DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and Klc1

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_036013090.1	Gene:	Klc1 / 16593	MGIID:	107978	Length:	637	Species:	Mus musculus

Alignment Length:	311	Identity:	70/311 - (22%)
Similarity:	128/311 - (41%)	Gaps:	63/311 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EKEETPEEKLIKTIKRSILCIQREQ--YDKAEQMLHLALRMAQDIQSKD--GITYVFDLMANLAM 148
            ||....:...:.|:...:..:.|:|  |..|..:|:.||.:.:....:|  .:....:.:|.|..
Mouse   244 EKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYG 308

  Fly   149 EREQFKKAE---KIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQG---DLEKSFQGFTWTL 207
            :|.::|:||   |...::.:::..:.|    |.:....:.:|.:.|.||   ::|..:|
Mouse   309 KRGKYKEAEPLCKRALEIREKVLGKDH----PDVAKQLNNLALLCQNQGKYEEVEYYYQ------ 363

  Fly   208 QQLAKLLEKM-PDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTL-INVYGAVNDASV 270
            :.|.....|: |||.::.:    |||......:||||:.:|:.|:||..... ...:|:|:|.:.
Mouse   364 RALGIYQTKLGPDDPNVAK----TKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENK 424

  Fly   271 TILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEG-----------------ILQANLGL 318
            .|.           .:||.||      |...:.||.:..|                 ....|||.
Mouse   425 PIW-----------MHAEERE------ECKGKQKDGSAFGEYGGWYKACKVDSPTVTTTLKNLGA 472

  Fly   319 VYLREGLMSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIKTTLNGEKRQ 369
            :|.|:|....||.....|.:..||..:....::....||:.::.   |||:
Mouse   473 LYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPESM---EKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	17/67 (25%)
		TPR repeat	269..299	CDD:276809	5/29 (17%)
		TPR_11	272..339	CDD:290150	18/83 (22%)
		TPR repeat	304..338	CDD:276809	12/50 (24%)
Klc1	XP_036013090.1	SMC_prok_B	35..>149	CDD:274008
		TPR_12	212..287	CDD:315987	10/42 (24%)
		TPR repeat	214..241	CDD:276809
		TPR_12	253..329	CDD:315987	16/75 (21%)
		TPR repeat	255..283	CDD:276809	7/27 (26%)
		TPR_12	296..370	CDD:315987	16/83 (19%)
		TPR repeat	297..325	CDD:276809	7/27 (26%)
		TPR_12	337..411	CDD:315987	22/83 (27%)
		TPR repeat	338..368	CDD:276809	7/35 (20%)
		TPR repeat	381..408	CDD:276809	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810