DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and KLC3

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_024307137.1	Gene:	KLC3 / 147700	HGNCID:	20717	Length:	703	Species:	Homo sapiens

Alignment Length:	413	Identity:	89/413 - (21%)
Similarity:	153/413 - (37%)	Gaps:	108/413 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SEFGCR--------PLCSNAAGYEVSWAAPPASGSS-----GGMFWAFSAAFTLNL----FGGAD 87
            |..|||        |....|:|.. |...|.|.|..     ||..|. .||.::.:    ..|..
Human     3 SRRGCRLHTPRLTLPAEEGASGPR-SHGQPGALGQGIQGPWGGEGWP-GAAMSVQVAAPGSAGLG 65

  Fly    88 EKEETPEEKLIKT--IKRSILCIQREQYDKAEQMLHLA-----------LRMAQDIQ-----SKD 134
            .:..:|||.:.:|  :.:.:..::.|.:..|.   |||           |.|.::.|     |.:
Human    66 PERLSPEELVRQTRQVVQGLEALRAEHHGLAG---HLAEALAGQGPAAGLEMLEEKQQVVSHSLE 127

  Fly   135 GI-------TYVFDLMANL-AMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQ 191
            .|       ..:..|.|:: |:|.|:.:...:......:.::.....||:.:.|..|.:    |.
Human   128 AIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE----SV 188

  Fly   192 LQGDLEKSFQGFTWTLQQ------------------LAKLLEKMPDDKD---------------- 222
            .|.:.||....|...|:|                  ||.|.....:::.
Human   189 AQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYE 253

  Fly   223 ----ILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNL 283
                :..|:.|...:.|     ||:|..|..|.::|.:.|....|..:....|:||.:::.|.:.
Human   254 IPARLRTLHNLVIQYAG-----QGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQ 313

  Fly   284 EKYAEARETLLEAMELTKELKDATQEGILQA--NLGLVYLREGLMSQAENACRLAWK-----LGK 341
            .||.||.:.|.:|:::.::........:...  ||.::|.:.|...:||..|:.|.:     ||.
Human   314 NKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGA 378

  Fly   342 QHQNPDAVEQ----AEYCLNEIK 360
            .|  ||..:|    |..|.|:.|
Human   379 DH--PDVAKQLNNLALLCQNQGK 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	19/66 (29%)
		TPR repeat	269..299	CDD:276809	10/29 (34%)
		TPR_11	272..339	CDD:290150	17/73 (23%)
		TPR repeat	304..338	CDD:276809	8/35 (23%)
KLC3	XP_024307137.1	TPR_12	257..332	CDD:315987	21/79 (27%)
		TPR repeat	259..286	CDD:276809	9/31 (29%)
		TPR_12	298..374	CDD:315987	18/75 (24%)
		TPR repeat	300..328	CDD:276809	10/27 (37%)
		TPR_12	341..416	CDD:315987	18/61 (30%)
		TPR repeat	342..370	CDD:276809	8/27 (30%)
		TPR_12	382..453	CDD:315987	6/18 (33%)
		TPR repeat	383..413	CDD:276809	5/17 (29%)
		TPR repeat	426..453	CDD:276809
		SMC_N	72..>199	CDD:330553	26/133 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810