klc2

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001356290.1	Gene:	Klc2 / 16594	MGIID:	107953	Length:	636	Species:	Mus musculus

Alignment Length:	284	Identity:	66/284 - (23%)
Similarity:	123/284 - (43%)	Gaps:	35/284 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EKEETPEEKLIKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAM 148
            ||....:...:.|:...:..:.|:|  |..|..:|:.||.:.:....||  .:....:.:|.|..
Mouse   229 EKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYG 293

  Fly   149 EREQFKKAE---KIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQL 210
            :|.::|:||   |...::.:::..:.|    |.:....|.:|.:.|.||..|:....:...|:..
Mouse   294 KRGKYKEAEPLCKRALEIREKVLGKFH----PDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIY 354

  Fly   211 AKLLEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVN---DASV- 270
            |..|.  |||.::.:    |||......:|||||.:|:.|:||..... ...:|:||   :.||
Mouse   355 ATRLG--PDDPNVAK----TKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNARLERSVW 413

  Fly   271 ------TILNNISVAYVNLEKYAEARETLLEAM------ELTKELK-DATQEGILQANLGLVYLR 322
                  ::|......:::.|:..|:::...::.      ...|..| |:........:||.:|.|
Mouse   414 QAGDSPSLLGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRR 478

  Fly   323 EGLMSQAENACRLAWKLGKQHQNP 346
            :|.:..|......|.:..||..:|
Mouse   479 QGKLEAAHTLEDCASRSRKQGLDP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	17/83 (20%)
		TPR repeat	269..299	CDD:276809	5/42 (12%)
		TPR_11	272..339	CDD:290150	13/73 (18%)
		TPR repeat	304..338	CDD:276809	9/34 (26%)
Klc2	NP_001356290.1	SMC_prok_B	<9..>139	CDD:274008
		TPR_12	197..272	CDD:315987	10/42 (24%)
		TPR repeat	199..226	CDD:276809
		TPR_12	238..314	CDD:315987	17/75 (23%)
		TPR repeat	240..268	CDD:276809	7/27 (26%)
		TPR_12	281..354	CDD:315987	16/76 (21%)
		TPR repeat	282..310	CDD:276809	7/27 (26%)
		TPR_12	322..396	CDD:315987	24/79 (30%)
		TPR repeat	323..353	CDD:276809	7/29 (24%)
		TPR repeat	366..393	CDD:276809	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810