DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and AgaP_AGAP010258

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_319447.2	Gene:	AgaP_AGAP010258 / 1279680	VectorBaseID:	AGAP010258	Length:	509	Species:	Anopheles gambiae

Alignment Length:	344	Identity:	72/344 - (20%)
Similarity:	124/344 - (36%)	Gaps:	105/344 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LNLFGGADEKEETPEEKLIKTIKRSILCIQREQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMA 144
            :.|.....|..:|..:|: :.:|:::            :.:.|.|..||      .|..:|..:.
Mosquito    28 VTLMNNLAEGSKTDPDKM-EIVKKNM------------ENIELGLSEAQ------VIVMLFAHLQ 73

  Fly   145 NLAMEREQFKKAEKIFTDVMKRLFAE----------------------GHTEESPKILHISSKIA 187
            |:..|:      :|:.|.| |||..|                      ...||..|.|...:.:.
Mosquito    74 NIEAEK------QKLRTQV-KRLCQENVWLRDELAITQQKLQASEQSVAQLEEEKKHLEFMASVK 131

  Fly   188 HMSQLQ---GDLEKSFQGFTWTLQQLAKLLEKMPDDK---------------------------D 222
            ...::|   .:||||         :...::|..|:|:                           .
Mosquito   132 KYDEIQENEDNLEKS---------RTDPVVELFPEDEAEERNNMSPTPPNQFANHANAGYEIPAR 187

  Fly   223 ILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYA 287
            :..|:.|...:     ..||:|..|..|.|:|.:.|....|..:....|:||.:::.|.:..||.
Mosquito   188 LRTLHNLVIQY-----ASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYK 247

  Fly   288 EARETLLEAMELTKELKDATQEGILQA--NLGLVYLREGLMSQAENACRLAWK-----LGKQHQN 345
            ||...|.:|:.:.::........:...  ||.::|.:.|....||..|:.|.:     |||.|
Mosquito   248 EAANLLNDALTIREKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIRENVLGKSH-- 310

  Fly   346 PDAVEQ----AEYCLNEIK 360
            ||..:|    |..|.|:.|
Mosquito   311 PDVAKQLNNLALLCQNQAK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	19/66 (29%)
		TPR repeat	269..299	CDD:276809	10/29 (34%)
		TPR_11	272..339	CDD:290150	17/73 (23%)
		TPR repeat	304..338	CDD:276809	8/35 (23%)
AgaP_AGAP010258	XP_319447.2	NUDE_C	66..>111	CDD:282704	10/51 (20%)
		TPR_12	185..262	CDD:290160	21/81 (26%)
		TPR_10	188..228	CDD:290111	11/44 (25%)
		TPR repeat	189..216	CDD:276809	9/31 (29%)
		TPR_12	226..304	CDD:290160	18/77 (23%)
		TPR_10	229..269	CDD:290111	10/39 (26%)
		TPR repeat	230..258	CDD:276809	10/27 (37%)
		TPR_12	268..345	CDD:290160	19/64 (30%)
		TPR_10	271..312	CDD:290111	12/42 (29%)
		TPR repeat	272..300	CDD:276809	8/27 (30%)
		TPR_12	310..388	CDD:290160	8/22 (36%)
		TPR_10	313..354	CDD:290111	5/17 (29%)
		TPR repeat	313..343	CDD:276809	5/17 (29%)
		TPR_12	352..471	CDD:290160
		TPR_10	355..393	CDD:290111
		TPR repeat	356..383	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810